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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: USP9X

Summary for USP9X

Gene information	Gene symbol	USP9X
	Ensembl ID	ENSG00000124486
	Entrez ID	8239
	Gene name	ubiquitin specific peptidase 9 X-linked
	Synonyms	DFFRX\|FAF\|MRX99
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: USP9X

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.481224	1.12e-44
GSE131984_Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	NA	Malignant cells	-0.278287	3.43e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.285594	2.48e-07
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.263369	4.52e-27
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.549855	0.00e+00

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Expression of USP9X in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to USP9X

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating USP9X

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
USP9X	hsa-miR-545-3p	99.9451	NM_001039590
USP9X	hsa-miR-1297	99.5289	NM_001039590
USP9X	hsa-miR-544a	99.2844	NM_001039590
USP9X	hsa-miR-26a-5p	99.1649	NM_001039590
USP9X	hsa-miR-26b-5p	99.1649	NM_001039590
USP9X	hsa-miR-4465	98.9897	NM_001039590
USP9X	hsa-miR-3120-3p	98.1591	NM_001039590
USP9X	hsa-miR-561-3p	98.0005	NM_001039590
USP9X	hsa-miR-548an	97.4155	NM_001039590
USP9X	hsa-miR-6738-3p	97.3536	NM_001039590
USP9X	hsa-miR-455-5p	97.0969	NM_001039590
USP9X	hsa-miR-1227-3p	95.3027	NM_001039590
USP9X	hsa-miR-3613-3p	95.2507	NM_001039590
USP9X	hsa-miR-5692a	93.4979	NM_001039590
USP9X	hsa-miR-190a-3p	93.3768	NM_001039590
USP9X	hsa-miR-8063	93.1307	NM_001039590
USP9X	hsa-miR-1468-3p	92.8398	NM_001039590
USP9X	hsa-miR-4291	92.5213	NM_001039590
USP9X	hsa-miR-10523-5p	92.2474	NM_001039590
USP9X	hsa-miR-3680-3p	91.426	NM_001039590
USP9X	hsa-miR-548p	90.8744	NM_001039590
USP9X	hsa-miR-3121-3p	90.8072	NM_001039590
USP9X	hsa-miR-3118	90.3601	NM_001039590
USP9X	hsa-miR-134-5p	90.3601	NM_001039590
USP9X	hsa-miR-3158-5p	89.9214	NM_001039590
USP9X	hsa-miR-6516-5p	89.7961	NM_001039590
USP9X	hsa-miR-132-3p	89.7327	NM_001039590
USP9X	hsa-miR-212-3p	89.7327	NM_001039590
USP9X	hsa-miR-889-3p	89.6569	NM_001039590
USP9X	hsa-miR-1972	89.1062	NM_001039590
USP9X	hsa-miR-6808-5p	88.2655	NM_001039590
USP9X	hsa-miR-940	88.2655	NM_001039590
USP9X	hsa-miR-6893-5p	88.2655	NM_001039590
USP9X	hsa-miR-5697	88.147	NM_001039590
USP9X	hsa-miR-12136	87.7416	NM_001039590
USP9X	hsa-miR-520f-5p	87.5604	NM_001039590
USP9X	hsa-miR-340-5p	87.3317	NM_001039590
USP9X	hsa-miR-6797-3p	87.2504	NM_001039590
USP9X	hsa-miR-142-5p	87.1675	NM_001039590
USP9X	hsa-miR-5590-3p	87.1675	NM_001039590
USP9X	hsa-miR-616-5p	87.0186	NM_001039590
USP9X	hsa-miR-10395-5p	86.8225	NM_001039590
USP9X	hsa-miR-520h	86.7382	NM_001039590
USP9X	hsa-miR-520g-3p	86.7382	NM_001039590
USP9X	hsa-miR-320e	86.7336	NM_001039590
USP9X	hsa-miR-629-3p	86.6506	NM_001039590
USP9X	hsa-miR-1269b	86.5901	NM_001039590
USP9X	hsa-miR-1269a	86.5901	NM_001039590
USP9X	hsa-miR-4424	86.5454	NM_001039590
USP9X	hsa-miR-1205	86.532	NM_001039590

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Motifs and transcription factors (TFs) regulating USP9X

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
USP9X	transfac_pro__M04918	EGR1 (directAnnotation).
USP9X	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
USP9X	cisbp__M00249	WT1 (directAnnotation).
USP9X	cisbp__M01863	ZNF711 (inferredBy_Orthology).
USP9X	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
USP9X	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
USP9X	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
USP9X	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
USP9X	transfac_pro__M05432	ZSCAN18 (directAnnotation).
USP9X	hdpi__TIMELESS	TIMELESS (directAnnotation).
USP9X	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
USP9X	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
USP9X	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
USP9X	jaspar__MA1122.1	TFDP1 (directAnnotation).
USP9X	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
USP9X	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
USP9X	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
USP9X	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
USP9X	transfac_pro__M01175	ZBTB7B (directAnnotation).
USP9X	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
USP9X	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
USP9X	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
USP9X	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
USP9X	metacluster_3.14	WT1; WT1 (directAnnotation).
USP9X	metacluster_2.7	IRF1; IRF1; IRF2; IRF2; IRF3; IRF4; IRF5; IRF6; IRF7; IRF7; IRF8; IRF8; IRF9; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; PRDM1; STAT1; STAT1; STAT2 (directAnnotation). PRDM1; PRDM1; PRDM1 (inferredBy_Orthology).
USP9X	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
USP9X	metacluster_14.20	TFEB (directAnnotation).
USP9X	nitta__nau_TAGGTG20NTGT_KG_NNGTCAGCTGACNN_m1_c3	MYF5; MYF6; MYOD1; MYOG (inferredBy_Orthology).
USP9X	cisbp__M01725	SREBF2 (inferredBy_Orthology).
USP9X	metacluster_57.2	BACH1; MITF; MITF; TFE3; TFE3; TFE3; TFEB; USF2 (directAnnotation). MITF; TFE3; USF1; USF2 (inferredBy_Orthology).
USP9X	metacluster_22.28	BACH1 (directAnnotation).
USP9X	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
USP9X	transfac_pro__M06601	ZNF501 (directAnnotation).
USP9X	metacluster_14.23	TFE3 (directAnnotation).
USP9X	transfac_pro__M06111	ZNF254 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."