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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2V2

Summary for UBE2V2

Gene information	Gene symbol	UBE2V2
	Ensembl ID	ENSG00000169139
	Entrez ID	7336
	Gene name	ubiquitin conjugating enzyme E2 V2
	Synonyms	DDVit-1\|DDVIT1\|EDAF-1\|EDPF-1\|EDPF1\|MMS2\|UEV-2\|UEV2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: UBE2V2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.54645	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.65288	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.365177	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.316908	3.05e-22
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.317605	7.80e-13
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.558431	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.492308	5.99e-31
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.403668	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.710545	0.00e+00
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.271799	0.00e+00

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Expression of UBE2V2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2V2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2V2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2V2	hsa-miR-499a-5p	98.2056	NM_003350
UBE2V2	hsa-miR-223-5p	97.166	NM_003350
UBE2V2	hsa-miR-3658	96.6449	NM_003350
UBE2V2	hsa-miR-493-5p	95.7909	NM_003350
UBE2V2	hsa-miR-4795-3p	95.3114	NM_003350
UBE2V2	hsa-miR-30d-5p	95.0453	NM_003350
UBE2V2	hsa-miR-30e-5p	95.0453	NM_003350
UBE2V2	hsa-miR-30b-5p	95.0453	NM_003350
UBE2V2	hsa-miR-30c-5p	95.0453	NM_003350
UBE2V2	hsa-miR-30a-5p	95.0453	NM_003350
UBE2V2	hsa-miR-3977	94.34	NM_003350
UBE2V2	hsa-miR-3617-5p	94.1167	NM_003350
UBE2V2	hsa-miR-641	94.1167	NM_003350
UBE2V2	hsa-miR-4803	94.0574	NM_003350
UBE2V2	hsa-miR-5011-3p	93.7281	NM_003350
UBE2V2	hsa-miR-208a-3p	93.6872	NM_003350
UBE2V2	hsa-miR-208b-3p	93.6872	NM_003350
UBE2V2	hsa-miR-371b-5p	91.7438	NM_003350
UBE2V2	hsa-miR-616-5p	91.7438	NM_003350
UBE2V2	hsa-miR-373-5p	91.7438	NM_003350
UBE2V2	hsa-miR-511-3p	91.3018	NM_003350
UBE2V2	hsa-miR-6869-5p	90.9946	NM_003350
UBE2V2	hsa-miR-3689b-5p	90.699	NM_003350
UBE2V2	hsa-miR-3689e	90.699	NM_003350
UBE2V2	hsa-miR-3689a-5p	90.699	NM_003350
UBE2V2	hsa-miR-3689f	90.699	NM_003350
UBE2V2	hsa-miR-7-2-3p	90.2267	NM_003350
UBE2V2	hsa-miR-7-1-3p	90.2267	NM_003350
UBE2V2	hsa-miR-4699-3p	90.0717	NM_003350
UBE2V2	hsa-miR-340-5p	89.6573	NM_003350
UBE2V2	hsa-miR-3145-3p	89.1212	NM_003350
UBE2V2	hsa-miR-8063	88.3484	NM_003350
UBE2V2	hsa-miR-3140-5p	88.1288	NM_003350
UBE2V2	hsa-miR-8066	87.2916	NM_003350
UBE2V2	hsa-miR-4660	87.238	NM_003350
UBE2V2	hsa-miR-570-3p	86.6927	NM_003350
UBE2V2	hsa-miR-130b-5p	86.6608	NM_003350
UBE2V2	hsa-miR-526b-5p	86.1709	NM_003350
UBE2V2	hsa-miR-4666a-5p	85.7257	NM_003350
UBE2V2	hsa-miR-216a-5p	84.949	NM_003350
UBE2V2	hsa-miR-3680-3p	84.8821	NM_003350
UBE2V2	hsa-miR-6730-3p	84.7176	NM_003350
UBE2V2	hsa-miR-5680	83.3087	NM_003350
UBE2V2	hsa-miR-888-5p	82.8173	NM_003350
UBE2V2	hsa-miR-10393-5p	81.4157	NM_003350

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Motifs and transcription factors (TFs) regulating UBE2V2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2V2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBE2V2	metacluster_151.2	ZNF23 (directAnnotation).
UBE2V2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2V2	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBE2V2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2V2	taipale__ELK1_full_NACTTCCGSCGGAARMN_repr	ELK1 (directAnnotation).
UBE2V2	homer__NCCACGTG_c-Myc	MYC (directAnnotation).
UBE2V2	transfac_pro__M04748	GABPA (directAnnotation).
UBE2V2	taipale_tf_pairs__ETV2_FOXI1_RNCGGAANNAAACA_CAP_repr	ETV2; FOXI1 (directAnnotation).
UBE2V2	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
UBE2V2	hdpi__ELF2	ELF2 (directAnnotation).
UBE2V2	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
UBE2V2	metacluster_81.7	CREB1 (directAnnotation).
UBE2V2	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
UBE2V2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."