Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: YWHAH

Summary for YWHAH

Gene information	Gene symbol	YWHAH
	Ensembl ID	ENSG00000128245
	Entrez ID	7533
	Gene name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
	Synonyms	YWHA1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: YWHAH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.404635	4.06e-32
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	0.37653	2.55e-23
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.508198	2.48e-11
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.728323	3.87e-08
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.307744	1.95e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	0.621396	7.65e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.966582	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.313433	8.66e-21
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.349729	1.26e-02
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.524774	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.28125	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.30204	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.484479	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.300877	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.26749	6.69e-16
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.291159	4.53e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.588156	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.724978	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.305489	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.348523	2.50e-07
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.576406	0.00e+00

Top

Expression of YWHAH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to YWHAH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating YWHAH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YWHAH	hsa-miR-33b-5p	98.5626	NM_003405
YWHAH	hsa-miR-33a-5p	98.5626	NM_003405
YWHAH	hsa-miR-4729	98.1022	NM_003405
YWHAH	hsa-miR-320c	96.8352	NM_003405
YWHAH	hsa-miR-320b	96.8352	NM_003405
YWHAH	hsa-miR-320d	96.8352	NM_003405
YWHAH	hsa-miR-320a-3p	96.8352	NM_003405
YWHAH	hsa-miR-4429	96.8352	NM_003405
YWHAH	hsa-miR-4641	95.3718	NM_003405
YWHAH	hsa-miR-1323	94.7838	NM_003405
YWHAH	hsa-miR-548o-3p	93.7925	NM_003405
YWHAH	hsa-miR-4801	93.572	NM_003405
YWHAH	hsa-miR-6769b-5p	93.4051	NM_003405
YWHAH	hsa-miR-6809-5p	92.6018	NM_003405
YWHAH	hsa-miR-583	92.3931	NM_003405
YWHAH	hsa-miR-6769a-5p	90.8236	NM_003405
YWHAH	hsa-miR-4731-3p	90.3783	NM_003405
YWHAH	hsa-miR-3613-3p	89.5051	NM_003405
YWHAH	hsa-miR-4474-3p	87.8696	NM_003405
YWHAH	hsa-miR-6748-5p	87.6	NM_003405
YWHAH	hsa-miR-585-5p	87.5102	NM_003405
YWHAH	hsa-miR-5682	87.5102	NM_003405
YWHAH	hsa-miR-4666b	87.3453	NM_003405
YWHAH	hsa-miR-7110-5p	86.0025	NM_003405
YWHAH	hsa-miR-6842-5p	86.0025	NM_003405
YWHAH	hsa-miR-6838-5p	85.8673	NM_003405
YWHAH	hsa-miR-424-5p	85.8673	NM_003405
YWHAH	hsa-miR-15b-5p	85.8673	NM_003405
YWHAH	hsa-miR-16-5p	85.8673	NM_003405
YWHAH	hsa-miR-195-5p	85.8673	NM_003405
YWHAH	hsa-miR-497-5p	85.8673	NM_003405
YWHAH	hsa-miR-15a-5p	85.8673	NM_003405
YWHAH	hsa-miR-4709-3p	85.7139	NM_003405
YWHAH	hsa-miR-5011-3p	84.809	NM_003405
YWHAH	hsa-miR-3688-5p	83.8093	NM_003405
YWHAH	hsa-miR-6752-5p	82.9749	NM_003405
YWHAH	hsa-miR-7108-5p	82.5617	NM_003405
YWHAH	hsa-miR-8062	81.5819	NM_003405
YWHAH	hsa-miR-654-5p	81.3063	NM_003405
YWHAH	hsa-miR-541-3p	81.3063	NM_003405
YWHAH	hsa-miR-7162-5p	80.7563	NM_003405
YWHAH	hsa-miR-516a-3p	80.7563	NM_003405
YWHAH	hsa-miR-516b-3p	80.7563	NM_003405
YWHAH	hsa-miR-587	80.5898	NM_003405

Page: 1

Top

Motifs and transcription factors (TFs) regulating YWHAH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YWHAH	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
YWHAH	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
YWHAH	transfac_pro__M03806	ZBTB7C (directAnnotation).
YWHAH	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
YWHAH	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
YWHAH	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
YWHAH	cisbp__M00249	WT1 (directAnnotation).
YWHAH	cisbp__M01863	ZNF711 (inferredBy_Orthology).
YWHAH	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
YWHAH	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
YWHAH	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
YWHAH	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
YWHAH	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
YWHAH	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
YWHAH	transfac_pro__M02913	SP140 (inferredBy_Orthology).
YWHAH	swissregulon__hs__ELF2	ELF2 (directAnnotation).
YWHAH	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
YWHAH	cisbp__M08198	ELF1 (directAnnotation).
YWHAH	transfac_pro__M04748	GABPA (directAnnotation).
YWHAH	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
YWHAH	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
YWHAH	transfac_pro__M01122	ZNF219 (directAnnotation).
YWHAH	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
YWHAH	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
YWHAH	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
YWHAH	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
YWHAH	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
YWHAH	metacluster_84.2	RARA (directAnnotation).
YWHAH	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
YWHAH	transfac_pro__M01253	CNOT3 (directAnnotation).
YWHAH	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
YWHAH	metacluster_3.10	KLF2; KLF4 (directAnnotation).
YWHAH	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
YWHAH	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
YWHAH	swissregulon__hs__CHD1	CHD1 (directAnnotation).
YWHAH	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
YWHAH	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
YWHAH	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
YWHAH	tfdimers__MD00151	CHURC1 (directAnnotation).
YWHAH	tfdimers__MD00391	KLF4 (directAnnotation).
YWHAH	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
YWHAH	transfac_pro__M01973	PLAG1 (directAnnotation).
YWHAH	transfac_pro__M12697	ZNF142 (directAnnotation).
YWHAH	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
YWHAH	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YWHAH	transfac_pro__M01303	SP1 (directAnnotation).
YWHAH	metacluster_3.14	WT1; WT1 (directAnnotation).
YWHAH	transfac_public__M00491	PATZ1 (directAnnotation).
YWHAH	transfac_pro__M07397	ZNF148 (directAnnotation).
YWHAH	jaspar__MA1708.1	ETV7 (directAnnotation).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
YWHAH	"Phenethyl Isothiocyanate"	DB12695	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."