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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2E3

Summary for UBE2E3

Gene information	Gene symbol	UBE2E3
	Ensembl ID	ENSG00000170035
	Entrez ID	10477
	Gene name	ubiquitin conjugating enzyme E2 E3
	Synonyms	UbcH9
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: UBE2E3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.413433	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-2.34305	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.648815	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.399509	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.293331	1.60e-08
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.357301	6.09e-15
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.322756	1.11e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.426207	1.92e-24
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.798083	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.330577	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.256131	0.00e+00

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Expression of UBE2E3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2E3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2E3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2E3	hsa-miR-548ba	98.4264	NM_006357
UBE2E3	hsa-miR-548ai	98.09	NM_006357
UBE2E3	hsa-miR-548ag	98.09	NM_006357
UBE2E3	hsa-miR-570-5p	98.09	NM_006357
UBE2E3	hsa-miR-888-3p	96.3362	NM_001278554
UBE2E3	hsa-miR-499b-3p	95.2971	NM_006357
UBE2E3	hsa-miR-499a-3p	95.2971	NM_006357
UBE2E3	hsa-miR-187-5p	94.9003	NM_001278554
UBE2E3	hsa-miR-5690	93.8081	NM_006357
UBE2E3	hsa-miR-4803	93.788	NM_001278554
UBE2E3	hsa-miR-548m	91.9743	NM_006357
UBE2E3	hsa-miR-4733-5p	91.4775	NM_006357
UBE2E3	hsa-miR-524-5p	90.3617	NM_001278554
UBE2E3	hsa-miR-520d-5p	90.3617	NM_001278554
UBE2E3	hsa-miR-374c-5p	89.9993	NM_006357
UBE2E3	hsa-miR-655-3p	89.9993	NM_006357
UBE2E3	hsa-miR-139-5p	89.6277	NM_006357
UBE2E3	hsa-miR-5701	89.4571	NM_001278554
UBE2E3	hsa-miR-610	88.6266	NM_001278554
UBE2E3	hsa-miR-5689	88.6159	NM_006357
UBE2E3	hsa-miR-629-5p	87.4088	NM_006357
UBE2E3	hsa-miR-4303	86.4741	NM_001278554
UBE2E3	hsa-miR-5003-5p	86.2957	NM_006357
UBE2E3	hsa-miR-379-5p	86.1656	NM_006357
UBE2E3	hsa-miR-4297	85.841	NM_006357
UBE2E3	hsa-miR-6768-3p	85.8345	NM_001278554
UBE2E3	hsa-miR-4484	85.8345	NM_001278554
UBE2E3	hsa-miR-548an	85.8345	NM_001278554
UBE2E3	hsa-miR-4433a-3p	84.8881	NM_006357
UBE2E3	hsa-miR-4768-3p	84.8881	NM_006357
UBE2E3	hsa-miR-3529-5p	84.5417	NM_006357
UBE2E3	hsa-miR-4653-5p	84.1619	NM_001278554
UBE2E3	hsa-miR-3921	84.1619	NM_001278554
UBE2E3	hsa-miR-5002-5p	83.415	NM_006357
UBE2E3	hsa-miR-186-3p	83.3717	NM_006357
UBE2E3	hsa-miR-5692c	83.1148	NM_006357
UBE2E3	hsa-miR-5692b	83.1148	NM_006357
UBE2E3	hsa-miR-1298-3p	82.883	NM_001278554
UBE2E3	hsa-miR-4770	82.8452	NM_006357
UBE2E3	hsa-miR-143-3p	82.8452	NM_006357
UBE2E3	hsa-miR-548e-5p	82.753	NM_006357
UBE2E3	hsa-miR-4724-3p	82.6169	NM_001278554
UBE2E3	hsa-miR-16-1-3p	80.0875	NM_006357

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Motifs and transcription factors (TFs) regulating UBE2E3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2E3	transfac_public__M00491	PATZ1 (directAnnotation).
UBE2E3	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
UBE2E3	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
UBE2E3	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
UBE2E3	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
UBE2E3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
UBE2E3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
UBE2E3	transfac_pro__M04950	EGR1 (directAnnotation).
UBE2E3	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
UBE2E3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
UBE2E3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
UBE2E3	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
UBE2E3	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
UBE2E3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
UBE2E3	transfac_pro__M00652	NRF1 (directAnnotation).
UBE2E3	hdpi__ETV4	ETV4 (directAnnotation).
UBE2E3	transfac_pro__M04866	HDAC2 (directAnnotation).
UBE2E3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
UBE2E3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
UBE2E3	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
UBE2E3	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
UBE2E3	metacluster_135.11	NR2C2 (directAnnotation).
UBE2E3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
UBE2E3	tfdimers__MD00038	TFAP2C (directAnnotation).
UBE2E3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
UBE2E3	cisbp__M00968	MTF2 (directAnnotation).
UBE2E3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
UBE2E3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
UBE2E3	cisbp__M00341	PAX6 (directAnnotation).
UBE2E3	metacluster_198.3	ZFP64 (directAnnotation).
UBE2E3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBE2E3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBE2E3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBE2E3	cisbp__M00788	ZFY (inferredBy_Orthology).
UBE2E3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
UBE2E3	metacluster_175.1	ZNF283 (directAnnotation).
UBE2E3	hdpi__ZNF304	ZNF304 (directAnnotation).
UBE2E3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBE2E3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UBE2E3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBE2E3	transfac_pro__M01199	TRIM28 (directAnnotation).
UBE2E3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBE2E3	metacluster_151.2	ZNF23 (directAnnotation).
UBE2E3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2E3	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBE2E3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2E3	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
UBE2E3	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
UBE2E3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
UBE2E3	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."