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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WNK1

Summary for WNK1

Gene information	Gene symbol	WNK1
	Ensembl ID	ENSG00000060237
	Entrez ID	65125
	Gene name	WNK lysine deficient protein kinase 1
	Synonyms	HSAN2\|HSN2\|PPP1R167\|PRKWNK1
	Gene type	protein_coding
	UniProtAcc	Q9H4A3

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Dataset with differentially expressed gene: WNK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.277837	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.309537	1.90e-06
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.282996	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.274806	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.270554	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.309632	4.63e-14
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	0.335089	6.10e-30
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.401998	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.44761	2.58e-11
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.254767	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.266902	7.75e-12
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.324883	4.29e-16
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.595252	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.515249	0.00e+00

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Expression of WNK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WNK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WNK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WNK1	hsa-miR-651-3p	99.5276	NM_213655
WNK1	hsa-miR-29b-2-5p	99.2976	NM_014823
WNK1	hsa-miR-5692a	98.0969	NM_014823
WNK1	hsa-miR-892c-5p	98.0127	NM_014823
WNK1	hsa-miR-4671-3p	96.2182	NM_014823
WNK1	hsa-miR-4657	96.0228	NM_213655
WNK1	hsa-miR-4491	96.0228	NM_213655
WNK1	hsa-miR-3692-3p	95.4519	NM_213655
WNK1	hsa-miR-19a-3p	95.3373	NM_014823
WNK1	hsa-miR-19b-3p	95.3373	NM_014823
WNK1	hsa-miR-200a-3p	94.5247	NM_014823
WNK1	hsa-miR-141-3p	94.5247	NM_014823
WNK1	hsa-miR-3124-3p	94.3225	NM_213655
WNK1	hsa-miR-4698	94.0802	NM_014823
WNK1	hsa-miR-4473	92.8935	NM_014823
WNK1	hsa-miR-6833-5p	92.8491	NM_213655
WNK1	hsa-miR-1913	92.665	NM_014823
WNK1	hsa-miR-454-3p	92.5188	NM_014823
WNK1	hsa-miR-301a-3p	92.3725	NM_014823
WNK1	hsa-miR-4295	92.3725	NM_014823
WNK1	hsa-miR-301b-3p	92.3725	NM_014823
WNK1	hsa-miR-130a-3p	92.3725	NM_014823
WNK1	hsa-miR-3666	92.3725	NM_014823
WNK1	hsa-miR-130b-3p	92.3725	NM_014823
WNK1	hsa-miR-5010-3p	92.1944	NM_213655
WNK1	hsa-miR-383-3p	91.5406	NM_014823
WNK1	hsa-miR-128-3p	91.4182	NM_014823
WNK1	hsa-miR-216a-3p	91.4182	NM_014823
WNK1	hsa-miR-3177-5p	91.2527	NM_014823
WNK1	hsa-miR-4709-5p	90.1506	NM_213655
WNK1	hsa-miR-5688	89.8626	NM_213655
WNK1	hsa-miR-4790-3p	89.855	NM_213655
WNK1	hsa-miR-3148	89.7493	NM_014823
WNK1	hsa-miR-3681-3p	89.5274	NM_014823
WNK1	hsa-miR-3927-5p	89.251	NM_014823
WNK1	hsa-miR-3618	89.2266	NM_014823
WNK1	hsa-miR-192-5p	89.2127	NM_014823
WNK1	hsa-miR-215-5p	89.2127	NM_014823
WNK1	hsa-miR-520d-5p	88.7505	NM_014823
WNK1	hsa-miR-524-5p	88.7505	NM_014823
WNK1	hsa-miR-1297	88.7309	NM_014823
WNK1	hsa-miR-1244	88.5699	NM_213655
WNK1	hsa-miR-299-5p	88.5157	NM_014823
WNK1	hsa-miR-4520-2-3p	88.3614	NM_213655
WNK1	hsa-miR-4729	88.2354	NM_014823
WNK1	hsa-miR-222-5p	87.8095	NM_014823
WNK1	hsa-miR-26b-5p	87.7739	NM_014823
WNK1	hsa-miR-26a-5p	87.7739	NM_014823
WNK1	hsa-miR-23a-3p	87.6782	NM_014823
WNK1	hsa-miR-23c	87.6782	NM_014823

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Motifs and transcription factors (TFs) regulating WNK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WNK1	cisbp__M00788	ZFY (inferredBy_Orthology).
WNK1	hdpi__ZNF304	ZNF304 (directAnnotation).
WNK1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
WNK1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
WNK1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
WNK1	transfac_pro__M01199	TRIM28 (directAnnotation).
WNK1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
WNK1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WNK1	transfac_pro__M03806	ZBTB7C (directAnnotation).
WNK1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
WNK1	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
WNK1	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
WNK1	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
WNK1	transfac_pro__M01968	FOXO1 (directAnnotation).
WNK1	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
WNK1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGNNNNNNYMATTA_CAP	ETV2; HOXA2 (directAnnotation).
WNK1	transfac_pro__M06280	ZFP69 (directAnnotation).
WNK1	transfac_pro__M05990	ZNF69 (directAnnotation).
WNK1	metacluster_144.10	ZNF100 (directAnnotation).
WNK1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
WNK1	cisbp__M00249	WT1 (directAnnotation).
WNK1	transfac_pro__M01122	ZNF219 (directAnnotation).
WNK1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
WNK1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
WNK1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
WNK1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
WNK1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
WNK1	transfac_pro__M01253	CNOT3 (directAnnotation).
WNK1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
WNK1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
WNK1	jaspar__MA1721.1	ZNF93 (directAnnotation).
WNK1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
WNK1	jaspar__MA1122.1	TFDP1 (directAnnotation).
WNK1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
WNK1	tfdimers__MD00391	KLF4 (directAnnotation).
WNK1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
WNK1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
WNK1	transfac_pro__M01973	PLAG1 (directAnnotation).
WNK1	transfac_pro__M12697	ZNF142 (directAnnotation).
WNK1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
WNK1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
WNK1	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
WNK1	tfdimers__MD00339	HMGA1; HMGA2; TFAP2C (directAnnotation).
WNK1	transfac_pro__M04817	ZBTB33 (directAnnotation).
WNK1	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
WNK1	tfdimers__MD00411	ELF5; YY1 (directAnnotation).
WNK1	metacluster_32.25	ZNF287 (directAnnotation).
WNK1	dbtfbs__ZSCAN16_HEK293_ENCSR864VJE_merged_N1	ZSCAN16 (directAnnotation).
WNK1	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
WNK1	transfac_pro__M05521	ZNF398 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."