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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WWTR1

Summary for WWTR1

Gene information	Gene symbol	WWTR1
	Ensembl ID	ENSG00000018408
	Entrez ID	25937
	Gene name	WW domain containing transcription regulator 1
	Synonyms	DKFZp586I1419\|TAZ
	Gene type	protein_coding
	UniProtAcc	Q9GZV5

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Dataset with differentially expressed gene: WWTR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.28365	1.49e-29
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.32051	4.03e-14
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.968201	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.457237	0.00e+00

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Expression of WWTR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WWTR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WWTR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WWTR1	hsa-miR-9-3p	99.3308	NM_001168278
WWTR1	hsa-miR-12136	97.7347	NM_015472
WWTR1	hsa-miR-3121-3p	97.6879	NM_001168278
WWTR1	hsa-miR-376b-3p	97.3522	NM_015472
WWTR1	hsa-miR-376a-3p	97.3522	NM_015472
WWTR1	hsa-miR-335-3p	97.0011	NM_015472
WWTR1	hsa-miR-5692a	96.69	NM_001168278
WWTR1	hsa-miR-200a-3p	96.0774	NM_001168278
WWTR1	hsa-miR-141-3p	96.0774	NM_001168278
WWTR1	hsa-miR-4645-5p	96.0415	NM_001168278
WWTR1	hsa-miR-4673	96.0415	NM_001168278
WWTR1	hsa-miR-3613-3p	95.8128	NM_001168278
WWTR1	hsa-miR-7152-5p	95.0965	NM_001168278
WWTR1	hsa-miR-3919	95.0816	NM_001168278
WWTR1	hsa-miR-130b-5p	94.8366	NM_001168278
WWTR1	hsa-miR-3690	94.426	NM_001168278
WWTR1	hsa-miR-224-3p	94.1555	NM_015472
WWTR1	hsa-miR-522-3p	94.1555	NM_015472
WWTR1	hsa-miR-1911-3p	92.1684	NM_001168278
WWTR1	hsa-miR-5682	91.0896	NM_001168278
WWTR1	hsa-miR-6819-5p	90.8813	NM_015472
WWTR1	hsa-miR-6737-5p	90.8813	NM_015472
WWTR1	hsa-miR-4276	90.8477	NM_015472
WWTR1	hsa-miR-3158-5p	90.0089	NM_015472
WWTR1	hsa-miR-4422	89.84	NM_001168278
WWTR1	hsa-miR-4756-3p	89.6493	NM_001168278
WWTR1	hsa-miR-548ao-5p	89.1559	NM_015472
WWTR1	hsa-miR-548ax	89.1559	NM_015472
WWTR1	hsa-miR-6812-5p	89.1044	NM_015472
WWTR1	hsa-miR-17-3p	88.0921	NM_015472
WWTR1	hsa-miR-624-5p	88.0795	NM_001168278
WWTR1	hsa-miR-10523-5p	87.3384	NM_015472
WWTR1	hsa-miR-5690	86.9828	NM_015472
WWTR1	hsa-miR-4255	85.7211	NM_015472
WWTR1	hsa-miR-6780b-3p	85.4917	NM_001168278
WWTR1	hsa-miR-29a-3p	85.3354	NM_001168278
WWTR1	hsa-miR-29b-3p	85.3354	NM_001168278
WWTR1	hsa-miR-29c-3p	85.3354	NM_001168278
WWTR1	hsa-miR-340-5p	84.9986	NM_001168278
WWTR1	hsa-miR-513b-5p	84.5759	NM_015472
WWTR1	hsa-miR-146a-3p	84.2119	NM_001168278
WWTR1	hsa-miR-4252	83.5904	NM_015472
WWTR1	hsa-miR-3664-5p	83.2397	NM_015472
WWTR1	hsa-miR-1258	82.1561	NM_015472
WWTR1	hsa-miR-144-3p	81.8353	NM_001168278
WWTR1	hsa-miR-101-3p	81.8353	NM_001168278
WWTR1	hsa-miR-3194-3p	81.6582	NM_015472
WWTR1	hsa-miR-664b-3p	81.3436	NM_015472
WWTR1	hsa-miR-579-3p	81.3436	NM_015472
WWTR1	hsa-miR-450b-5p	81.0721	NM_001168278

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Motifs and transcription factors (TFs) regulating WWTR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WWTR1	hdpi__ETV4	ETV4 (directAnnotation).
WWTR1	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
WWTR1	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
WWTR1	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
WWTR1	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."