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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBR5

Summary for UBR5

Gene information	Gene symbol	UBR5
	Ensembl ID	ENSG00000104517
	Entrez ID	51366
	Gene name	ubiquitin protein ligase E3 component n-recognin 5
	Synonyms	DD5\|EDD\|EDD1\|HYD\|KIAA0896
	Gene type	protein_coding
	UniProtAcc	O95071

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Dataset with differentially expressed gene: UBR5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.307891	3.01e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.261129	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.760824	0.00e+00

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Expression of UBR5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBR5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
UBR5	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating UBR5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBR5	hsa-miR-3941	99.2769	NM_015902
UBR5	hsa-miR-12136	98.4183	NM_015902
UBR5	hsa-miR-4672	97.8291	NM_015902
UBR5	hsa-miR-548az-5p	97.4734	NM_015902
UBR5	hsa-miR-548t-5p	97.4734	NM_015902
UBR5	hsa-miR-548p	97.1748	NM_015902
UBR5	hsa-miR-3662	97.1537	NM_015902
UBR5	hsa-miR-216a-3p	96.9361	NM_015902
UBR5	hsa-miR-128-3p	96.9361	NM_015902
UBR5	hsa-miR-7156-5p	96.3418	NM_015902
UBR5	hsa-miR-4273	96.1507	NM_015902
UBR5	hsa-miR-3681-3p	96.1269	NM_015902
UBR5	hsa-miR-1283	96.0816	NM_015902
UBR5	hsa-miR-1468-3p	95.4346	NM_015902
UBR5	hsa-let-7c-3p	95.417	NM_015902
UBR5	hsa-miR-449c-3p	94.8077	NM_015902
UBR5	hsa-miR-589-3p	94.7953	NM_015902
UBR5	hsa-miR-3182	94.5277	NM_015902
UBR5	hsa-miR-223-3p	94.5126	NM_015902
UBR5	hsa-miR-642a-5p	93.0107	NM_015902
UBR5	hsa-miR-545-3p	92.8459	NM_015902
UBR5	hsa-miR-548c-3p	92.0857	NM_015902
UBR5	hsa-miR-153-5p	91.4604	NM_015902
UBR5	hsa-miR-466	90.7514	NM_015902
UBR5	hsa-miR-548n	90.6751	NM_015902
UBR5	hsa-miR-4659b-3p	90.587	NM_015902
UBR5	hsa-miR-4659a-3p	90.587	NM_015902
UBR5	hsa-miR-7-5p	90.2012	NM_015902
UBR5	hsa-miR-371b-3p	89.5471	NM_015902
UBR5	hsa-miR-524-5p	89.3535	NM_015902
UBR5	hsa-miR-520d-5p	89.3535	NM_015902
UBR5	hsa-miR-140-5p	88.5668	NM_015902
UBR5	hsa-miR-6842-3p	87.9146	NM_015902
UBR5	hsa-miR-548aj-3p	87.5621	NM_015902
UBR5	hsa-miR-548x-3p	87.5621	NM_015902
UBR5	hsa-miR-2277-3p	87.2765	NM_015902
UBR5	hsa-miR-548d-3p	87.2125	NM_015902
UBR5	hsa-miR-30d-3p	86.6025	NM_015902
UBR5	hsa-miR-30a-3p	86.6025	NM_015902
UBR5	hsa-miR-30e-3p	86.6025	NM_015902
UBR5	hsa-miR-3714	85.5573	NM_015902
UBR5	hsa-miR-12129	85.4067	NM_015902
UBR5	hsa-miR-548bb-3p	85.2942	NM_015902
UBR5	hsa-miR-6513-5p	85.2141	NM_015902
UBR5	hsa-miR-4666a-5p	84.6943	NM_015902
UBR5	hsa-miR-3938	84.6657	NM_015902
UBR5	hsa-miR-5689	83.6978	NM_015902
UBR5	hsa-miR-27b-3p	83.6414	NM_015902
UBR5	hsa-miR-27a-3p	83.6414	NM_015902
UBR5	hsa-miR-9985	83.6414	NM_015902

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Motifs and transcription factors (TFs) regulating UBR5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBR5	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
UBR5	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
UBR5	transfac_pro__M01253	CNOT3 (directAnnotation).
UBR5	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
UBR5	metacluster_3.10	KLF2; KLF4 (directAnnotation).
UBR5	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
UBR5	jaspar__MA1721.1	ZNF93 (directAnnotation).
UBR5	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
UBR5	swissregulon__hs__CHD1	CHD1 (directAnnotation).
UBR5	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
UBR5	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
UBR5	jaspar__MA1122.1	TFDP1 (directAnnotation).
UBR5	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
UBR5	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
UBR5	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
UBR5	tfdimers__MD00151	CHURC1 (directAnnotation).
UBR5	tfdimers__MD00391	KLF4 (directAnnotation).
UBR5	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
UBR5	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
UBR5	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
UBR5	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
UBR5	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
UBR5	transfac_pro__M01973	PLAG1 (directAnnotation).
UBR5	transfac_pro__M12697	ZNF142 (directAnnotation).
UBR5	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
UBR5	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBR5	jaspar__MA0748.2	YY2 (directAnnotation).
UBR5	transfac_pro__M01303	SP1 (directAnnotation).
UBR5	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
UBR5	metacluster_3.14	WT1; WT1 (directAnnotation).
UBR5	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
UBR5	transfac_public__M00491	PATZ1 (directAnnotation).
UBR5	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
UBR5	transfac_pro__M07397	ZNF148 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."