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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: VPS13A

Summary for VPS13A

Gene information	Gene symbol	VPS13A
	Ensembl ID	ENSG00000197969
	Entrez ID	23230
	Gene name	vacuolar protein sorting 13 homolog A
	Synonyms	BLTP5A\|CHAC\|KIAA0986
	Gene type	protein_coding
	UniProtAcc	Q96RL7

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Dataset with differentially expressed gene: VPS13A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.46552	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.324916	0.00e+00

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Expression of VPS13A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VPS13A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VPS13A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VPS13A	hsa-miR-3163	99.4291	NM_015186
VPS13A	hsa-miR-4795-3p	99.3955	NM_015186
VPS13A	hsa-miR-126-5p	98.7922	NM_015186
VPS13A	hsa-miR-501-5p	94.704	NM_001018037
VPS13A	hsa-miR-4774-5p	94.6406	NM_001018038
VPS13A	hsa-miR-586	93.7229	NM_001018037
VPS13A	hsa-miR-4425	92.6416	NM_001018037
VPS13A	hsa-miR-6079	91.9846	NM_001018037
VPS13A	hsa-miR-6885-3p	90.5895	NM_015186
VPS13A	hsa-miR-31-3p	90.2362	NM_001018037
VPS13A	hsa-miR-3126-3p	89.1972	NM_001018037
VPS13A	hsa-miR-6844	89.1302	NM_001018038
VPS13A	hsa-miR-3664-5p	88.7162	NM_001018037
VPS13A	hsa-miR-499a-5p	88.2014	NM_001018038
VPS13A	hsa-miR-5580-3p	87.8715	NM_015186
VPS13A	hsa-miR-541-5p	87.7059	NM_001018038
VPS13A	hsa-miR-10395-3p	87.0219	NM_001018038
VPS13A	hsa-miR-605-3p	87.0043	NM_015186
VPS13A	hsa-miR-8068	86.5541	NM_001018037
VPS13A	hsa-miR-18b-5p	86.0149	NM_001018037
VPS13A	hsa-miR-18a-5p	86.0149	NM_001018037
VPS13A	hsa-miR-7157-3p	85.9805	NM_015186
VPS13A	hsa-miR-6737-3p	85.9805	NM_015186
VPS13A	hsa-miR-3919	85.8851	NM_001018037
VPS13A	hsa-miR-6841-5p	85.8684	NM_001018037
VPS13A	hsa-miR-3662	85.528	NM_015186
VPS13A	hsa-miR-5008-3p	85.144	NM_015186
VPS13A	hsa-miR-208a-5p	84.0704	NM_001018037
VPS13A	hsa-miR-208b-5p	84.0704	NM_001018037
VPS13A	hsa-miR-3915	83.8049	NM_001018037
VPS13A	hsa-miR-1248	83.6832	NM_001018038
VPS13A	hsa-miR-885-5p	83.5557	NM_001018037
VPS13A	hsa-miR-4735-3p	82.7159	NM_001018037
VPS13A	hsa-miR-651-3p	82.0097	NM_001018037
VPS13A	hsa-miR-3133	81.728	NM_001018037
VPS13A	hsa-miR-3529-3p	81.689	NM_001018037
VPS13A	hsa-miR-5692a	81.4652	NM_001018037
VPS13A	hsa-miR-4742-3p	81.4407	NM_001018037
VPS13A	hsa-miR-1825	81.1414	NM_001018038
VPS13A	hsa-miR-140-3p	80.8304	NM_001018038
VPS13A	hsa-miR-497-3p	80.3612	NM_001018038

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Motifs and transcription factors (TFs) regulating VPS13A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VPS13A	transfac_pro__M00938	E2F1 (directAnnotation).
VPS13A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
VPS13A	transfac_pro__M02090	E2F4 (directAnnotation).
VPS13A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
VPS13A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
VPS13A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
VPS13A	transfac_pro__M01303	SP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."