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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: XPO7

Summary for XPO7

Gene information	Gene symbol	XPO7
	Ensembl ID	ENSG00000130227
	Entrez ID	23039
	Gene name	exportin 7
	Synonyms	EXP7\|KIAA0745\|RANBP16
	Gene type	protein_coding
	UniProtAcc	Q9UIA9

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Dataset with differentially expressed gene: XPO7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.256415	1.57e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.532085	1.09e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.318283	1.44e-04
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.365281	1.26e-44

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Expression of XPO7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to XPO7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating XPO7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
XPO7	hsa-miR-4725-3p	96.9442	NM_015024
XPO7	hsa-miR-6780b-5p	96.9442	NM_015024
XPO7	hsa-miR-4271	96.2622	NM_015024
XPO7	hsa-miR-3135b	95.1394	NM_015024
XPO7	hsa-miR-3148	94.9633	NM_015024
XPO7	hsa-miR-940	94.4846	NM_015024
XPO7	hsa-miR-6808-5p	94.4846	NM_015024
XPO7	hsa-miR-6893-5p	94.4846	NM_015024
XPO7	hsa-miR-216b-3p	93.8943	NM_015024
XPO7	hsa-miR-3160-3p	93.146	NM_015024
XPO7	hsa-miR-937-5p	92.9823	NM_015024
XPO7	hsa-miR-497-5p	92.9037	NM_015024
XPO7	hsa-miR-6780a-3p	92.8788	NM_015024
XPO7	hsa-miR-4698	92.8755	NM_015024
XPO7	hsa-miR-15a-5p	92.3681	NM_015024
XPO7	hsa-miR-195-5p	92.3681	NM_015024
XPO7	hsa-miR-15b-5p	92.3681	NM_015024
XPO7	hsa-miR-16-5p	92.3681	NM_015024
XPO7	hsa-miR-4700-5p	92.2235	NM_015024
XPO7	hsa-miR-424-5p	91.6066	NM_015024
XPO7	hsa-miR-6838-5p	91.6066	NM_015024
XPO7	hsa-miR-1972	90.7804	NM_015024
XPO7	hsa-miR-331-3p	90.4901	NM_015024
XPO7	hsa-miR-377-3p	90.0383	NM_015024
XPO7	hsa-miR-6831-5p	89.855	NM_015024
XPO7	hsa-miR-4667-5p	88.9881	NM_015024
XPO7	hsa-miR-4704-3p	88.8476	NM_015024
XPO7	hsa-miR-4701-5p	88.7652	NM_015024
XPO7	hsa-miR-588	88.7652	NM_015024
XPO7	hsa-miR-8089	88.7356	NM_015024
XPO7	hsa-miR-4262	88.6422	NM_015024
XPO7	hsa-miR-12113	88.373	NM_015024
XPO7	hsa-miR-3059-5p	88.3703	NM_015024
XPO7	hsa-miR-624-3p	88.3626	NM_015024
XPO7	hsa-miR-584-5p	87.9758	NM_015024
XPO7	hsa-miR-12119	87.5164	NM_015024
XPO7	hsa-miR-381-3p	87.2585	NM_015024
XPO7	hsa-miR-300	87.2585	NM_015024
XPO7	hsa-miR-1252-5p	86.6225	NM_015024
XPO7	hsa-miR-7-5p	85.4921	NM_015024
XPO7	hsa-miR-3927-3p	85.4873	NM_015024
XPO7	hsa-miR-3125	85.4584	NM_015024
XPO7	hsa-miR-4784	84.7001	NM_015024
XPO7	hsa-miR-3150b-3p	84.7001	NM_015024
XPO7	hsa-miR-3916	84.6179	NM_015024
XPO7	hsa-miR-6859-5p	84.6179	NM_015024
XPO7	hsa-miR-597-5p	84.5037	NM_015024
XPO7	hsa-miR-4653-3p	84.1933	NM_015024
XPO7	hsa-miR-6836-5p	83.9277	NM_015024
XPO7	hsa-miR-6132	83.9277	NM_015024

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Motifs and transcription factors (TFs) regulating XPO7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
XPO7	metacluster_143.13	ZBTB7A (directAnnotation).
XPO7	transfac_pro__M05845	ZSCAN29 (directAnnotation).
XPO7	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
XPO7	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
XPO7	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
XPO7	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
XPO7	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
XPO7	jaspar__MA1122.1	TFDP1 (directAnnotation).
XPO7	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
XPO7	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
XPO7	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
XPO7	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
XPO7	transfac_pro__M01175	ZBTB7B (directAnnotation).
XPO7	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
XPO7	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
XPO7	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
XPO7	metacluster_3.14	WT1; WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."