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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: WIPF1

Summary for WIPF1

Gene information	Gene symbol	WIPF1
	Ensembl ID	ENSG00000115935
	Entrez ID	7456
	Gene name	WAS/WASL interacting protein family member 1
	Synonyms	WASPIP\|WIP
	Gene type	protein_coding
	UniProtAcc	O43516

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Dataset with differentially expressed gene: WIPF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.280584	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.32584	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.32902	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.439859	9.28e-19
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	CD4+ T cells	0.260151	0.00e+00
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	NK cells	0.281788	2.71e-32
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.414102	8.70e-09
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.398701	9.86e-42
GSE164237	patients	Peripheral blood mononuclear cells	Melanoma	Advanced stages of melanoma	Immunotherapy	pembrolizumab	pre	CD8+ T cells	-0.289204	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.388043	2.16e-15
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.26379	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.344799	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.633087	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.27135	0.00e+00

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Expression of WIPF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WIPF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating WIPF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WIPF1	hsa-miR-3163	99.766	NM_001077269
WIPF1	hsa-miR-200c-3p	99.2486	NM_001077269
WIPF1	hsa-miR-200b-3p	99.2486	NM_001077269
WIPF1	hsa-miR-429	99.2486	NM_001077269
WIPF1	hsa-miR-5680	99.1286	NM_001077269
WIPF1	hsa-miR-3942-3p	95.1324	NM_003387
WIPF1	hsa-miR-203a-5p	93.8417	NM_001077269
WIPF1	hsa-miR-4282	93.7181	NM_001077269
WIPF1	hsa-miR-7-2-3p	93.231	NM_001077269
WIPF1	hsa-miR-7-1-3p	93.231	NM_001077269
WIPF1	hsa-miR-6500-3p	91.5005	NM_003387
WIPF1	hsa-miR-6809-5p	91.2347	NM_001077269
WIPF1	hsa-miR-153-3p	89.8906	NM_001077269
WIPF1	hsa-miR-607	89.8884	NM_001077269
WIPF1	hsa-miR-4283	89.7256	NM_003387
WIPF1	hsa-miR-4790-3p	89.6471	NM_003387
WIPF1	hsa-miR-494-3p	89.0822	NM_003387
WIPF1	hsa-miR-12117	89.0014	NM_001077269
WIPF1	hsa-miR-5688	88.5094	NM_001077269
WIPF1	hsa-miR-124-3p	88.1882	NM_001077269
WIPF1	hsa-miR-506-3p	88.1882	NM_001077269
WIPF1	hsa-miR-593-5p	86.9416	NM_001077269
WIPF1	hsa-miR-9851-3p	86.9416	NM_001077269
WIPF1	hsa-miR-495-3p	86.5711	NM_001077269
WIPF1	hsa-miR-1266-5p	86.365	NM_003387
WIPF1	hsa-miR-4518	86.365	NM_003387
WIPF1	hsa-miR-2681-5p	85.3941	NM_001077269
WIPF1	hsa-miR-30b-5p	85.3898	NM_001077269
WIPF1	hsa-miR-30a-5p	85.3898	NM_001077269
WIPF1	hsa-miR-30d-5p	85.3898	NM_001077269
WIPF1	hsa-miR-30e-5p	85.3898	NM_001077269
WIPF1	hsa-miR-30c-5p	85.3898	NM_001077269
WIPF1	hsa-miR-6504-3p	85.2684	NM_003387
WIPF1	hsa-miR-10399-5p	85.2684	NM_003387
WIPF1	hsa-miR-655-3p	85.2389	NM_001077269
WIPF1	hsa-miR-374c-5p	85.2389	NM_001077269
WIPF1	hsa-miR-6797-5p	85.1335	NM_003387
WIPF1	hsa-miR-1249-5p	85.1335	NM_003387
WIPF1	hsa-miR-12128	84.5078	NM_003387
WIPF1	hsa-miR-4519	84.4811	NM_003387
WIPF1	hsa-miR-1277-5p	83.945	NM_003387
WIPF1	hsa-miR-3646	83.8605	NM_003387
WIPF1	hsa-miR-4668-5p	82.6686	NM_001077269
WIPF1	hsa-miR-1231	82.1111	NM_003387
WIPF1	hsa-miR-5700	81.3462	NM_003387
WIPF1	hsa-miR-3121-3p	81.1796	NM_001077269
WIPF1	hsa-miR-524-5p	80.9103	NM_001077269
WIPF1	hsa-miR-520d-5p	80.9103	NM_001077269
WIPF1	hsa-miR-3119	80.868	NM_001077269
WIPF1	hsa-miR-4779	80.7474	NM_003387

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Motifs and transcription factors (TFs) regulating WIPF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WIPF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
WIPF1	metacluster_191.5	SPDEF (inferredBy_Orthology).
WIPF1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
WIPF1	hdpi__TIMELESS	TIMELESS (directAnnotation).
WIPF1	transfac_pro__M04893	TAF1 (directAnnotation).
WIPF1	cisbp__M00249	WT1 (directAnnotation).
WIPF1	transfac_pro__M00430	E2F1 (directAnnotation).
WIPF1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
WIPF1	hdpi__ZNF304	ZNF304 (directAnnotation).
WIPF1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
WIPF1	transfac_pro__M00938	E2F1 (directAnnotation).
WIPF1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
WIPF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
WIPF1	metacluster_161.4	LHX9 (directAnnotation).
WIPF1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
WIPF1	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
WIPF1	metacluster_161.3	LHX9 (directAnnotation).
WIPF1	metacluster_2.6	IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF1; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF2; IRF3; IRF3; IRF3; IRF3; IRF3; IRF3; IRF4; IRF4; IRF4; IRF4; IRF4; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF5; IRF6; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF7; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF8; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; IRF9; STAT1; STAT2; STAT2; STAT2; STAT2; ZNF426; ZNF71 (directAnnotation). IRF1; IRF1; IRF3; IRF8 (inferredBy_Orthology).
WIPF1	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
WIPF1	metacluster_32.25	ZNF287 (directAnnotation).
WIPF1	dbtfbs__ZSCAN16_HEK293_ENCSR864VJE_merged_N1	ZSCAN16 (directAnnotation).
WIPF1	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
WIPF1	transfac_pro__M05521	ZNF398 (directAnnotation).
WIPF1	taipale_tf_pairs__FOXO1_ELF1_NNGAAAACCGAANM_CAP	ELF1; FOXO1 (directAnnotation).
WIPF1	transfac_pro__M06592	ZNF486 (directAnnotation).
WIPF1	cisbp__M00767	ZSCAN10 (inferredBy_Orthology).
WIPF1	transfac_public__M00051	NFKB1 (directAnnotation).
WIPF1	hdpi__NRL	NRL (directAnnotation).
WIPF1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
WIPF1	hdpi__FEZF2	FEZF2 (directAnnotation).
WIPF1	transfac_pro__M07310	SP5 (directAnnotation).
WIPF1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
WIPF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
WIPF1	metacluster_155.11	SPZ1 (directAnnotation).
WIPF1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
WIPF1	hdpi__HTATIP2	HTATIP2 (directAnnotation).
WIPF1	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
WIPF1	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
WIPF1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
WIPF1	cisbp__M07938	E2F1 (directAnnotation).
WIPF1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
WIPF1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
WIPF1	tfdimers__MD00483	ZBTB14 (directAnnotation).
WIPF1	transfac_pro__M07317	CTBP1 (directAnnotation).
WIPF1	transfac_pro__M12697	ZNF142 (directAnnotation).
WIPF1	transfac_pro__M00716	ZBTB14 (directAnnotation).
WIPF1	transfac_pro__M03806	ZBTB7C (directAnnotation).
WIPF1	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
WIPF1	transfac_pro__M04916	TAF1 (directAnnotation).
WIPF1	hdpi__RARA	RARA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."