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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UCHL5

Summary for UCHL5

Gene information	Gene symbol	UCHL5
	Ensembl ID	ENSG00000116750
	Entrez ID	51377
	Gene name	ubiquitin C-terminal hydrolase L5
	Synonyms	CGI-70\|INO80R\|UCH37
	Gene type	protein_coding
	UniProtAcc	Q9Y5K5

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Dataset with differentially expressed gene: UCHL5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-0.767481	1.77e-04
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.58123	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.275326	9.87e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.354201	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.268322	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.330827	1.29e-19
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.318709	5.05e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.263444	8.83e-09
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.676688	0.00e+00

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Expression of UCHL5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UCHL5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UCHL5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UCHL5	hsa-miR-3163	98.5328	NM_001199261
UCHL5	hsa-miR-5581-3p	97.0963	NM_001199261
UCHL5	hsa-miR-450b-5p	96.3165	NM_001199262
UCHL5	hsa-miR-548c-3p	93.64	NM_001199261
UCHL5	hsa-miR-3658	93.2718	NM_001199263
UCHL5	hsa-miR-4328	93.119	NM_001199261
UCHL5	hsa-miR-4282	93.0874	NM_001199261
UCHL5	hsa-miR-5001-3p	92.7397	NM_001199261
UCHL5	hsa-miR-224-5p	92.1386	NM_001199261
UCHL5	hsa-miR-1-5p	91.3151	NM_001199261
UCHL5	hsa-miR-7844-5p	90.5812	NM_001199263
UCHL5	hsa-miR-889-3p	90.5027	NM_001199261
UCHL5	hsa-miR-5696	89.8025	NM_001199261
UCHL5	hsa-miR-92b-3p	89.3727	NM_001199261
UCHL5	hsa-miR-92a-3p	89.3727	NM_001199261
UCHL5	hsa-miR-32-5p	89.3727	NM_001199261
UCHL5	hsa-miR-5692a	88.9479	NM_001199261
UCHL5	hsa-miR-582-3p	88.3692	NM_001199261
UCHL5	hsa-miR-8485	88.2568	NM_001199261
UCHL5	hsa-miR-590-3p	87.145	NM_001199263
UCHL5	hsa-miR-150-3p	86.7289	NM_001199263
UCHL5	hsa-miR-381-3p	86.4914	NM_001199263
UCHL5	hsa-miR-300	86.4914	NM_001199263
UCHL5	hsa-miR-4633-5p	85.6743	NM_001199261
UCHL5	hsa-miR-342-3p	85.5515	NM_001199263
UCHL5	hsa-miR-25-3p	84.9469	NM_001199261
UCHL5	hsa-miR-363-3p	84.9469	NM_001199261
UCHL5	hsa-miR-367-3p	84.9469	NM_001199261
UCHL5	hsa-miR-21-3p	83.3642	NM_001199261
UCHL5	hsa-miR-122b-3p	83.3642	NM_001199261
UCHL5	hsa-miR-28-3p	82.9612	NM_001199263
UCHL5	hsa-miR-1253	81.2057	NM_001199261
UCHL5	hsa-miR-3177-5p	81.0384	NM_001199261
UCHL5	hsa-miR-4446-5p	80.9004	NM_001199261
UCHL5	hsa-miR-551b-5p	80.5083	NM_001199261
UCHL5	hsa-miR-6504-3p	80.4531	NM_001199261
UCHL5	hsa-miR-10399-5p	80.4531	NM_001199261
UCHL5	hsa-miR-4635	80.2193	NM_001199261

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Motifs and transcription factors (TFs) regulating UCHL5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UCHL5	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UCHL5	transfac_pro__M03806	ZBTB7C (directAnnotation).
UCHL5	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UCHL5	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
UCHL5	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
UCHL5	metacluster_182.10	ZFX (directAnnotation).
UCHL5	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
UCHL5	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
UCHL5	cisbp__M08198	ELF1 (directAnnotation).
UCHL5	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
UCHL5	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
UCHL5	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
UCHL5	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
UCHL5	jaspar__MA1708.1	ETV7 (directAnnotation).
UCHL5	hdpi__ELF2	ELF2 (directAnnotation).
UCHL5	swissregulon__hs__ELK1	ELK1 (directAnnotation).
UCHL5	metacluster_183.4	ETS1 (inferredBy_Orthology).
UCHL5	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
UCHL5	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
UCHL5	jaspar__MA1932.1	HOXB13 (directAnnotation).
UCHL5	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
UCHL5	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).
UCHL5	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
UCHL5	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."