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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZFR

Summary for ZFR

Gene information	Gene symbol	ZFR
	Ensembl ID	ENSG00000056097
	Entrez ID	51663
	Gene name	zinc finger RNA binding protein
	Synonyms	SPG71\|ZFR1
	Gene type	protein_coding
	UniProtAcc	Q96KR1

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Dataset with differentially expressed gene: ZFR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.253798	0.00e+00
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.276992	1.24e-10
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.396179	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.27779	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.351746	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.473162	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.427273	2.81e-37

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Expression of ZFR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ZFR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ZFR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZFR	hsa-miR-141-3p	99.5454	NM_016107
ZFR	hsa-miR-200a-3p	99.5454	NM_016107
ZFR	hsa-miR-6502-3p	97.8606	NM_016107
ZFR	hsa-miR-4699-5p	97.7847	NM_016107
ZFR	hsa-miR-153-5p	96.4695	NM_016107
ZFR	hsa-miR-889-3p	96.4172	NM_016107
ZFR	hsa-miR-330-3p	96.2723	NM_016107
ZFR	hsa-miR-524-5p	96.2349	NM_016107
ZFR	hsa-miR-520d-5p	96.2349	NM_016107
ZFR	hsa-miR-369-3p	96.0804	NM_016107
ZFR	hsa-miR-6501-3p	95.6355	NM_016107
ZFR	hsa-miR-1537-5p	95.4411	NM_016107
ZFR	hsa-miR-6776-5p	94.7808	NM_016107
ZFR	hsa-miR-9902	93.8039	NM_016107
ZFR	hsa-miR-4775	93.4528	NM_016107
ZFR	hsa-miR-190a-3p	92.8069	NM_016107
ZFR	hsa-miR-5692a	92.5119	NM_016107
ZFR	hsa-miR-3163	91.7044	NM_016107
ZFR	hsa-miR-2467-3p	91.4417	NM_016107
ZFR	hsa-miR-208b-5p	90.5525	NM_016107
ZFR	hsa-miR-208a-5p	90.5525	NM_016107
ZFR	hsa-miR-5010-3p	89.1967	NM_016107
ZFR	hsa-miR-1208	88.816	NM_016107
ZFR	hsa-miR-4795-3p	88.5107	NM_016107
ZFR	hsa-miR-4696	88.4884	NM_016107
ZFR	hsa-miR-17-3p	88.4572	NM_016107
ZFR	hsa-miR-4709-5p	88.3916	NM_016107
ZFR	hsa-miR-586	87.3739	NM_016107
ZFR	hsa-miR-4652-3p	87.3385	NM_016107
ZFR	hsa-miR-3613-3p	86.7977	NM_016107
ZFR	hsa-miR-5688	86.6681	NM_016107
ZFR	hsa-miR-3529-3p	86.5523	NM_016107
ZFR	hsa-miR-548x-3p	86.3867	NM_016107
ZFR	hsa-miR-548aj-3p	86.3867	NM_016107
ZFR	hsa-miR-10527-5p	86.3574	NM_016107
ZFR	hsa-miR-5689	86.1584	NM_016107
ZFR	hsa-miR-548aq-3p	85.4754	NM_016107
ZFR	hsa-miR-548ah-3p	85.4754	NM_016107
ZFR	hsa-miR-548j-3p	85.4754	NM_016107
ZFR	hsa-miR-548am-3p	85.4754	NM_016107
ZFR	hsa-miR-548ae-3p	85.4754	NM_016107
ZFR	hsa-miR-3158-5p	84.9885	NM_016107
ZFR	hsa-miR-7150	84.7814	NM_016107
ZFR	hsa-miR-892c-5p	84.7478	NM_016107
ZFR	hsa-miR-4436b-5p	84.6971	NM_016107
ZFR	hsa-miR-548ar-3p	84.5672	NM_016107
ZFR	hsa-miR-7-1-3p	84.1496	NM_016107
ZFR	hsa-miR-7-2-3p	84.1496	NM_016107
ZFR	hsa-miR-549a-3p	83.923	NM_016107
ZFR	hsa-miR-4801	83.5061	NM_016107

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Motifs and transcription factors (TFs) regulating ZFR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZFR	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
ZFR	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
ZFR	transfac_pro__M06213	ZNF267 (directAnnotation).
ZFR	transfac_pro__M06035	ZNF749 (directAnnotation).
ZFR	transfac_pro__M01861	ATF1 (directAnnotation).
ZFR	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
ZFR	jaspar__MA1596.1	ZNF460 (directAnnotation).
ZFR	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
ZFR	metacluster_35.7	HINFP (inferredBy_Orthology).
ZFR	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ZFR	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ZFR	cisbp__M00968	MTF2 (directAnnotation).
ZFR	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ZFR	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ZFR	cisbp__M00341	PAX6 (directAnnotation).
ZFR	metacluster_198.3	ZFP64 (directAnnotation).
ZFR	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ZFR	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
ZFR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
ZFR	cisbp__M00788	ZFY (inferredBy_Orthology).
ZFR	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
ZFR	metacluster_175.1	ZNF283 (directAnnotation).
ZFR	hdpi__ZNF304	ZNF304 (directAnnotation).
ZFR	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZFR	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZFR	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZFR	transfac_pro__M01199	TRIM28 (directAnnotation).
ZFR	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
ZFR	metacluster_151.2	ZNF23 (directAnnotation).
ZFR	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZFR	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZFR	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZFR	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ZFR	transfac_pro__M02913	SP140 (inferredBy_Orthology).
ZFR	jaspar__MA0748.2	YY2 (directAnnotation).
ZFR	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ZFR	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ZFR	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ZFR	transfac_pro__M00430	E2F1 (directAnnotation).
ZFR	transfac_pro__M04893	TAF1 (directAnnotation).
ZFR	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
ZFR	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
ZFR	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
ZFR	hdpi__HIP2	UBE2K (directAnnotation).
ZFR	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
ZFR	hdpi__TIMELESS	TIMELESS (directAnnotation).
ZFR	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ZFR	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ZFR	metacluster_191.5	SPDEF (inferredBy_Orthology).
ZFR	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."