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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: WEE1

Summary for WEE1

Gene information	Gene symbol	WEE1
	Ensembl ID	ENSG00000166483
	Entrez ID	7465
	Gene name	WEE1 G2 checkpoint kinase
	Synonyms	WEE1A
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: WEE1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.734671	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.568762	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.525552	4.87e-35
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.576473	6.34e-03

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Expression of WEE1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to WEE1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
WEE1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating WEE1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
WEE1	hsa-miR-513b-5p	99.3795	NM_001143976
WEE1	hsa-miR-3120-3p	98.9793	NM_001143976
WEE1	hsa-miR-15b-5p	97.3879	NM_001143976
WEE1	hsa-miR-15a-5p	97.3879	NM_001143976
WEE1	hsa-miR-195-5p	97.3879	NM_001143976
WEE1	hsa-miR-16-5p	97.3879	NM_001143976
WEE1	hsa-miR-6882-5p	97.0802	NM_001143976
WEE1	hsa-miR-646	97.0758	NM_001143976
WEE1	hsa-miR-6838-5p	96.8525	NM_001143976
WEE1	hsa-miR-424-5p	96.8525	NM_001143976
WEE1	hsa-miR-497-5p	96.8525	NM_001143976
WEE1	hsa-miR-655-3p	95.4627	NM_001143976
WEE1	hsa-miR-374c-5p	95.4627	NM_001143976
WEE1	hsa-miR-4801	95.2578	NM_001143976
WEE1	hsa-miR-651-3p	95.1662	NM_001143976
WEE1	hsa-miR-4789-5p	95.072	NM_001143976
WEE1	hsa-miR-4731-3p	94.5597	NM_001143976
WEE1	hsa-miR-1305	94.2247	NM_001143976
WEE1	hsa-miR-144-3p	94.064	NM_001143976
WEE1	hsa-miR-4524b-5p	93.9618	NM_001143976
WEE1	hsa-miR-4524a-5p	93.9618	NM_001143976
WEE1	hsa-miR-4760-3p	93.5812	NM_001143976
WEE1	hsa-miR-155-5p	93.1161	NM_001143976
WEE1	hsa-miR-4445-5p	92.9383	NM_001143976
WEE1	hsa-miR-545-3p	92.4486	NM_001143976
WEE1	hsa-miR-5582-3p	92.2455	NM_001143976
WEE1	hsa-miR-4320	90.7057	NM_001143976
WEE1	hsa-miR-4676-5p	88.7238	NM_001143976
WEE1	hsa-miR-575	88.7238	NM_001143976
WEE1	hsa-miR-503-5p	88.6055	NM_001143976
WEE1	hsa-miR-219a-5p	87.9974	NM_001143976
WEE1	hsa-miR-6766-3p	87.9974	NM_001143976
WEE1	hsa-miR-4782-3p	87.9974	NM_001143976
WEE1	hsa-miR-508-3p	87.9974	NM_001143976
WEE1	hsa-miR-4719	87.7405	NM_001143976
WEE1	hsa-miR-196a-1-3p	87.2807	NM_001143976
WEE1	hsa-miR-3148	87.0896	NM_001143976
WEE1	hsa-miR-4709-3p	87.0468	NM_001143976
WEE1	hsa-miR-4295	86.9609	NM_001143976
WEE1	hsa-miR-106b-5p	86.3713	NM_001143976
WEE1	hsa-miR-106a-5p	86.3713	NM_001143976
WEE1	hsa-miR-216a-3p	86.1043	NM_001143976
WEE1	hsa-miR-128-3p	86.1043	NM_001143976
WEE1	hsa-miR-944	86.0251	NM_001143976
WEE1	hsa-miR-17-5p	85.5735	NM_001143976
WEE1	hsa-miR-130a-3p	84.6755	NM_001143976
WEE1	hsa-miR-301b-3p	84.6755	NM_001143976
WEE1	hsa-miR-3666	84.6755	NM_001143976
WEE1	hsa-miR-301a-3p	84.6755	NM_001143976
WEE1	hsa-miR-130b-3p	84.6755	NM_001143976

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Motifs and transcription factors (TFs) regulating WEE1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
WEE1	transfac_pro__M00430	E2F1 (directAnnotation).
WEE1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
WEE1	transfac_pro__M07329	SP7 (directAnnotation).
WEE1	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
WEE1	transfac_pro__M07397	ZNF148 (directAnnotation).
WEE1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
WEE1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
WEE1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
WEE1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
WEE1	transfac_pro__M07436	WT1 (directAnnotation).
WEE1	metacluster_3.14	WT1; WT1 (directAnnotation).
WEE1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
WEE1	transfac_pro__M01837	KLF11 (directAnnotation).
WEE1	transfac_pro__M07310	SP5 (directAnnotation).
WEE1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
WEE1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
WEE1	jaspar__MA0748.2	YY2 (directAnnotation).
WEE1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
WEE1	transfac_pro__M00716	ZBTB14 (directAnnotation).
WEE1	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
WEE1	jaspar__MA1122.1	TFDP1 (directAnnotation).
WEE1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
WEE1	metacluster_163.2	ZNF682 (directAnnotation).
WEE1	transfac_pro__M04916	TAF1 (directAnnotation).
WEE1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
WEE1	transfac_pro__M00938	E2F1 (directAnnotation).
WEE1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
WEE1	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
WEE1	"3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID"	DB07265	small molecule
WEE1	"4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione"	DB07257	small molecule
WEE1	"8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]in	DB08365	small molecule
WEE1	"9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE"	DB04608	small molecule
WEE1	"9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE"	DB07006	small molecule
WEE1	"Fostamatinib"	DB12010	small molecule
WEE1	"MK-1775"	DB11740	small molecule
WEE1	"N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE"	DB07226	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."