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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: CHD1

Summary for CHD1

Gene information	Gene symbol	CHD1
	Ensembl ID	ENSG00000153922
	Entrez ID	1105
	Gene name	chromodomain helicase DNA binding protein 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: CHD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.293624	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.293307	2.04e-09
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.286515	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.269819	2.85e-13
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.329767	3.79e-11
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD4+ T cells	0.395839	7.63e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.532292	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.543275	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.254892	2.27e-24
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.508219	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.320649	8.58e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.777605	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.589379	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.286519	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.326999	0.00e+00

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Expression of CHD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to CHD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating CHD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
CHD1	hsa-miR-548az-5p	99.6675	NM_001270
CHD1	hsa-miR-548t-5p	99.6675	NM_001270
CHD1	hsa-miR-570-3p	99.1718	NM_001270
CHD1	hsa-miR-12136	98.571	NM_001270
CHD1	hsa-miR-3163	98.4635	NM_001270
CHD1	hsa-miR-3910	98.25	NM_001270
CHD1	hsa-miR-30d-5p	97.9302	NM_001270
CHD1	hsa-miR-30c-5p	97.9302	NM_001270
CHD1	hsa-miR-30a-5p	97.9302	NM_001270
CHD1	hsa-miR-30b-5p	97.9302	NM_001270
CHD1	hsa-miR-30e-5p	97.9302	NM_001270
CHD1	hsa-miR-135a-5p	96.5844	NM_001270
CHD1	hsa-miR-135b-5p	96.5844	NM_001270
CHD1	hsa-miR-212-3p	96.3816	NM_001270
CHD1	hsa-miR-132-3p	96.3816	NM_001270
CHD1	hsa-miR-889-5p	96.0291	NM_001270
CHD1	hsa-miR-4693-5p	94.8904	NM_001270
CHD1	hsa-miR-548n	94.602	NM_001270
CHD1	hsa-miR-1297	94.1562	NM_001270
CHD1	hsa-miR-500a-5p	94.0834	NM_001270
CHD1	hsa-miR-4803	94.0015	NM_001270
CHD1	hsa-miR-548an	93.8247	NM_001270
CHD1	hsa-miR-3944-5p	93.729	NM_001270
CHD1	hsa-miR-194-5p	93.3918	NM_001270
CHD1	hsa-miR-26b-5p	92.6857	NM_001270
CHD1	hsa-miR-26a-5p	92.6857	NM_001270
CHD1	hsa-miR-498-5p	92.6002	NM_001270
CHD1	hsa-miR-338-5p	92.5975	NM_001270
CHD1	hsa-miR-4465	91.7259	NM_001270
CHD1	hsa-miR-571	91.6508	NM_001270
CHD1	hsa-miR-6499-3p	91.3938	NM_001270
CHD1	hsa-miR-6083	90.4224	NM_001270
CHD1	hsa-miR-4302	89.8126	NM_001270
CHD1	hsa-miR-4324	89.7062	NM_001270
CHD1	hsa-miR-6074	89.5749	NM_001270
CHD1	hsa-miR-651-3p	88.4401	NM_001270
CHD1	hsa-miR-146b-3p	87.8386	NM_001270
CHD1	hsa-miR-585-5p	87.3951	NM_001270
CHD1	hsa-miR-4262	87.2844	NM_001270
CHD1	hsa-miR-892a	86.942	NM_001270
CHD1	hsa-miR-4293	86.7665	NM_001270
CHD1	hsa-miR-4425	86.2794	NM_001270
CHD1	hsa-miR-339-5p	85.2918	NM_001270
CHD1	hsa-miR-6801-5p	84.8338	NM_001270
CHD1	hsa-miR-10393-3p	84.8338	NM_001270
CHD1	hsa-miR-198	84.7053	NM_001270
CHD1	hsa-miR-153-5p	84.3486	NM_001270
CHD1	hsa-miR-3978	84.1508	NM_001270
CHD1	hsa-miR-3177-5p	83.9564	NM_001270
CHD1	hsa-miR-9902	83.6477	NM_001270

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Motifs and transcription factors (TFs) regulating CHD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
CHD1	transfac_public__M00144	PAX5 (directAnnotation).
CHD1	cisbp__M01864	EGR1 (inferredBy_Orthology).
CHD1	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
CHD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
CHD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
CHD1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
CHD1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
CHD1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
CHD1	cisbp__M00788	ZFY (inferredBy_Orthology).
CHD1	transfac_pro__M00430	E2F1 (directAnnotation).
CHD1	transfac_pro__M04893	TAF1 (directAnnotation).
CHD1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
CHD1	transfac_pro__M01199	TRIM28 (directAnnotation).
CHD1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
CHD1	hdpi__HIP2	UBE2K (directAnnotation).
CHD1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
CHD1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
CHD1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
CHD1	transfac_pro__M00938	E2F1 (directAnnotation).
CHD1	hdpi__RARA	RARA (directAnnotation).
CHD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
CHD1	jaspar__MA1583.1	ZFP57 (directAnnotation).
CHD1	cisbp__M00968	MTF2 (directAnnotation).
CHD1	jaspar__MA1721.1	ZNF93 (directAnnotation).
CHD1	transfac_pro__M04916	TAF1 (directAnnotation).
CHD1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
CHD1	transfac_pro__M07310	SP5 (directAnnotation).
CHD1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
CHD1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
CHD1	cisbp__M00249	WT1 (directAnnotation).
CHD1	hdpi__ZNF304	ZNF304 (directAnnotation).
CHD1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
CHD1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
CHD1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
CHD1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
CHD1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
CHD1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
CHD1	transfac_pro__M01253	CNOT3 (directAnnotation).
CHD1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
CHD1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
CHD1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
CHD1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
CHD1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
CHD1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
CHD1	transfac_pro__M04817	ZBTB33 (directAnnotation).
CHD1	transfac_pro__M12697	ZNF142 (directAnnotation).
CHD1	metacluster_175.1	ZNF283 (directAnnotation).
CHD1	tfdimers__MD00364	WT1 (directAnnotation).
CHD1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
CHD1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
CHD1	swissregulon__hs__CHD1	up	Malignant cells	GSE138267	NA
CHD1	swissregulon__hs__CHD1	up	CD4+ T cells	GSE169246_PacBlood	pre
CHD1	swissregulon__hs__CHD1	down	Malignant cells	GSE199333	post
CHD1	swissregulon__hs__CHD1	down	Malignant cells	GSE199333	pre

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."