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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFYVE16

Summary for ZFYVE16

Gene information	Gene symbol	ZFYVE16
	Ensembl ID	ENSG00000039319
	Entrez ID	9765
	Gene name	zinc finger FYVE-type containing 16
	Synonyms	KIAA0305\|PPP1R69
	Gene type	protein_coding
	UniProtAcc	Q7Z3T8

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Dataset with differentially expressed gene: ZFYVE16

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.295307	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.77546	0.00e+00

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Expression of ZFYVE16 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFYVE16

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFYVE16

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFYVE16	hsa-miR-513a-3p	99.3898	NM_014733
ZFYVE16	hsa-miR-513c-3p	99.3898	NM_014733
ZFYVE16	hsa-miR-3606-3p	99.1092	NM_014733
ZFYVE16	hsa-miR-380-3p	99.0396	NM_014733
ZFYVE16	hsa-miR-122b-5p	97.6113	NM_001105251
ZFYVE16	hsa-let-7a-3p	97.2549	NM_014733
ZFYVE16	hsa-let-7b-3p	97.2549	NM_014733
ZFYVE16	hsa-miR-98-3p	97.2549	NM_014733
ZFYVE16	hsa-let-7f-1-3p	97.2549	NM_014733
ZFYVE16	hsa-miR-607	97.1196	NM_001105251
ZFYVE16	hsa-miR-205-5p	96.4359	NM_014733
ZFYVE16	hsa-miR-580-5p	96.3663	NM_014733
ZFYVE16	hsa-miR-186-5p	95.0236	NM_001105251
ZFYVE16	hsa-miR-3163	94.8154	NM_001105251
ZFYVE16	hsa-miR-137-3p	93.7797	NM_001105251
ZFYVE16	hsa-miR-548v	93.6824	NM_001105251
ZFYVE16	hsa-miR-3194-3p	92.3691	NM_014733
ZFYVE16	hsa-miR-7-1-3p	90.77	NM_001105251
ZFYVE16	hsa-miR-7-2-3p	90.77	NM_001105251
ZFYVE16	hsa-miR-340-5p	90.7372	NM_001105251
ZFYVE16	hsa-miR-590-3p	90.5401	NM_001284237
ZFYVE16	hsa-miR-4760-5p	89.3583	NM_001284237
ZFYVE16	hsa-miR-3618	88.5975	NM_014733
ZFYVE16	hsa-miR-583	88.5429	NM_001105251
ZFYVE16	hsa-miR-1915-5p	88.2999	NM_001284237
ZFYVE16	hsa-miR-3919	87.7393	NM_014733
ZFYVE16	hsa-miR-4473	87.693	NM_001105251
ZFYVE16	hsa-miR-1253	87.5521	NM_014733
ZFYVE16	hsa-miR-188-3p	86.9794	NM_014733
ZFYVE16	hsa-miR-4775	86.8352	NM_001284237
ZFYVE16	hsa-miR-302c-5p	85.7962	NM_001105251
ZFYVE16	hsa-miR-589-3p	85.7389	NM_014733
ZFYVE16	hsa-miR-222-3p	85.0135	NM_001105251
ZFYVE16	hsa-miR-1276	84.5227	NM_001105251
ZFYVE16	hsa-miR-8061	84.3398	NM_001284237
ZFYVE16	hsa-miR-217-3p	82.7824	NM_014733
ZFYVE16	hsa-miR-766-5p	82.4914	NM_014733
ZFYVE16	hsa-miR-512-3p	82.2266	NM_014733
ZFYVE16	hsa-miR-6715b-5p	81.688	NM_014733
ZFYVE16	hsa-miR-4269	81.688	NM_014733
ZFYVE16	hsa-miR-4328	81.4238	NM_014733
ZFYVE16	hsa-miR-4252	81.0522	NM_014733
ZFYVE16	hsa-miR-552-5p	80.7299	NM_001105251
ZFYVE16	hsa-miR-103a-3p	80.6674	NM_001284237
ZFYVE16	hsa-miR-107	80.6674	NM_001284237
ZFYVE16	hsa-miR-221-3p	80.4879	NM_001105251
ZFYVE16	hsa-miR-6747-3p	80.3204	NM_014733
ZFYVE16	hsa-miR-4753-3p	80.3009	NM_014733
ZFYVE16	hsa-miR-6074	80.2417	NM_001284237

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Motifs and transcription factors (TFs) regulating ZFYVE16

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFYVE16	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ZFYVE16	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ZFYVE16	hdpi__ZNF304	ZNF304 (directAnnotation).
ZFYVE16	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ZFYVE16	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZFYVE16	transfac_pro__M04916	TAF1 (directAnnotation).
ZFYVE16	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
ZFYVE16	transfac_pro__M01973	PLAG1 (directAnnotation).
ZFYVE16	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
ZFYVE16	tfdimers__MD00483	ZBTB14 (directAnnotation).
ZFYVE16	metacluster_198.3	ZFP64 (directAnnotation).
ZFYVE16	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
ZFYVE16	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZFYVE16	transfac_pro__M01303	SP1 (directAnnotation).
ZFYVE16	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
ZFYVE16	metacluster_143.13	ZBTB7A (directAnnotation).
ZFYVE16	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
ZFYVE16	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
ZFYVE16	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
ZFYVE16	transfac_pro__M07387	ZBTB7A (directAnnotation).
ZFYVE16	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
ZFYVE16	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
ZFYVE16	metacluster_144.13	HIC1; HIC1 (directAnnotation).
ZFYVE16	transfac_pro__M00514	ATF4 (directAnnotation).
ZFYVE16	transfac_pro__M00665	SP3 (directAnnotation).
ZFYVE16	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZFYVE16	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
ZFYVE16	transfac_pro__M02898	SMAD3 (directAnnotation).
ZFYVE16	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
ZFYVE16	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZFYVE16	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZFYVE16	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
ZFYVE16	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZFYVE16	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
ZFYVE16	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
ZFYVE16	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
ZFYVE16	transfac_pro__M07329	SP7 (directAnnotation).
ZFYVE16	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
ZFYVE16	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZFYVE16	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
ZFYVE16	metacluster_126.4	ZNF12; ZNF12; ZNF44; ZNF563; ZNF93 (directAnnotation).
ZFYVE16	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
ZFYVE16	transfac_pro__M02089	E2F3 (directAnnotation).
ZFYVE16	cisbp__M07938	E2F1 (directAnnotation).
ZFYVE16	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZFYVE16	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
ZFYVE16	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."