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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: VDAC1

Summary for VDAC1

Gene information	Gene symbol	VDAC1
	Ensembl ID	ENSG00000213585
	Entrez ID	7416
	Gene name	voltage dependent anion channel 1
	Synonyms	MGC111064\|PORIN
	Gene type	protein_coding
	UniProtAcc	P21796

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Dataset with differentially expressed gene: VDAC1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.356652	2.44e-30
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	0.259417	1.91e-04
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.453547	1.42e-32
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.477516	1.64e-26
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.270959	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.274151	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.487053	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.292756	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.660293	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.663233	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-1.0095	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.262767	2.67e-10
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.371902	1.34e-27
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.699575	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.279249	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.510264	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.777238	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.580983	0.00e+00

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Expression of VDAC1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to VDAC1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating VDAC1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
VDAC1	hsa-miR-3529-3p	96.461	NM_003374
VDAC1	hsa-miR-183-5p	95.8114	NM_003374
VDAC1	hsa-miR-16-2-3p	94.1157	NM_003374
VDAC1	hsa-miR-195-3p	94.1157	NM_003374
VDAC1	hsa-miR-1468-3p	92.6071	NM_003374
VDAC1	hsa-miR-548av-3p	92.2113	NM_003374
VDAC1	hsa-miR-324-5p	91.881	NM_003374
VDAC1	hsa-miR-5003-5p	90.9113	NM_003374
VDAC1	hsa-miR-1297	89.9831	NM_003374
VDAC1	hsa-miR-6895-5p	89.4081	NM_003374
VDAC1	hsa-miR-7161-5p	89.2609	NM_003374
VDAC1	hsa-miR-4310	89.0344	NM_003374
VDAC1	hsa-miR-26a-5p	88.5426	NM_003374
VDAC1	hsa-miR-26b-5p	88.5426	NM_003374
VDAC1	hsa-miR-10399-5p	88.0435	NM_003374
VDAC1	hsa-miR-6504-3p	88.0435	NM_003374
VDAC1	hsa-miR-4272	88.0298	NM_003374
VDAC1	hsa-miR-6864-5p	87.347	NM_003374
VDAC1	hsa-miR-6755-3p	86.9356	NM_003374
VDAC1	hsa-miR-7-5p	86.4372	NM_003374
VDAC1	hsa-miR-320b	86.3741	NM_003374
VDAC1	hsa-miR-320a-3p	86.3741	NM_003374
VDAC1	hsa-miR-320c	86.3741	NM_003374
VDAC1	hsa-miR-320d	86.3741	NM_003374
VDAC1	hsa-miR-4429	86.3741	NM_003374
VDAC1	hsa-miR-548u	86.16	NM_003374
VDAC1	hsa-miR-5197-5p	85.8887	NM_003374
VDAC1	hsa-miR-7157-5p	84.9878	NM_003374
VDAC1	hsa-miR-3120-3p	84.7928	NM_003374
VDAC1	hsa-miR-660-5p	84.6266	NM_003374
VDAC1	hsa-miR-4758-5p	83.9818	NM_003374
VDAC1	hsa-miR-1238-5p	83.9818	NM_003374
VDAC1	hsa-miR-4465	83.885	NM_003374
VDAC1	hsa-miR-4777-5p	83.8042	NM_003374
VDAC1	hsa-miR-7156-3p	83.7485	NM_003374
VDAC1	hsa-miR-6838-3p	82.8092	NM_003374
VDAC1	hsa-miR-9-3p	81.3065	NM_003374
VDAC1	hsa-miR-577	80.7613	NM_003374

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Motifs and transcription factors (TFs) regulating VDAC1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
VDAC1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
VDAC1	tfdimers__MD00151	CHURC1 (directAnnotation).
VDAC1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
VDAC1	cisbp__M00968	MTF2 (directAnnotation).
VDAC1	transfac_pro__M12697	ZNF142 (directAnnotation).
VDAC1	transfac_pro__M01303	SP1 (directAnnotation).
VDAC1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
VDAC1	metacluster_3.14	WT1; WT1 (directAnnotation).
VDAC1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
VDAC1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
VDAC1	transfac_pro__M06894	ZFP90 (inferredBy_Orthology).
VDAC1	transfac_pro__M01182	HINFP (directAnnotation).
VDAC1	taipale_cyt_meth__SMAD5_YGTCTAGACA_eDBD_meth_repr	SMAD5 (directAnnotation).
VDAC1	metacluster_172.6	CHD2; E2F1 (directAnnotation).
VDAC1	metacluster_91.2	SMAD3; SMAD5 (directAnnotation).
VDAC1	taipale_tf_pairs__FOXJ3_ELF1_NNARAAAACCGAAWMN_CAP	ELF1; FOXJ3 (directAnnotation).
VDAC1	taipale_tf_pairs__GCM1_HOXB13_NCCCGCANNMATAAA_CAP_repr	GCM1; HOXB13 (directAnnotation).
VDAC1	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
VDAC1	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
VDAC1	metacluster_161.4	LHX9 (directAnnotation).
VDAC1	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
VDAC1	metacluster_161.3	LHX9 (directAnnotation).
VDAC1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
VDAC1	transfac_pro__M02089	E2F3 (directAnnotation).
VDAC1	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
VDAC1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
VDAC1	transfac_pro__M04817	ZBTB33 (directAnnotation).
VDAC1	tfdimers__MD00483	ZBTB14 (directAnnotation).
VDAC1	cisbp__M07938	E2F1 (directAnnotation).
VDAC1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
VDAC1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
VDAC1	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
VDAC1	hdpi__MYEF2	MYEF2 (directAnnotation).
VDAC1	metacluster_131.6	EGR2; EGR4 (directAnnotation). EGR2; EGR3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
VDAC1	"Aluminium monostearate"	DB01375	small molecule
VDAC1	"Cannabidiol"	DB09061	small molecule
VDAC1	"Medical Cannabis"	DB14009	biotech
VDAC1	"Nabiximols"	DB14011	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."