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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UTP3

Summary for UTP3

Gene information	Gene symbol	UTP3
	Ensembl ID	ENSG00000132467
	Entrez ID	57050
	Gene name	UTP3 small subunit processome component
	Synonyms	CRLZ1\|DKFZp761F222\|FLJ23256\|SAS10
	Gene type	protein_coding
	UniProtAcc	Q9NQZ2

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Dataset with differentially expressed gene: UTP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.654048	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.258517	1.29e-08
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.737826	0.00e+00

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Expression of UTP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UTP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UTP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UTP3	hsa-miR-4282	96.8769	NM_020368
UTP3	hsa-miR-4753-3p	95.6645	NM_020368
UTP3	hsa-miR-10523-5p	94.7345	NM_020368
UTP3	hsa-miR-5584-3p	93.0126	NM_020368
UTP3	hsa-miR-548n	91.5896	NM_020368
UTP3	hsa-miR-559	86.3677	NM_020368
UTP3	hsa-miR-548o-5p	85.8137	NM_020368
UTP3	hsa-miR-548j-5p	85.8137	NM_020368
UTP3	hsa-miR-548aq-5p	85.8137	NM_020368
UTP3	hsa-miR-548au-5p	85.8137	NM_020368
UTP3	hsa-miR-548ab	85.8137	NM_020368
UTP3	hsa-miR-548ap-5p	85.8137	NM_020368
UTP3	hsa-miR-548ae-5p	85.8137	NM_020368
UTP3	hsa-miR-548ad-5p	85.8137	NM_020368
UTP3	hsa-miR-548y	85.8137	NM_020368
UTP3	hsa-miR-548h-5p	85.8137	NM_020368
UTP3	hsa-miR-548c-5p	85.8137	NM_020368
UTP3	hsa-miR-548a-5p	85.8137	NM_020368
UTP3	hsa-miR-548i	85.8137	NM_020368
UTP3	hsa-miR-548d-5p	85.8137	NM_020368
UTP3	hsa-miR-548ak	85.8137	NM_020368
UTP3	hsa-miR-548ar-5p	85.8137	NM_020368
UTP3	hsa-miR-548bb-5p	85.8137	NM_020368
UTP3	hsa-miR-548b-5p	85.8137	NM_020368
UTP3	hsa-miR-548as-5p	85.8137	NM_020368
UTP3	hsa-miR-548w	85.8137	NM_020368
UTP3	hsa-miR-548ay-5p	85.8137	NM_020368
UTP3	hsa-miR-548am-5p	85.8137	NM_020368
UTP3	hsa-miR-3136-3p	82.6575	NM_020368
UTP3	hsa-miR-7155-3p	82.6575	NM_020368
UTP3	hsa-miR-3138	81.9032	NM_020368
UTP3	hsa-miR-190a-3p	81.7305	NM_020368
UTP3	hsa-miR-640	80.5819	NM_020368

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Motifs and transcription factors (TFs) regulating UTP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UTP3	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
UTP3	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."