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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBL3

Summary for UBL3

Gene information	Gene symbol	UBL3
	Ensembl ID	ENSG00000122042
	Entrez ID	5412
	Gene name	ubiquitin like 3
	Synonyms	DKFZP434K151\|FLJ32018\|HCG-1\|PNSC1
	Gene type	protein_coding
	UniProtAcc	O95164

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Dataset with differentially expressed gene: UBL3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.330648	9.28e-13
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.335983	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.649016	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.03316	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.281027	0.00e+00

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Expression of UBL3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBL3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBL3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBL3	hsa-miR-335-3p	96.5381	NM_007106
UBL3	hsa-miR-584-3p	96.5114	NM_007106
UBL3	hsa-miR-3065-5p	96.0569	NM_007106
UBL3	hsa-miR-3688-3p	95.3593	NM_007106
UBL3	hsa-miR-4473	95.2413	NM_007106
UBL3	hsa-miR-4678	94.8701	NM_007106
UBL3	hsa-miR-7151-3p	93.8777	NM_007106
UBL3	hsa-miR-4635	93.7183	NM_007106
UBL3	hsa-miR-548ap-3p	93.3542	NM_007106
UBL3	hsa-miR-548aa	93.3542	NM_007106
UBL3	hsa-miR-548t-3p	93.3542	NM_007106
UBL3	hsa-miR-3911	93.094	NM_007106
UBL3	hsa-miR-153-5p	92.791	NM_007106
UBL3	hsa-miR-330-3p	92.1507	NM_007106
UBL3	hsa-miR-6071	91.7041	NM_007106
UBL3	hsa-miR-664b-3p	91.6827	NM_007106
UBL3	hsa-miR-579-3p	91.6827	NM_007106
UBL3	hsa-miR-8076	91.4834	NM_007106
UBL3	hsa-miR-3192-3p	91.3606	NM_007106
UBL3	hsa-miR-7160-5p	91.1265	NM_007106
UBL3	hsa-miR-300	90.4774	NM_007106
UBL3	hsa-miR-381-3p	90.4774	NM_007106
UBL3	hsa-miR-331-5p	90.3082	NM_007106
UBL3	hsa-miR-217-5p	90.0942	NM_007106
UBL3	hsa-miR-1284	89.7969	NM_007106
UBL3	hsa-miR-30e-3p	89.7234	NM_007106
UBL3	hsa-miR-30d-3p	89.7234	NM_007106
UBL3	hsa-miR-30a-3p	89.7234	NM_007106
UBL3	hsa-miR-4269	88.9862	NM_007106
UBL3	hsa-miR-6715b-5p	88.9862	NM_007106
UBL3	hsa-miR-6807-3p	88.7483	NM_007106
UBL3	hsa-miR-6509-5p	88.6887	NM_007106
UBL3	hsa-miR-651-3p	88.5457	NM_007106
UBL3	hsa-miR-331-3p	88.2519	NM_007106
UBL3	hsa-miR-548c-3p	88.2193	NM_007106
UBL3	hsa-miR-5696	87.9292	NM_007106
UBL3	hsa-miR-944	87.7846	NM_007106
UBL3	hsa-miR-6876-3p	87.6703	NM_007106
UBL3	hsa-miR-626	87.6703	NM_007106
UBL3	hsa-miR-19b-3p	87.5961	NM_007106
UBL3	hsa-miR-19a-3p	87.5961	NM_007106
UBL3	hsa-miR-340-5p	87.1624	NM_007106
UBL3	hsa-miR-122b-5p	86.9811	NM_007106
UBL3	hsa-miR-302d-5p	86.8778	NM_007106
UBL3	hsa-miR-302b-5p	86.8778	NM_007106
UBL3	hsa-miR-3646	86.8416	NM_007106
UBL3	hsa-miR-4422	86.4215	NM_007106
UBL3	hsa-miR-759	86.388	NM_007106
UBL3	hsa-miR-6889-3p	84.8944	NM_007106
UBL3	hsa-miR-3148	84.8394	NM_007106

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Motifs and transcription factors (TFs) regulating UBL3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBL3	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBL3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."