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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2N

Summary for UBE2N

Gene information	Gene symbol	UBE2N
	Ensembl ID	ENSG00000177889
	Entrez ID	7334
	Gene name	ubiquitin conjugating enzyme E2 N
	Synonyms	MGC8489\|UBC13\|UbcH-ben
	Gene type	protein_coding
	UniProtAcc	P61088

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Dataset with differentially expressed gene: UBE2N

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.447945	2.46e-34
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.574688	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.251587	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.828567	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.361623	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	CD8+ T cells	-0.281357	2.34e-02
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.4532	2.76e-43
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.426181	3.95e-24
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.739949	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.63739	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.968861	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.498837	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.324116	0.00e+00

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Expression of UBE2N in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2N

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2N

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2N	hsa-miR-3163	99.9858	NM_003348
UBE2N	hsa-miR-767-3p	98.2029	NM_003348
UBE2N	hsa-miR-590-3p	95.2206	NM_003348
UBE2N	hsa-miR-5000-3p	94.8698	NM_003348
UBE2N	hsa-miR-625-5p	92.9027	NM_003348
UBE2N	hsa-miR-3912-5p	92.8862	NM_003348
UBE2N	hsa-miR-6828-3p	92.6144	NM_003348
UBE2N	hsa-miR-4436a	92.0539	NM_003348
UBE2N	hsa-miR-216a-3p	89.3654	NM_003348
UBE2N	hsa-miR-128-3p	89.3654	NM_003348
UBE2N	hsa-miR-8064	89.2662	NM_003348
UBE2N	hsa-miR-6847-3p	89.2297	NM_003348
UBE2N	hsa-miR-3143	88.1902	NM_003348
UBE2N	hsa-miR-3681-3p	87.6523	NM_003348
UBE2N	hsa-miR-548b-3p	87.1675	NM_003348
UBE2N	hsa-miR-186-5p	86.9374	NM_003348
UBE2N	hsa-miR-4778-5p	86.6254	NM_003348
UBE2N	hsa-miR-208a-5p	86.1734	NM_003348
UBE2N	hsa-miR-208b-5p	86.1734	NM_003348
UBE2N	hsa-miR-633	85.8299	NM_003348
UBE2N	hsa-miR-7150	85.3106	NM_003348
UBE2N	hsa-miR-4729	84.1829	NM_003348
UBE2N	hsa-miR-34b-3p	84.1477	NM_003348
UBE2N	hsa-miR-3149	83.866	NM_003348
UBE2N	hsa-miR-33a-3p	83.8347	NM_003348
UBE2N	hsa-miR-8068	83.2202	NM_003348
UBE2N	hsa-miR-508-5p	82.319	NM_003348
UBE2N	hsa-miR-885-5p	81.9109	NM_003348
UBE2N	hsa-miR-4768-3p	80.9372	NM_003348
UBE2N	hsa-miR-27b-3p	80.8796	NM_003348
UBE2N	hsa-miR-9985	80.8796	NM_003348
UBE2N	hsa-miR-27a-3p	80.8796	NM_003348
UBE2N	hsa-miR-378g	80.5165	NM_003348
UBE2N	hsa-miR-3140-3p	80.0944	NM_003348

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Motifs and transcription factors (TFs) regulating UBE2N

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2N	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
UBE2N	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
UBE2N	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
UBE2N	taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP	ETV2; FOXI1 (directAnnotation).
UBE2N	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
UBE2N	metacluster_135.11	NR2C2 (directAnnotation).
UBE2N	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBE2N	tfdimers__MD00038	TFAP2C (directAnnotation).
UBE2N	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBE2N	metacluster_7.13	ZFX (directAnnotation).
UBE2N	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
UBE2N	cisbp__M00968	MTF2 (directAnnotation).
UBE2N	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBE2N	metacluster_160.20	JUND; PRDM15 (directAnnotation).
UBE2N	cisbp__M00341	PAX6 (directAnnotation).
UBE2N	metacluster_198.3	ZFP64 (directAnnotation).
UBE2N	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
UBE2N	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBE2N	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBE2N	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBE2N	cisbp__M00788	ZFY (inferredBy_Orthology).
UBE2N	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UBE2N	metacluster_175.1	ZNF283 (directAnnotation).
UBE2N	hdpi__ZNF304	ZNF304 (directAnnotation).
UBE2N	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBE2N	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UBE2N	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBE2N	transfac_pro__M01199	TRIM28 (directAnnotation).
UBE2N	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBE2N	metacluster_151.2	ZNF23 (directAnnotation).
UBE2N	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2N	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBE2N	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBE2N	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2N	hdpi__TP73	TP73 (directAnnotation).
UBE2N	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
UBE2N	taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAP	ETV1; FOXO1 (directAnnotation).
UBE2N	jaspar__MA0748.2	YY2 (directAnnotation).
UBE2N	transfac_pro__M01298	MECP2 (directAnnotation).
UBE2N	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
UBE2N	metacluster_182.10	ZFX (directAnnotation).
UBE2N	transfac_pro__M00492	STAT1 (directAnnotation).
UBE2N	tfdimers__MD00066	ELF1 (directAnnotation).
UBE2N	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
UBE2N	homer__ACAGGATGTGGT_ETS_RUNX	RUNX1 (directAnnotation).
UBE2N	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
UBE2N	cisbp__M00249	WT1 (directAnnotation).
UBE2N	transfac_pro__M01122	ZNF219 (directAnnotation).
UBE2N	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
UBE2N	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."