Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ZC3HAV1

Summary for ZC3HAV1

Gene information	Gene symbol	ZC3HAV1
	Ensembl ID	ENSG00000105939
	Entrez ID	56829
	Gene name	zinc finger CCCH-type containing, antiviral 1
	Synonyms	ARTD13\|FLB6421\|FLJ13288\|MGC48898\|PARP13\|ZAP\|ZC3H2\|ZC3HDC2
	Gene type	protein_coding
	UniProtAcc	Q7Z2W4

Top

Dataset with differentially expressed gene: ZC3HAV1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.362462	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.288091	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.292837	1.35e-07
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.341859	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.400532	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.304478	1.64e-11
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.375844	2.31e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD4+ T cells	0.35654	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	pDCs	1.34852	7.34e-07
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.295906	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.4597	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.47746	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.410275	2.58e-04
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.345369	1.88e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.262376	8.13e-25

Top

Expression of ZC3HAV1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ZC3HAV1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ZC3HAV1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ZC3HAV1	hsa-miR-4457	92.2013	NM_024625
ZC3HAV1	hsa-miR-4288	92.0076	NM_020119
ZC3HAV1	hsa-miR-550b-3p	91.8501	NM_024625
ZC3HAV1	hsa-miR-4329	89.6876	NM_020119
ZC3HAV1	hsa-miR-6807-5p	89.6571	NM_020119
ZC3HAV1	hsa-miR-150-5p	88.194	NM_020119
ZC3HAV1	hsa-miR-632	87.0613	NM_020119
ZC3HAV1	hsa-miR-3148	85.8642	NM_020119
ZC3HAV1	hsa-miR-3682-5p	85.655	NM_020119
ZC3HAV1	hsa-miR-885-5p	85.051	NM_020119
ZC3HAV1	hsa-miR-371b-5p	84.9072	NM_020119
ZC3HAV1	hsa-miR-616-5p	84.9072	NM_020119
ZC3HAV1	hsa-miR-373-5p	84.9072	NM_020119
ZC3HAV1	hsa-miR-4272	83.9713	NM_020119
ZC3HAV1	hsa-miR-4778-5p	83.409	NM_020119
ZC3HAV1	hsa-miR-148b-5p	83.1127	NM_020119
ZC3HAV1	hsa-miR-6874-3p	83.1127	NM_020119
ZC3HAV1	hsa-miR-3130-5p	83.046	NM_024625
ZC3HAV1	hsa-miR-4482-5p	83.046	NM_024625
ZC3HAV1	hsa-miR-5590-5p	82.5437	NM_020119
ZC3HAV1	hsa-miR-7152-5p	82.3558	NM_020119
ZC3HAV1	hsa-miR-27b-5p	81.7669	NM_020119
ZC3HAV1	hsa-miR-6786-3p	81.2045	NM_020119
ZC3HAV1	hsa-miR-6809-3p	81.0363	NM_020119
ZC3HAV1	hsa-miR-4775	80.5409	NM_020119
ZC3HAV1	hsa-miR-545-3p	80.0106	NM_024625

Page: 1

Top

Motifs and transcription factors (TFs) regulating ZC3HAV1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ZC3HAV1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ZC3HAV1	transfac_pro__M04893	TAF1 (directAnnotation).
ZC3HAV1	transfac_pro__M04916	TAF1 (directAnnotation).
ZC3HAV1	cisbp__M08228	PAX5 (directAnnotation).
ZC3HAV1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
ZC3HAV1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
ZC3HAV1	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
ZC3HAV1	transfac_pro__M02090	E2F4 (directAnnotation).
ZC3HAV1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZC3HAV1	metacluster_175.1	ZNF283 (directAnnotation).
ZC3HAV1	cisbp__M00343	PAX6 (directAnnotation).
ZC3HAV1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
ZC3HAV1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ZC3HAV1	transfac_pro__M12694	ZFP14 (directAnnotation).
ZC3HAV1	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
ZC3HAV1	transfac_pro__M02898	SMAD3 (directAnnotation).
ZC3HAV1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ZC3HAV1	transfac_pro__M08005	TCFL5 (inferredBy_Orthology).
ZC3HAV1	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
ZC3HAV1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ZC3HAV1	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
ZC3HAV1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
ZC3HAV1	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
ZC3HAV1	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ZC3HAV1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
ZC3HAV1	transfac_pro__M03806	ZBTB7C (directAnnotation).
ZC3HAV1	metacluster_135.11	NR2C2 (directAnnotation).
ZC3HAV1	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
ZC3HAV1	transfac_pro__M07437	ZBTB2 (directAnnotation).
ZC3HAV1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ZC3HAV1	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
ZC3HAV1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
ZC3HAV1	transfac_public__M00446	SPZ1 (directAnnotation).
ZC3HAV1	hdpi__OTUD4	OTUD4 (directAnnotation).
ZC3HAV1	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
ZC3HAV1	transfac_pro__M06545	ZNF485 (directAnnotation).
ZC3HAV1	taipale_tf_pairs__TEAD4_HOXA2_RCATTCNNNNNNCATTA_CAP	HOXA2; TEAD4 (directAnnotation).
ZC3HAV1	transfac_pro__M06556	ZNF383 (directAnnotation).
ZC3HAV1	transfac_pro__M06617	ZNF480 (directAnnotation).
ZC3HAV1	metacluster_80.6	ZIC4 (directAnnotation).
ZC3HAV1	transfac_pro__M06314	ZNF239 (directAnnotation).
ZC3HAV1	hocomoco__GMEB2_HUMAN.H11MO.0.D	GMEB2 (directAnnotation).
ZC3HAV1	taipale_cyt_meth__JUND_NRTGACGCATN_eDBD_repr	JUND (directAnnotation).
ZC3HAV1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
ZC3HAV1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ZC3HAV1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
ZC3HAV1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
ZC3HAV1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."