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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: UBE2D2

Summary for UBE2D2

Gene information	Gene symbol	UBE2D2
	Ensembl ID	ENSG00000131508
	Entrez ID	7322
	Gene name	ubiquitin conjugating enzyme E2 D2
	Synonyms	UBC4\|UbcH5B
	Gene type	protein_coding
	UniProtAcc	P62837

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Dataset with differentially expressed gene: UBE2D2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.406735	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	0.282824	8.41e-41
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.267991	5.44e-03
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.379329	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.322709	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.857981	1.41e-02
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	Malignant cells	-0.324635	1.76e-14
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	Malignant cells	-0.335756	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.478062	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.551168	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.756237	0.00e+00
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.473853	6.71e-42
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.434894	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.284298	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.953075	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.717085	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.495363	0.00e+00

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Expression of UBE2D2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to UBE2D2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating UBE2D2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
UBE2D2	hsa-miR-1228-3p	97.5876	NM_003339
UBE2D2	hsa-miR-3973	96.8236	NM_003339
UBE2D2	hsa-miR-342-3p	96.0509	NM_003339
UBE2D2	hsa-miR-19b-3p	95.6879	NM_003339
UBE2D2	hsa-miR-19a-3p	95.6879	NM_003339
UBE2D2	hsa-miR-518a-5p	95.5651	NM_003339
UBE2D2	hsa-miR-527	95.5651	NM_003339
UBE2D2	hsa-miR-4436b-5p	95.4562	NM_003339
UBE2D2	hsa-miR-101-3p	94.6193	NM_003339
UBE2D2	hsa-miR-4671-3p	93.6756	NM_003339
UBE2D2	hsa-miR-4672	93.5558	NM_003339
UBE2D2	hsa-miR-3688-3p	93.2311	NM_003339
UBE2D2	hsa-miR-454-3p	93.2289	NM_003339
UBE2D2	hsa-miR-4674	93.1214	NM_003339
UBE2D2	hsa-miR-10400-3p	93.1214	NM_003339
UBE2D2	hsa-miR-4437	93.0073	NM_003339
UBE2D2	hsa-miR-377-3p	93.0066	NM_003339
UBE2D2	hsa-miR-6715a-3p	92.9729	NM_003339
UBE2D2	hsa-miR-3684	92.855	NM_003339
UBE2D2	hsa-miR-7849-3p	92.67	NM_003339
UBE2D2	hsa-miR-144-3p	92.6138	NM_003339
UBE2D2	hsa-miR-2113	92.4697	NM_003339
UBE2D2	hsa-miR-130b-3p	92.0912	NM_003339
UBE2D2	hsa-miR-4295	92.0912	NM_003339
UBE2D2	hsa-miR-130a-3p	92.0912	NM_003339
UBE2D2	hsa-miR-301a-3p	92.0912	NM_003339
UBE2D2	hsa-miR-3666	92.0912	NM_003339
UBE2D2	hsa-miR-301b-3p	92.0912	NM_003339
UBE2D2	hsa-miR-130b-5p	90.7863	NM_003339
UBE2D2	hsa-miR-5093	90.7384	NM_003339
UBE2D2	hsa-miR-3646	90.5539	NM_003339
UBE2D2	hsa-miR-4457	90.5287	NM_003339
UBE2D2	hsa-miR-12127	90.3045	NM_003339
UBE2D2	hsa-miR-4726-3p	89.462	NM_003339
UBE2D2	hsa-miR-4274	89.1011	NM_003339
UBE2D2	hsa-miR-4753-3p	88.8983	NM_003339
UBE2D2	hsa-miR-433-3p	88.7758	NM_003339
UBE2D2	hsa-miR-4474-5p	88.3736	NM_003339
UBE2D2	hsa-miR-587	87.6369	NM_003339
UBE2D2	hsa-miR-6077	87.5307	NM_003339
UBE2D2	hsa-miR-548ap-3p	86.9081	NM_003339
UBE2D2	hsa-miR-548aa	86.9081	NM_003339
UBE2D2	hsa-miR-548t-3p	86.9081	NM_003339
UBE2D2	hsa-miR-6864-5p	86.6438	NM_003339
UBE2D2	hsa-miR-6754-3p	86.2422	NM_003339
UBE2D2	hsa-miR-3662	85.5814	NM_003339
UBE2D2	hsa-miR-193a-5p	85.1045	NM_003339
UBE2D2	hsa-miR-150-3p	85.004	NM_003339
UBE2D2	hsa-miR-6759-5p	84.8401	NM_003339
UBE2D2	hsa-miR-4695-5p	83.9464	NM_003339

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Motifs and transcription factors (TFs) regulating UBE2D2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
UBE2D2	metacluster_183.4	ETS1 (inferredBy_Orthology).
UBE2D2	transfac_pro__M05619	ZSCAN5C (directAnnotation).
UBE2D2	metacluster_141.4	GLIS2 (directAnnotation).
UBE2D2	transfac_pro__M05860	ZNF548 (directAnnotation).
UBE2D2	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
UBE2D2	hocomoco__ZBT14_HUMAN.H11MO.0.C	ZBTB14 (directAnnotation).
UBE2D2	taipale_cyt_meth__KLF3_NRCCGCAGCCCN_FL_meth_repr	KLF3 (directAnnotation).
UBE2D2	metacluster_45.4	E2F2 (directAnnotation).
UBE2D2	kznf__ZNF2_Imbeault2017_OM_RCADE	ZNF2 (directAnnotation).
UBE2D2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
UBE2D2	jaspar__MA1460.1	YY1 (inferredBy_Orthology).
UBE2D2	taipale_tf_pairs__E2F1_NHLH1_SGCGCCNNNNNNNNNNNNCAGCTGNN_CAP_repr	E2F1; NHLH1 (directAnnotation).
UBE2D2	transfac_pro__M01269	NR4A2 (directAnnotation).
UBE2D2	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
UBE2D2	hdpi__ELF2	ELF2 (directAnnotation).
UBE2D2	swissregulon__hs__ELK1	ELK1 (directAnnotation).
UBE2D2	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
UBE2D2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
UBE2D2	taipale_tf_pairs__ETV5_HOXA13_NNCGGAWGTNRTWAA_CAP	ETV5; HOXA13 (directAnnotation).
UBE2D2	metacluster_161.4	LHX9 (directAnnotation).
UBE2D2	transfac_pro__M04748	GABPA (directAnnotation).
UBE2D2	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
UBE2D2	metacluster_161.3	LHX9 (directAnnotation).
UBE2D2	metacluster_26.9	ZNF354B (directAnnotation).
UBE2D2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
UBE2D2	transfac_pro__M02089	E2F3 (directAnnotation).
UBE2D2	transfac_pro__M02898	SMAD3 (directAnnotation).
UBE2D2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
UBE2D2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
UBE2D2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
UBE2D2	hdpi__HIP2	UBE2K (directAnnotation).
UBE2D2	hdpi__NRL	NRL (directAnnotation).
UBE2D2	transfac_pro__M00430	E2F1 (directAnnotation).
UBE2D2	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
UBE2D2	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
UBE2D2	transfac_pro__M07329	SP7 (directAnnotation).
UBE2D2	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
UBE2D2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
UBE2D2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
UBE2D2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
UBE2D2	transfac_pro__M07436	WT1 (directAnnotation).
UBE2D2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
UBE2D2	transfac_pro__M01837	KLF11 (directAnnotation).
UBE2D2	transfac_pro__M07310	SP5 (directAnnotation).
UBE2D2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
UBE2D2	transfac_pro__M04817	ZBTB33 (directAnnotation).
UBE2D2	swissregulon__hs__KLF6	KLF6 (directAnnotation).
UBE2D2	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
UBE2D2	transfac_pro__M00716	ZBTB14 (directAnnotation).
UBE2D2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
UBE2D2	"(R,R)-2,3-Butanediol"	DB02418	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."