Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | NK cells | -0.381045 | 1.44e-02 |
GSE197268_Tisa-cel | patients | Peripheral blood mononuclear cells | Acute lymphoblastic leukemia | Large B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | tisa-cel (CAR-T) | pre | NK cells | 0.268105 | 2.75e-21 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | post | NK cells | 0.670217 | 0.00e+00 |
GSE111014 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | pre | NK cells | -0.616538 | 2.92e-04 |
GSE108397 | 451Lu cell line | Cell line | Melanoma | Melanoma | Targeted therapy | PLX-4720 | NA | Malignant cells | -0.333883 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
TPST2 | transfac_pro__M01010 | HMGA1; HMGA2 (directAnnotation). |
TPST2 | metacluster_12.1 | ZNF3 (directAnnotation). |
TPST2 | tfdimers__MD00019 | PAX4 (directAnnotation). |
TPST2 | taipale_tf_pairs__CUX1_SOX15_NATCRATNNNNNNNAACAATRS_CAP_repr | CUX1; SOX15 (directAnnotation). |
TPST2 | transfac_pro__M03797 | MSX2 (directAnnotation). |
TPST2 | metacluster_77.9 | SOX21 (inferredBy_Orthology). |
TPST2 | metacluster_65.17 | ZNF667 (directAnnotation). ZSCAN21 (inferredBy_Orthology). |
TPST2 | transfac_pro__M02015 | FOXA3 (directAnnotation). |
TPST2 | taipale_tf_pairs__TEAD4_HOXB13_RGAATGCNNRTAAA_CAP | HOXB13; TEAD4 (directAnnotation). |
TPST2 | kznf__ZNF184_Schmitges2016_RCADE | ZNF184 (directAnnotation). |
TPST2 | transfac_public__M00266 | FOXC2 (inferredBy_Orthology). |
TPST2 | tfdimers__MD00280 | E2F1; OTX1; OTX2 (directAnnotation). |
TPST2 | transfac_pro__M05974 | ZNF701 (directAnnotation). |
TPST2 | tfdimers__MD00181 | DBP; E2F1 (directAnnotation). |
TPST2 | metacluster_44.13 | NKX3-1; NKX3-2 (directAnnotation). |
TPST2 | transfac_pro__M06760 | ZNF443 (directAnnotation). |
TPST2 | hocomoco__SPDEF_HUMAN.H11MO.0.D | SPDEF (directAnnotation). |
TPST2 | transfac_pro__M06478 | ZNF433 (directAnnotation). |
TPST2 | taipale_tf_pairs__POU2F1_FOXO6_RMATATKCNNNNNNNNNNNNNRWMAACA_CAP_repr | FOXO6; POU2F1 (directAnnotation). |
TPST2 | transfac_pro__M04829 | STAT3 (directAnnotation). |
TPST2 | taipale_tf_pairs__TEAD4_TBX21_ARGTGTKRNNNNNRGWATGY_CAP | TBX21; TEAD4 (directAnnotation). |
TPST2 | metacluster_74.7 | HNF1B (directAnnotation). |
TPST2 | flyfactorsurvey__SuH_FlyReg_FBgn0004837 | RBPJ (inferredBy_Orthology). |
TPST2 | tfdimers__MD00128 | CDX2; PDX1 (directAnnotation). |
TPST2 | jaspar__MA0684.2 | RUNX3 (directAnnotation). |
TPST2 | metacluster_79.39 | ATF6B (directAnnotation). |
TPST2 | transfac_pro__M06054 | ZNF99 (directAnnotation). |
TPST2 | jaspar__MA1154.1 | ZNF282 (directAnnotation). |
TPST2 | metacluster_106.2 | ZBTB32 (directAnnotation). |
TPST2 | transfac_pro__M05626 | ZNF780A (directAnnotation). |
TPST2 | metacluster_78.16 | PAX7 (directAnnotation). |
TPST2 | transfac_pro__M12556 | ETV4 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |