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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TPD52

Summary for TPD52

Gene information	Gene symbol	TPD52
	Ensembl ID	ENSG00000076554
	Entrez ID	7163
	Gene name	tumor protein D52
	Synonyms	D52\|hD52\|N8L
	Gene type	protein_coding
	UniProtAcc	P55327

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Dataset with differentially expressed gene: TPD52

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.266356	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.273663	2.80e-45
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.265942	2.78e-39
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.314789	1.20e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.373752	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.346125	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.481331	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.471995	0.00e+00

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Expression of TPD52 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TPD52

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TPD52	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TPD52

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TPD52	hsa-miR-636	97.5923	NM_001287144
TPD52	hsa-miR-589-3p	95.8978	NM_001025252
TPD52	hsa-miR-651-3p	95.7009	NM_001025252
TPD52	hsa-miR-6835-3p	95.0889	NM_001287144
TPD52	hsa-miR-5002-5p	94.7468	NM_001287144
TPD52	hsa-miR-548t-5p	94.1188	NM_001287144
TPD52	hsa-miR-548az-5p	94.1188	NM_001287144
TPD52	hsa-miR-495-5p	92.3973	NM_001025252
TPD52	hsa-miR-4724-5p	90.2121	NM_001025252
TPD52	hsa-miR-5009-3p	89.105	NM_001025252
TPD52	hsa-miR-9-3p	89.037	NM_001287144
TPD52	hsa-miR-34a-5p	88.8087	NM_001287144
TPD52	hsa-miR-449a	88.8087	NM_001287144
TPD52	hsa-miR-1284	88.1297	NM_001287144
TPD52	hsa-miR-6165	86.7214	NM_001025252
TPD52	hsa-miR-4677-3p	85.9959	NM_001025252
TPD52	hsa-miR-4503	83.312	NM_001025252
TPD52	hsa-miR-34c-5p	83.2612	NM_001287144
TPD52	hsa-miR-449b-5p	83.2612	NM_001287144
TPD52	hsa-miR-6868-5p	81.7905	NM_001287144
TPD52	hsa-miR-378g	81.6071	NM_001025252
TPD52	hsa-miR-8057	81.569	NM_001025252
TPD52	hsa-miR-570-3p	81.363	NM_001025252
TPD52	hsa-miR-5702	81.3199	NM_001025252
TPD52	hsa-miR-12120	81.0834	NM_001025252

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Motifs and transcription factors (TFs) regulating TPD52

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TPD52	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TPD52	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
TPD52	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
TPD52	transfac_pro__M02089	E2F3 (directAnnotation).
TPD52	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TPD52	transfac_pro__M04817	ZBTB33 (directAnnotation).
TPD52	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
TPD52	tfdimers__MD00483	ZBTB14 (directAnnotation).
TPD52	cisbp__M07938	E2F1 (directAnnotation).
TPD52	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
TPD52	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TPD52	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
TPD52	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TPD52	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TPD52	transfac_pro__M12697	ZNF142 (directAnnotation).
TPD52	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TPD52	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TPD52	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TPD52	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
TPD52	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TPD52	transfac_pro__M01253	CNOT3 (directAnnotation).
TPD52	transfac_pro__M02090	E2F4 (directAnnotation).
TPD52	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
TPD52	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TPD52	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
TPD52	taipale_tf_pairs__MYBL1_EOMES_NNSYGNCNAACNNNNNNCACRCNN_CAP_repr	EOMES; MYBL1 (directAnnotation).
TPD52	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
TPD52	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
TPD52	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TPD52	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
TPD52	kznf__ZNF2_Imbeault2017_RP_ChIP-seq	ZNF2 (directAnnotation).
TPD52	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
TPD52	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TPD52	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TPD52	metacluster_3.10	KLF2; KLF4 (directAnnotation).
TPD52	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TPD52	hdpi__NRL	NRL (directAnnotation).
TPD52	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TPD52	hdpi__FEZF2	FEZF2 (directAnnotation).
TPD52	transfac_pro__M07310	SP5 (directAnnotation).
TPD52	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TPD52	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TPD52	hdpi__HTATIP2	HTATIP2 (directAnnotation).
TPD52	hdpi__HIP2	UBE2K (directAnnotation).
TPD52	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
TPD52	transfac_pro__M02898	SMAD3 (directAnnotation).
TPD52	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TPD52	transfac_pro__M00430	E2F1 (directAnnotation).
TPD52	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
TPD52	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."