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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: YTHDC1

Summary for YTHDC1

Gene information	Gene symbol	YTHDC1
	Ensembl ID	ENSG00000275272
	Entrez ID	91746
	Gene name	YTH domain containing 1
	Synonyms	KIAA1966\|YT521\|YT521-B
	Gene type	protein_coding
	UniProtAcc	Q96MU7

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Dataset with differentially expressed gene: YTHDC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-1.0965	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.325612	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.269717	5.39e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.26892	1.61e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.504862	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.466972	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.583216	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.494702	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.325451	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.291624	1.09e-15
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.382594	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.261527	0.00e+00

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Expression of YTHDC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to YTHDC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating YTHDC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
YTHDC1	hsa-miR-4724-5p	98.8683	NM_001031732
YTHDC1	hsa-miR-3613-3p	98.7493	NM_133370
YTHDC1	hsa-miR-3668	98.5176	NM_133370
YTHDC1	hsa-miR-217-5p	97.0812	NM_001031732
YTHDC1	hsa-miR-543	96.8531	NM_001031732
YTHDC1	hsa-miR-548t-5p	96.3089	NM_133370
YTHDC1	hsa-miR-548az-5p	96.3089	NM_133370
YTHDC1	hsa-miR-5688	96.2452	NM_001031732
YTHDC1	hsa-miR-495-3p	96.1127	NM_001031732
YTHDC1	hsa-miR-3934-5p	95.9018	NM_133370
YTHDC1	hsa-miR-6807-3p	95.3464	NM_001031732
YTHDC1	hsa-miR-6740-3p	94.1115	NM_133370
YTHDC1	hsa-miR-3908	93.6062	NM_001031732
YTHDC1	hsa-miR-300	92.7936	NM_001031732
YTHDC1	hsa-miR-381-3p	92.7936	NM_001031732
YTHDC1	hsa-miR-1913	92.7076	NM_133370
YTHDC1	hsa-miR-16-5p	92.3012	NM_001031732
YTHDC1	hsa-miR-15b-5p	92.3012	NM_001031732
YTHDC1	hsa-miR-15a-5p	92.3012	NM_001031732
YTHDC1	hsa-miR-195-5p	92.3012	NM_001031732
YTHDC1	hsa-miR-4524a-5p	92.1049	NM_001031732
YTHDC1	hsa-miR-4524b-5p	92.1049	NM_001031732
YTHDC1	hsa-miR-1-5p	91.491	NM_133370
YTHDC1	hsa-miR-424-5p	90.7339	NM_001031732
YTHDC1	hsa-miR-6838-5p	90.7339	NM_001031732
YTHDC1	hsa-miR-497-5p	90.7339	NM_001031732
YTHDC1	hsa-miR-335-3p	90.1124	NM_133370
YTHDC1	hsa-miR-618	89.4597	NM_133370
YTHDC1	hsa-miR-33a-3p	89.304	NM_133370
YTHDC1	hsa-miR-4730	88.8635	NM_133370
YTHDC1	hsa-miR-548c-3p	88.8604	NM_001031732
YTHDC1	hsa-miR-8485	88.8146	NM_133370
YTHDC1	hsa-miR-548au-3p	88.8059	NM_001031732
YTHDC1	hsa-miR-4738-3p	88.32	NM_133370
YTHDC1	hsa-miR-4714-5p	88.2872	NM_133370
YTHDC1	hsa-miR-6884-5p	88.0563	NM_001031732
YTHDC1	hsa-miR-145-5p	87.9549	NM_001031732
YTHDC1	hsa-miR-5195-3p	87.9549	NM_001031732
YTHDC1	hsa-miR-5699-5p	87.2126	NM_133370
YTHDC1	hsa-miR-4709-3p	85.9433	NM_001031732
YTHDC1	hsa-let-7b-3p	85.2869	NM_133370
YTHDC1	hsa-let-7a-3p	85.2869	NM_133370
YTHDC1	hsa-let-7f-1-3p	85.2869	NM_133370
YTHDC1	hsa-miR-98-3p	85.2869	NM_133370
YTHDC1	hsa-miR-485-5p	84.8037	NM_001031732
YTHDC1	hsa-miR-4703-5p	84.212	NM_001031732
YTHDC1	hsa-miR-103a-3p	84.0983	NM_001031732
YTHDC1	hsa-miR-107	84.0983	NM_001031732
YTHDC1	hsa-miR-1843	83.2104	NM_133370
YTHDC1	hsa-miR-4802-5p	83.2104	NM_133370

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Motifs and transcription factors (TFs) regulating YTHDC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
YTHDC1	hdpi__HIP2	UBE2K (directAnnotation).
YTHDC1	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
YTHDC1	hdpi__TIMELESS	TIMELESS (directAnnotation).
YTHDC1	metacluster_191.5	SPDEF (inferredBy_Orthology).
YTHDC1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
YTHDC1	transfac_pro__M00938	E2F1 (directAnnotation).
YTHDC1	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
YTHDC1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
YTHDC1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
YTHDC1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
YTHDC1	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
YTHDC1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
YTHDC1	transfac_pro__M02898	SMAD3 (directAnnotation).
YTHDC1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
YTHDC1	cisbp__M00249	WT1 (directAnnotation).
YTHDC1	transfac_pro__M00430	E2F1 (directAnnotation).
YTHDC1	hdpi__TP73	TP73 (directAnnotation).
YTHDC1	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
YTHDC1	metacluster_101.3	MYB (directAnnotation).
YTHDC1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
YTHDC1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
YTHDC1	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
YTHDC1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
YTHDC1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
YTHDC1	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
YTHDC1	transfac_pro__M01973	PLAG1 (directAnnotation).
YTHDC1	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
YTHDC1	transfac_pro__M00514	ATF4 (directAnnotation).
YTHDC1	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
YTHDC1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
YTHDC1	metacluster_182.10	ZFX (directAnnotation).
YTHDC1	metacluster_111.3	ATF1; ATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREM; CREM; CREM; CREM; E4F1; E4F1 (directAnnotation). CREB1; CREB1; CREM; JDP2 (inferredBy_Orthology).
YTHDC1	transfac_pro__M01861	ATF1 (directAnnotation).
YTHDC1	jaspar__MA1933.1	SREBF2 (directAnnotation).
YTHDC1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
YTHDC1	cisbp__M08198	ELF1 (directAnnotation).
YTHDC1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
YTHDC1	taipale_tf_pairs__JUN_ATGACGTCAT_HT	JUN (directAnnotation).
YTHDC1	metacluster_161.4	LHX9 (directAnnotation).
YTHDC1	transfac_public__M00041	ATF2; JUN (directAnnotation).
YTHDC1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
YTHDC1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
YTHDC1	transfac_pro__M01249	EPAS1 (directAnnotation).
YTHDC1	transfac_pro__M06135	ZNF28 (directAnnotation).
YTHDC1	metacluster_71.2	EPAS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."