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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: ACTR3

Summary for ACTR3

Gene information	Gene symbol	ACTR3
	Ensembl ID	ENSG00000115091
	Entrez ID	10096
	Gene name	actin related protein 3
	Synonyms	ARP3
	Gene type	protein_coding
	UniProtAcc	P61158

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Dataset with differentially expressed gene: ACTR3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	B cells	0.288155	2.01e-41
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.334636	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.436453	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	NK cells	-0.259783	7.24e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.584648	6.31e-28
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.250371	5.31e-08
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.306932	0.00e+00
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.269876	3.63e-40
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	CD8+ T cells	0.289622	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.267744	1.54e-04
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	CD8+ T cells	0.322541	5.63e-26
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.475593	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.303435	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.428538	3.36e-44
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	0.495152	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.24822	3.25e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.312781	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.490853	6.68e-05
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.282178	3.36e-15
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.443478	2.14e-39
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.551431	1.26e-37
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.345707	3.19e-19
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.319608	9.02e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.608857	0.00e+00

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Expression of ACTR3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ACTR3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ACTR3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ACTR3	hsa-miR-2115-3p	99.306	NM_001277140
ACTR3	hsa-miR-3671	99.1642	NM_001277140
ACTR3	hsa-miR-381-3p	98.4766	NM_001277140
ACTR3	hsa-miR-300	98.4766	NM_001277140
ACTR3	hsa-let-7f-1-3p	98.3215	NM_001277140
ACTR3	hsa-let-7b-3p	98.3215	NM_001277140
ACTR3	hsa-let-7a-3p	98.3215	NM_001277140
ACTR3	hsa-miR-98-3p	98.3215	NM_001277140
ACTR3	hsa-miR-4666a-3p	98.0585	NM_001277140
ACTR3	hsa-miR-12136	97.8043	NM_005721
ACTR3	hsa-miR-340-5p	96.063	NM_005721
ACTR3	hsa-miR-4744	94.1092	NM_005721
ACTR3	hsa-miR-4789-3p	94.0523	NM_005721
ACTR3	hsa-miR-125b-2-3p	92.3904	NM_001277140
ACTR3	hsa-miR-154-5p	90.9908	NM_005721
ACTR3	hsa-miR-3121-3p	90.6742	NM_005721
ACTR3	hsa-miR-670-3p	90.4174	NM_005721
ACTR3	hsa-miR-466	89.3978	NM_005721
ACTR3	hsa-miR-488-5p	88.8752	NM_005721
ACTR3	hsa-miR-4760-3p	88.7037	NM_005721
ACTR3	hsa-miR-4690-5p	88.5486	NM_005721
ACTR3	hsa-miR-4311	87.9612	NM_005721
ACTR3	hsa-miR-944	86.7445	NM_001277140
ACTR3	hsa-miR-485-5p	86.2908	NM_005721
ACTR3	hsa-miR-6884-5p	86.2908	NM_005721
ACTR3	hsa-miR-3973	86.1944	NM_005721
ACTR3	hsa-miR-190a-3p	85.1166	NM_005721
ACTR3	hsa-miR-607	84.3063	NM_005721
ACTR3	hsa-miR-5004-3p	84.2918	NM_005721
ACTR3	hsa-miR-551b-5p	84.2505	NM_005721
ACTR3	hsa-miR-511-5p	83.8941	NM_005721
ACTR3	hsa-miR-323a-3p	83.5237	NM_005721
ACTR3	hsa-miR-582-3p	83.1446	NM_005721
ACTR3	hsa-miR-302f	82.6044	NM_005721
ACTR3	hsa-miR-7109-5p	82.4906	NM_005721
ACTR3	hsa-miR-3133	82.2856	NM_005721
ACTR3	hsa-miR-374a-5p	82.1674	NM_005721
ACTR3	hsa-miR-3127-5p	82.0118	NM_005721
ACTR3	hsa-miR-605-5p	81.6377	NM_005721
ACTR3	hsa-miR-4694-5p	81.4707	NM_001277140
ACTR3	hsa-miR-550b-2-5p	81.4688	NM_005721
ACTR3	hsa-miR-548l	81.3591	NM_005721
ACTR3	hsa-miR-6074	80.8869	NM_005721
ACTR3	hsa-miR-6835-3p	80.8734	NM_001277140
ACTR3	hsa-miR-1277-5p	80.8064	NM_001277140
ACTR3	hsa-miR-7152-5p	80.679	NM_005721
ACTR3	hsa-miR-8067	80.6506	NM_005721
ACTR3	hsa-miR-6508-5p	80.4998	NM_005721
ACTR3	hsa-miR-5579-5p	80.397	NM_005721

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Motifs and transcription factors (TFs) regulating ACTR3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ACTR3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ACTR3	transfac_pro__M01303	SP1 (directAnnotation).
ACTR3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ACTR3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ACTR3	metacluster_3.14	WT1; WT1 (directAnnotation).
ACTR3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ACTR3	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
ACTR3	transfac_public__M00491	PATZ1 (directAnnotation).
ACTR3	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
ACTR3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ACTR3	transfac_pro__M07397	ZNF148 (directAnnotation).
ACTR3	transfac_pro__M05798	ZNF517 (directAnnotation).
ACTR3	transfac_pro__M05745	ZNF718 (directAnnotation).
ACTR3	metacluster_23.5	WT1 (directAnnotation).
ACTR3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ACTR3	transfac_pro__M04826	EP300 (directAnnotation).
ACTR3	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
ACTR3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
ACTR3	hdpi__ELF2	ELF2 (directAnnotation).
ACTR3	swissregulon__hs__ELK1	ELK1 (directAnnotation).
ACTR3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
ACTR3	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
ACTR3	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
ACTR3	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
ACTR3	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
ACTR3	transfac_pro__M01298	MECP2 (directAnnotation).
ACTR3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ACTR3	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
ACTR3	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
ACTR3	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
ACTR3	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
ACTR3	transfac_pro__M04748	GABPA (directAnnotation).
ACTR3	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ACTR3	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ACTR3	transfac_pro__M02089	E2F3 (directAnnotation).
ACTR3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ACTR3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ACTR3	transfac_pro__M04817	ZBTB33 (directAnnotation).
ACTR3	metacluster_143.13	ZBTB7A (directAnnotation).
ACTR3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ACTR3	tfdimers__MD00483	ZBTB14 (directAnnotation).
ACTR3	cisbp__M07938	E2F1 (directAnnotation).
ACTR3	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ACTR3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ACTR3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ACTR3	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ACTR3	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
ACTR3	transfac_pro__M01175	ZBTB7B (directAnnotation).
ACTR3	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
ACTR3	transfac_pro__M02090	E2F4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
ACTR3	"(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one"	DB08236	small molecule
ACTR3	"N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide"	DB08235	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."