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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: CHD2

Summary for CHD2

Gene information	Gene symbol	CHD2
	Ensembl ID	ENSG00000173575
	Entrez ID	1106
	Gene name	chromodomain helicase DNA binding protein 2
	Synonyms	DKFZp547I1315\|DKFZp686E01200\|DKFZp781D1727\|FLJ38614
	Gene type	protein_coding
	UniProtAcc	O14647

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Dataset with differentially expressed gene: CHD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.325197	3.07e-21
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.357752	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.311292	6.52e-40
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.340808	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.271965	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.375695	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.340215	1.59e-24
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.437605	1.28e-22
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-1.09181	2.08e-02
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.45345	6.88e-26
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.336335	3.93e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.392043	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.322503	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.401598	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.294468	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.276282	2.28e-06

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Expression of CHD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHD2	hsa-miR-4713-5p	96.7232	NM_001271
CHD2	hsa-miR-8065	96.6827	NM_001271
CHD2	hsa-miR-150-5p	96.221	NM_001271
CHD2	hsa-miR-4455	96.0227	NM_001042572
CHD2	hsa-miR-4668-5p	95.6736	NM_001271
CHD2	hsa-miR-200a-3p	95.209	NM_001271
CHD2	hsa-miR-141-3p	95.209	NM_001271
CHD2	hsa-miR-513b-5p	94.7952	NM_001271
CHD2	hsa-miR-4448	94.7824	NM_001271
CHD2	hsa-miR-6733-3p	94.7583	NM_001271
CHD2	hsa-miR-10401-5p	94.2038	NM_001271
CHD2	hsa-miR-4719	93.965	NM_001271
CHD2	hsa-miR-7703	93.4005	NM_001042572
CHD2	hsa-miR-516b-3p	93.3531	NM_001271
CHD2	hsa-miR-516a-3p	93.3531	NM_001271
CHD2	hsa-miR-7162-5p	93.3531	NM_001271
CHD2	hsa-miR-15b-5p	93.1748	NM_001271
CHD2	hsa-miR-107	92.7593	NM_001271
CHD2	hsa-miR-103a-3p	92.7593	NM_001271
CHD2	hsa-miR-224-5p	92.6108	NM_001271
CHD2	hsa-miR-370-3p	92.5268	NM_001271
CHD2	hsa-miR-195-5p	92.3109	NM_001271
CHD2	hsa-miR-6838-5p	92.3109	NM_001271
CHD2	hsa-miR-16-5p	92.3109	NM_001271
CHD2	hsa-miR-15a-5p	92.3109	NM_001271
CHD2	hsa-miR-424-5p	91.7753	NM_001271
CHD2	hsa-miR-146a-3p	91.5092	NM_001271
CHD2	hsa-miR-657	91.0394	NM_001271
CHD2	hsa-miR-497-5p	90.7174	NM_001271
CHD2	hsa-miR-6893-3p	90.628	NM_001271
CHD2	hsa-miR-6756-3p	90.0552	NM_001271
CHD2	hsa-miR-3127-3p	90.0552	NM_001271
CHD2	hsa-miR-6753-3p	89.414	NM_001271
CHD2	hsa-miR-7107-3p	89.414	NM_001271
CHD2	hsa-miR-183-5p	87.6417	NM_001271
CHD2	hsa-miR-617	87.6396	NM_001271
CHD2	hsa-miR-381-3p	86.5585	NM_001271
CHD2	hsa-miR-300	86.5585	NM_001271
CHD2	hsa-miR-3619-5p	85.8387	NM_001271
CHD2	hsa-miR-4733-3p	85.7926	NM_001271
CHD2	hsa-miR-19b-3p	85.6723	NM_001271
CHD2	hsa-miR-19a-3p	85.6723	NM_001271
CHD2	hsa-miR-3652	85.2972	NM_001271
CHD2	hsa-miR-4430	85.2972	NM_001271
CHD2	hsa-miR-5693	84.9578	NM_001271
CHD2	hsa-miR-2355-5p	84.8139	NM_001271
CHD2	hsa-miR-6740-5p	83.6759	NM_001271
CHD2	hsa-miR-452-5p	83.3287	NM_001271
CHD2	hsa-miR-892c-3p	83.3287	NM_001271
CHD2	hsa-miR-4676-3p	83.3287	NM_001271

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Motifs and transcription factors (TFs) regulating CHD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHD2	metacluster_175.1	ZNF283 (directAnnotation).
CHD2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
CHD2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
CHD2	transfac_pro__M01199	TRIM28 (directAnnotation).
CHD2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
CHD2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
CHD2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
CHD2	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
CHD2	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CHD2	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CHD2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CHD2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CHD2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CHD2	transfac_pro__M00430	E2F1 (directAnnotation).
CHD2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CHD2	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
CHD2	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
CHD2	hdpi__HIP2	UBE2K (directAnnotation).
CHD2	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CHD2	hdpi__TIMELESS	TIMELESS (directAnnotation).
CHD2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CHD2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CHD2	metacluster_191.5	SPDEF (inferredBy_Orthology).
CHD2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CHD2	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
CHD2	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
CHD2	hdpi__RARA	RARA (directAnnotation).
CHD2	hdpi__ELF2	ELF2 (directAnnotation).
CHD2	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
CHD2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
CHD2	jaspar__MA1583.1	ZFP57 (directAnnotation).
CHD2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
CHD2	jaspar__MA1721.1	ZNF93 (directAnnotation).
CHD2	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
CHD2	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CHD2	metacluster_141.4	GLIS2 (directAnnotation).
CHD2	hdpi__TP73	TP73 (directAnnotation).
CHD2	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
CHD2	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
CHD2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
CHD2	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
CHD2	transfac_pro__M07483	CXXC1 (directAnnotation).
CHD2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
CHD2	transfac_pro__M01861	ATF1 (directAnnotation).
CHD2	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
CHD2	hdpi__NRL	NRL (directAnnotation).
CHD2	hdpi__FEZF2	FEZF2 (directAnnotation).
CHD2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
CHD2	metacluster_155.11	SPZ1 (directAnnotation).
CHD2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
CHD2	metacluster_172.6	up	Malignant cells	GSE138267	NA
CHD2	metacluster_172.6	up	B cells	GSE169246_PacBlood	pre
CHD2	metacluster_172.6	up	CD4+ T cells	GSE169246_PacBlood	pre
CHD2	metacluster_33.8	up	Malignant cells	GSE186960	NA

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."