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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ANKRD11

Summary for ANKRD11

Gene information	Gene symbol	ANKRD11
	Ensembl ID	ENSG00000167522
	Entrez ID	29123
	Gene name	ankyrin repeat domain containing 11
	Synonyms	ANCO-1\|ANCO1\|LZ16\|T13
	Gene type	protein_coding
	UniProtAcc	Q6UB99

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Dataset with differentially expressed gene: ANKRD11

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.626348	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.316031	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.286173	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.303784	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.255109	8.12e-05
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.337542	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.442482	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.452323	1.40e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.441779	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.263529	5.38e-08
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.391996	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.32487	7.18e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.295589	4.59e-34
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.279888	1.68e-17
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.572964	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.40454	0.00e+00

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Expression of ANKRD11 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ANKRD11

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ANKRD11

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ANKRD11	hsa-miR-143-5p	98.2566	NM_001256182
ANKRD11	hsa-miR-101-3p	97.8553	NM_001256182
ANKRD11	hsa-miR-760	97.7087	NM_001256182
ANKRD11	hsa-miR-8057	94.9616	NM_001256182
ANKRD11	hsa-miR-365a-3p	94.2438	NM_001256182
ANKRD11	hsa-miR-365b-3p	94.2438	NM_001256182
ANKRD11	hsa-miR-4789-3p	92.56	NM_001256182
ANKRD11	hsa-miR-383-5p	92.518	NM_001256182
ANKRD11	hsa-miR-1468-3p	92.419	NM_001256182
ANKRD11	hsa-miR-548ar-3p	91.2132	NM_001256182
ANKRD11	hsa-miR-548aw	90.9284	NM_001256182
ANKRD11	hsa-miR-466	89.5286	NM_001256182
ANKRD11	hsa-miR-4684-3p	89.2456	NM_001256182
ANKRD11	hsa-miR-142-3p	89.0852	NM_001256182
ANKRD11	hsa-miR-548a-3p	88.7199	NM_001256182
ANKRD11	hsa-miR-548e-3p	88.7199	NM_001256182
ANKRD11	hsa-miR-548az-3p	88.7199	NM_001256182
ANKRD11	hsa-miR-548bc	88.7199	NM_001256182
ANKRD11	hsa-miR-548f-3p	88.7199	NM_001256182
ANKRD11	hsa-miR-548av-5p	87.0599	NM_001256182
ANKRD11	hsa-miR-8054	87.0599	NM_001256182
ANKRD11	hsa-miR-548k	87.0599	NM_001256182
ANKRD11	hsa-miR-3135b	81.3989	NM_001256182
ANKRD11	hsa-miR-3611	80.697	NM_001256182

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Motifs and transcription factors (TFs) regulating ANKRD11

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ANKRD11	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ANKRD11	cisbp__M00249	WT1 (directAnnotation).
ANKRD11	metacluster_182.10	ZFX (directAnnotation).
ANKRD11	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ANKRD11	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ANKRD11	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ANKRD11	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ANKRD11	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ANKRD11	transfac_pro__M01253	CNOT3 (directAnnotation).
ANKRD11	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ANKRD11	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ANKRD11	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ANKRD11	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ANKRD11	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ANKRD11	transfac_pro__M04817	ZBTB33 (directAnnotation).
ANKRD11	transfac_pro__M12697	ZNF142 (directAnnotation).
ANKRD11	tfdimers__MD00364	WT1 (directAnnotation).
ANKRD11	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ANKRD11	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ANKRD11	transfac_pro__M01973	PLAG1 (directAnnotation).
ANKRD11	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ANKRD11	tfdimers__MD00483	ZBTB14 (directAnnotation).
ANKRD11	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ANKRD11	metacluster_143.13	ZBTB7A (directAnnotation).
ANKRD11	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
ANKRD11	transfac_pro__M07387	ZBTB7A (directAnnotation).
ANKRD11	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ANKRD11	metacluster_144.13	HIC1; HIC1 (directAnnotation).
ANKRD11	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
ANKRD11	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
ANKRD11	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
ANKRD11	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ANKRD11	transfac_pro__M07329	SP7 (directAnnotation).
ANKRD11	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ANKRD11	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
ANKRD11	hocomoco__ZFX_MOUSE.H11MO.1.B	ZFY (inferredBy_Orthology).
ANKRD11	transfac_pro__M01122	ZNF219 (directAnnotation).
ANKRD11	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
ANKRD11	metacluster_3.10	KLF2; KLF4 (directAnnotation).
ANKRD11	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
ANKRD11	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
ANKRD11	tfdimers__MD00391	KLF4 (directAnnotation).
ANKRD11	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
ANKRD11	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
ANKRD11	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
ANKRD11	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
ANKRD11	jaspar__MA1483.2	ELF2 (directAnnotation).
ANKRD11	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNNNTAATKR_CAP_repr	DLX3; ETV2 (directAnnotation).
ANKRD11	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
ANKRD11	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."