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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: XPO1

Summary for XPO1

Gene information	Gene symbol	XPO1
	Ensembl ID	ENSG00000082898
	Entrez ID	7514
	Gene name	exportin 1
	Synonyms	CRM-1\|CRM1\|emb
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: XPO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.621912	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.292706	7.44e-09
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.289509	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.41503	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.361448	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.314969	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.415368	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	-0.333996	9.39e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.385252	8.57e-18

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Expression of XPO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to XPO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating XPO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
XPO1	hsa-miR-30e-5p	99.4281	NM_003400
XPO1	hsa-miR-30a-5p	99.4281	NM_003400
XPO1	hsa-miR-30b-5p	99.4281	NM_003400
XPO1	hsa-miR-30c-5p	99.4281	NM_003400
XPO1	hsa-miR-30d-5p	99.4281	NM_003400
XPO1	hsa-miR-6885-3p	96.5876	NM_003400
XPO1	hsa-miR-4495	96.0527	NM_003400
XPO1	hsa-miR-4775	94.3709	NM_003400
XPO1	hsa-miR-3678-3p	94.0554	NM_003400
XPO1	hsa-miR-455-3p	93.3179	NM_003400
XPO1	hsa-miR-6862-5p	93.2998	NM_003400
XPO1	hsa-miR-4253	93.2998	NM_003400
XPO1	hsa-miR-4255	92.8254	NM_003400
XPO1	hsa-miR-4444	92.6698	NM_003400
XPO1	hsa-miR-892a	92.6183	NM_003400
XPO1	hsa-miR-7106-3p	92.5903	NM_003400
XPO1	hsa-miR-3680-3p	92.5861	NM_003400
XPO1	hsa-miR-4533	92.4753	NM_003400
XPO1	hsa-miR-412-5p	92.3497	NM_003400
XPO1	hsa-miR-4789-3p	90.7137	NM_003400
XPO1	hsa-miR-4478	90.3838	NM_003400
XPO1	hsa-miR-4282	90.159	NM_003400
XPO1	hsa-miR-4642	90.0983	NM_003400
XPO1	hsa-miR-4284	89.2262	NM_003400
XPO1	hsa-miR-645	87.9341	NM_003400
XPO1	hsa-miR-3915	87.9033	NM_003400
XPO1	hsa-miR-3929	87.7954	NM_003400
XPO1	hsa-miR-6126	87.1839	NM_003400
XPO1	hsa-miR-3945	86.4963	NM_003400
XPO1	hsa-miR-142-3p	86.2858	NM_003400
XPO1	hsa-miR-190a-5p	86.1174	NM_003400
XPO1	hsa-miR-190b-5p	86.1174	NM_003400
XPO1	hsa-miR-552-5p	85.7559	NM_003400
XPO1	hsa-miR-27a-3p	85.2834	NM_003400
XPO1	hsa-miR-9985	85.2834	NM_003400
XPO1	hsa-miR-27b-3p	85.2834	NM_003400
XPO1	hsa-miR-513a-5p	85.2834	NM_003400
XPO1	hsa-miR-3613-3p	84.5441	NM_003400
XPO1	hsa-let-7a-3p	84.455	NM_003400
XPO1	hsa-let-7f-1-3p	84.455	NM_003400
XPO1	hsa-miR-98-3p	84.455	NM_003400
XPO1	hsa-let-7b-3p	84.455	NM_003400
XPO1	hsa-miR-133a-3p	84.3798	NM_003400
XPO1	hsa-miR-133b	84.3798	NM_003400
XPO1	hsa-miR-300	83.641	NM_003400
XPO1	hsa-miR-381-3p	83.641	NM_003400
XPO1	hsa-miR-5187-5p	82.893	NM_003400
XPO1	hsa-miR-548ao-5p	82.6297	NM_003400
XPO1	hsa-miR-548ax	82.6297	NM_003400
XPO1	hsa-miR-571	81.6452	NM_003400

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Motifs and transcription factors (TFs) regulating XPO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
XPO1	hocomoco__FOXJ3_HUMAN.H11MO.1.B	FOXJ3 (directAnnotation).
XPO1	transfac_pro__M02089	E2F3 (directAnnotation).
XPO1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
XPO1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
XPO1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
XPO1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
XPO1	hdpi__NRL	NRL (directAnnotation).
XPO1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
XPO1	transfac_pro__M07329	SP7 (directAnnotation).
XPO1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
XPO1	transfac_pro__M07397	ZNF148 (directAnnotation).
XPO1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
XPO1	cisbp__M07938	E2F1 (directAnnotation).
XPO1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
XPO1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
XPO1	transfac_pro__M07436	WT1 (directAnnotation).
XPO1	metacluster_3.14	WT1; WT1 (directAnnotation).
XPO1	transfac_pro__M01837	KLF11 (directAnnotation).
XPO1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
XPO1	transfac_pro__M07310	SP5 (directAnnotation).
XPO1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
XPO1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
XPO1	transfac_pro__M04817	ZBTB33 (directAnnotation).
XPO1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
XPO1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
XPO1	transfac_pro__M01175	ZBTB7B (directAnnotation).
XPO1	transfac_pro__M00716	ZBTB14 (directAnnotation).
XPO1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
XPO1	transfac_pro__M07297	MAZ (directAnnotation).
XPO1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
XPO1	cisbp__M00968	MTF2 (directAnnotation).
XPO1	metacluster_163.2	ZNF682 (directAnnotation).
XPO1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
XPO1	transfac_pro__M04916	TAF1 (directAnnotation).
XPO1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
XPO1	metacluster_3.3	KLF10; KLF15; KLF16; KLF9; SP1 (directAnnotation).
XPO1	transfac_pro__M02090	E2F4 (directAnnotation).
XPO1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
XPO1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
XPO1	transfac_pro__M01303	SP1 (directAnnotation).
XPO1	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
XPO1	transfac_pro__M01249	EPAS1 (directAnnotation).
XPO1	jaspar__MA1117.1	RELB (directAnnotation).
XPO1	metacluster_71.2	EPAS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
XPO1	"Selinexor"	DB11942	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."