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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ARL4C

Summary for ARL4C

Gene information	Gene symbol	ARL4C
	Ensembl ID	ENSG00000188042
	Entrez ID	10123
	Gene name	ADP ribosylation factor like GTPase 4C
	Synonyms	ARL7\|LAK
	Gene type	protein_coding
	UniProtAcc	P56559

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Dataset with differentially expressed gene: ARL4C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.525474	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.387052	2.06e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD8+ T cells	0.492235	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.269349	3.32e-16
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.541262	3.92e-20
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.40834	7.81e-25
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.846879	5.36e-13
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	-0.417139	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.71054	1.83e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.490173	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	NK cells	-0.26907	3.76e-36
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.365085	8.23e-28
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	NK cells	-0.450661	4.38e-07
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	0.305537	0.00e+00
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	post	cDCs	-0.583144	8.77e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-1.56032	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	0.296719	4.82e-04
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	NK cells	0.387438	7.98e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD4+ T cells	0.363575	5.44e-03
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.265565	1.09e-07
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD8+ T cells	-0.266175	3.14e-04
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.437818	1.60e-31
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.933788	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	1.18991	0.00e+00

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Expression of ARL4C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ARL4C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ARL4C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ARL4C	hsa-miR-3611	97.8623	NM_005737
ARL4C	hsa-miR-3919	97.6448	NM_005737
ARL4C	hsa-miR-508-3p	95.5727	NM_001282431
ARL4C	hsa-miR-1290	95.4608	NM_001282431
ARL4C	hsa-miR-568	94.4267	NM_001282431
ARL4C	hsa-miR-4524a-3p	93.774	NM_005737
ARL4C	hsa-miR-513a-5p	93.5831	NM_005737
ARL4C	hsa-miR-586	93.4202	NM_001282431
ARL4C	hsa-miR-4761-5p	92.9367	NM_005737
ARL4C	hsa-miR-4261	92.6163	NM_001282431
ARL4C	hsa-miR-520h	92.5493	NM_005737
ARL4C	hsa-miR-520g-3p	92.5493	NM_005737
ARL4C	hsa-miR-6770-5p	92.421	NM_001282431
ARL4C	hsa-miR-6843-3p	92.0443	NM_005737
ARL4C	hsa-miR-6848-3p	92.0443	NM_005737
ARL4C	hsa-miR-302e	91.7509	NM_005737
ARL4C	hsa-miR-27b-3p	91.1955	NM_005737
ARL4C	hsa-miR-27a-3p	91.1955	NM_005737
ARL4C	hsa-miR-9985	91.1955	NM_005737
ARL4C	hsa-miR-147b-5p	90.9137	NM_001282431
ARL4C	hsa-miR-520c-3p	89.2795	NM_005737
ARL4C	hsa-miR-520e-3p	89.2795	NM_005737
ARL4C	hsa-miR-520d-3p	89.2795	NM_005737
ARL4C	hsa-miR-520b-3p	89.2795	NM_005737
ARL4C	hsa-miR-372-3p	89.2795	NM_005737
ARL4C	hsa-miR-302c-3p	89.2795	NM_005737
ARL4C	hsa-miR-302b-3p	89.2795	NM_005737
ARL4C	hsa-miR-302d-3p	89.2795	NM_005737
ARL4C	hsa-miR-373-3p	89.2795	NM_005737
ARL4C	hsa-miR-302a-3p	89.2795	NM_005737
ARL4C	hsa-miR-520a-3p	89.2795	NM_005737
ARL4C	hsa-miR-6833-3p	88.5059	NM_001282431
ARL4C	hsa-miR-4768-5p	88.394	NM_001282431
ARL4C	hsa-miR-5692a	86.2601	NM_005737
ARL4C	hsa-miR-1284	85.2119	NM_005737
ARL4C	hsa-miR-340-5p	84.9007	NM_005737
ARL4C	hsa-miR-193b-5p	84.678	NM_005737
ARL4C	hsa-miR-152-5p	84.3009	NM_005737
ARL4C	hsa-miR-1291	84.2722	NM_001282431
ARL4C	hsa-miR-6741-5p	83.9005	NM_005737
ARL4C	hsa-miR-6775-3p	81.1003	NM_001282431
ARL4C	hsa-miR-6165	81.044	NM_005737
ARL4C	hsa-miR-548g-3p	80.5427	NM_005737
ARL4C	hsa-miR-4720-3p	80.1983	NM_001282431
ARL4C	hsa-miR-597-3p	80.1202	NM_005737

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Motifs and transcription factors (TFs) regulating ARL4C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ARL4C	transfac_pro__M05298	OVOL3 (directAnnotation).
ARL4C	transfac_pro__M06249	ZNF616 (directAnnotation).
ARL4C	tfdimers__MD00595	SREBF1; SREBF2; TBP (directAnnotation).
ARL4C	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
ARL4C	tfdimers__MD00527	IRF1; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; ZEB1 (directAnnotation).
ARL4C	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
ARL4C	taipale_cyt_meth__ZNF460_NAACGCCCCCCGN_eDBD_repr	ZNF460 (directAnnotation).
ARL4C	cisbp__M07938	E2F1 (directAnnotation).
ARL4C	transfac_pro__M06490	ZNF664 (directAnnotation).
ARL4C	transfac_pro__M07452	MEIS1 (directAnnotation).
ARL4C	taipale_tf_pairs__TEAD4_HES7_RCATTCCNNCRCGYGYN_CAP_repr	HES7; TEAD4 (directAnnotation).
ARL4C	transfac_public__M00237	AHR; ARNT (directAnnotation).
ARL4C	transfac_pro__M05329	KLF16 (inferredBy_Orthology).
ARL4C	dbtfbs__ZKSCAN8_representative_N1	ZKSCAN8 (directAnnotation).
ARL4C	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
ARL4C	transfac_pro__M06334	ZNF782 (directAnnotation).
ARL4C	metacluster_46.5	HLF; TEF (directAnnotation).
ARL4C	hocomoco__OTX1_HUMAN.H11MO.0.D	OTX1 (directAnnotation).
ARL4C	transfac_pro__M05668	ZNF154 (directAnnotation).
ARL4C	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
ARL4C	swissregulon__hs__ETV6	ETV6 (directAnnotation).
ARL4C	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
ARL4C	transfac_pro__M06305	ZNF583 (inferredBy_Orthology).
ARL4C	transfac_pro__M06092	ZNF28 (directAnnotation).
ARL4C	transfac_pro__M05869	ZNF454 (directAnnotation).
ARL4C	transfac_pro__M06723	ZNF492 (directAnnotation).
ARL4C	metacluster_111.4	ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
ARL4C	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
ARL4C	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
ARL4C	jaspar__MA1951.1	FOS (directAnnotation).
ARL4C	metacluster_148.1	ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6; ATF6B; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB3; CREB3; CREB5; CREB5; CREB5; CREM; CREM; FOS; FOS; FOSB; FOSB; FOSB; FOSL1; JDP2; JDP2; JUN; JUN; JUN; JUNB; JUND; MAF; MAF; MAFA; MAFA; MAFF; MAFF; MAFF; MAFF; MAFG; MAFG; ZBTB21 (directAnnotation). ATF1; ATF1; ATF1; ATF1; ATF6; ATF6; ATF6; ATF6; ATF6B; ATF6B; ATF6B; ATF6B; CREB1; CREB1; CREB3; CREB3; CREB3; CREB3; CREB3L1; CREB3L1; CREB3L1; CREB3L1; CREB3L2; CREB3L2; CREB3L2; CREB3L2; CREB3L3; CREB3L3; CREB3L3; CREB3L3; CREB3L4; CREB3L4; CREB3L4; CREB3L4; CREM; CREM; CREM; CREM; JDP2; JUN; JUNB; JUND; MAFB (inferredBy_Orthology).
ARL4C	transfac_pro__M04746	E2F1 (directAnnotation).
ARL4C	transfac_public__M00039	CREB1 (directAnnotation).
ARL4C	metacluster_165.10	HOXA1; HOXA2; HOXB1; HOXB1; PBX1; PBX1; PBX2; PBX2 (directAnnotation). HOXA1 (inferredBy_Orthology).
ARL4C	transfac_pro__M06017	ZNF586 (directAnnotation).
ARL4C	metacluster_174.4	PBX1; PBX1; PBX1; PBX1 (directAnnotation).
ARL4C	transfac_pro__M07399	NKX6-1 (directAnnotation).
ARL4C	tfdimers__MD00090	FOS; FOXG1; FOXO1 (directAnnotation).
ARL4C	cisbp__M02686	NKX2-5 (inferredBy_Orthology).
ARL4C	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ARL4C	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ARL4C	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ARL4C	hdpi__NRL	NRL (directAnnotation).
ARL4C	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
ARL4C	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
ARL4C	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
ARL4C	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ARL4C	metacluster_3.14	WT1; WT1 (directAnnotation).
ARL4C	transfac_pro__M01837	KLF11 (directAnnotation).
ARL4C	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."