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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: UBE2D3

Summary for UBE2D3

Gene information	Gene symbol	UBE2D3
	Ensembl ID	ENSG00000109332
	Entrez ID	7323
	Gene name	ubiquitin conjugating enzyme E2 D3
	Synonyms	UbcH5C
	Gene type	protein_coding
	UniProtAcc	P61077

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Dataset with differentially expressed gene: UBE2D3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.35475	1.15e-20
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.274426	4.62e-40
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.327449	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.256529	4.73e-09
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	CD8+ T cells	0.252265	5.32e-44
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.395315	3.06e-42
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.292234	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.28122	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.315388	1.33e-11
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.412515	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.403821	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.617968	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.458162	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.332913	7.72e-14
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.403088	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.382593	1.06e-28
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.633406	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.42716	2.08e-36
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.419619	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-1.49375	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.593846	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.522738	0.00e+00

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Expression of UBE2D3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2D3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2D3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2D3	hsa-miR-3613-3p	99.8697	NM_181886
UBE2D3	hsa-miR-551b-5p	99.4973	NM_181886
UBE2D3	hsa-miR-152-3p	99.4174	NM_181892
UBE2D3	hsa-miR-148a-3p	99.4174	NM_181892
UBE2D3	hsa-miR-148b-3p	99.4174	NM_181892
UBE2D3	hsa-miR-491-3p	98.7751	NM_181886
UBE2D3	hsa-miR-4422	97.6637	NM_181892
UBE2D3	hsa-miR-3646	97.422	NM_181886
UBE2D3	hsa-miR-3163	96.7881	NM_181892
UBE2D3	hsa-miR-4698	96.4638	NM_181892
UBE2D3	hsa-miR-4519	95.6171	NM_181892
UBE2D3	hsa-miR-4729	95.5281	NM_181886
UBE2D3	hsa-miR-33a-3p	95.2119	NM_181892
UBE2D3	hsa-miR-524-5p	94.7353	NM_181892
UBE2D3	hsa-miR-520d-5p	94.7353	NM_181892
UBE2D3	hsa-miR-549a-3p	94.4564	NM_181886
UBE2D3	hsa-miR-4701-5p	94.3537	NM_181886
UBE2D3	hsa-miR-588	94.3537	NM_181886
UBE2D3	hsa-miR-942-3p	94.11	NM_181892
UBE2D3	hsa-miR-4262	93.9378	NM_181892
UBE2D3	hsa-miR-181d-5p	93.9378	NM_181892
UBE2D3	hsa-miR-4328	93.0238	NM_181886
UBE2D3	hsa-miR-513c-3p	92.6497	NM_181886
UBE2D3	hsa-miR-513a-3p	92.6497	NM_181886
UBE2D3	hsa-miR-5688	92.4991	NM_181886
UBE2D3	hsa-miR-21-5p	92.3881	NM_181892
UBE2D3	hsa-miR-495-3p	92.3707	NM_181886
UBE2D3	hsa-miR-1257	91.8998	NM_181886
UBE2D3	hsa-miR-203a-3p	91.6589	NM_181892
UBE2D3	hsa-miR-12136	91.6027	NM_181892
UBE2D3	hsa-miR-181a-5p	91.5523	NM_181892
UBE2D3	hsa-miR-181c-5p	91.5523	NM_181892
UBE2D3	hsa-miR-181b-5p	91.5523	NM_181892
UBE2D3	hsa-miR-5701	91.4639	NM_181892
UBE2D3	hsa-miR-590-5p	91.4023	NM_181892
UBE2D3	hsa-miR-3606-3p	91.1913	NM_181886
UBE2D3	hsa-miR-367-5p	90.9204	NM_181886
UBE2D3	hsa-miR-3944-5p	90.064	NM_181886
UBE2D3	hsa-miR-1264	89.9933	NM_181892
UBE2D3	hsa-miR-12123	89.9912	NM_181892
UBE2D3	hsa-miR-586	89.7006	NM_181886
UBE2D3	hsa-miR-6765-3p	89.6483	NM_181892
UBE2D3	hsa-miR-6882-5p	89.5512	NM_181892
UBE2D3	hsa-miR-2278	89.5101	NM_181886
UBE2D3	hsa-miR-6505-5p	89.4851	NM_181892
UBE2D3	hsa-miR-1245b-3p	89.4642	NM_181886
UBE2D3	hsa-miR-7159-5p	89.3555	NM_181886
UBE2D3	hsa-miR-889-5p	89.3181	NM_181892
UBE2D3	hsa-miR-548az-5p	88.8618	NM_181892
UBE2D3	hsa-miR-548t-5p	88.8618	NM_181892

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Motifs and transcription factors (TFs) regulating UBE2D3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2D3	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
UBE2D3	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
UBE2D3	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
UBE2D3	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
UBE2D3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
UBE2D3	transfac_pro__M06331	ZNF343 (directAnnotation).
UBE2D3	metacluster_135.11	NR2C2 (directAnnotation).
UBE2D3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
UBE2D3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
UBE2D3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
UBE2D3	cisbp__M00788	ZFY (inferredBy_Orthology).
UBE2D3	hdpi__ZNF304	ZNF304 (directAnnotation).
UBE2D3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
UBE2D3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
UBE2D3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
UBE2D3	transfac_pro__M01199	TRIM28 (directAnnotation).
UBE2D3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
UBE2D3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2D3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
UBE2D3	transfac_pro__M03806	ZBTB7C (directAnnotation).
UBE2D3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
UBE2D3	metacluster_33.8	BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
UBE2D3	metacluster_182.10	ZFX (directAnnotation).
UBE2D3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
UBE2D3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
UBE2D3	transfac_pro__M00430	E2F1 (directAnnotation).
UBE2D3	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
UBE2D3	transfac_pro__M04893	TAF1 (directAnnotation).
UBE2D3	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
UBE2D3	hdpi__HIP2	UBE2K (directAnnotation).
UBE2D3	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
UBE2D3	hdpi__TIMELESS	TIMELESS (directAnnotation).
UBE2D3	metacluster_191.5	SPDEF (inferredBy_Orthology).
UBE2D3	transfac_pro__M00938	E2F1 (directAnnotation).
UBE2D3	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
UBE2D3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
UBE2D3	hdpi__RARA	RARA (directAnnotation).
UBE2D3	hdpi__ELF2	ELF2 (directAnnotation).
UBE2D3	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
UBE2D3	jaspar__MA1583.1	ZFP57 (directAnnotation).
UBE2D3	transfac_pro__M02898	SMAD3 (directAnnotation).
UBE2D3	hdpi__HTATIP2	HTATIP2 (directAnnotation).
UBE2D3	transfac_pro__M04916	TAF1 (directAnnotation).
UBE2D3	transfac_pro__M07310	SP5 (directAnnotation).
UBE2D3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
UBE2D3	jaspar__MA1721.1	ZNF93 (directAnnotation).
UBE2D3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
UBE2D3	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
UBE2D3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
UBE2D3	swissregulon__hs__CHD1	CHD1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."