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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TP53INP1

Summary for TP53INP1

Gene information	Gene symbol	TP53INP1
	Ensembl ID	ENSG00000164938
	Entrez ID	94241
	Gene name	tumor protein p53 inducible nuclear protein 1
	Synonyms	DKFZp434M1317\|FLJ22139\|P53DINP1\|SIP\|Teap\|TP53INP1A\|TP53INP1B
	Gene type	protein_coding
	UniProtAcc	Q96A56

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Dataset with differentially expressed gene: TP53INP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.478263	1.74e-35
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Plasma cells	0.328685	0.00e+00
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	0.759444	8.58e-17
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.524904	3.39e-08
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.324993	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.326068	0.00e+00

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Expression of TP53INP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TP53INP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TP53INP1	Regulation by the Disease Microenvironment
TP53INP1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TP53INP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TP53INP1	hsa-miR-3662	99.6344	NM_033285
TP53INP1	hsa-miR-3163	99.6285	NM_001135733
TP53INP1	hsa-miR-8485	99.5954	NM_033285
TP53INP1	hsa-miR-1297	99.5541	NM_001135733
TP53INP1	hsa-miR-26b-5p	99.0929	NM_001135733
TP53INP1	hsa-miR-26a-5p	99.0929	NM_001135733
TP53INP1	hsa-miR-4465	98.6906	NM_001135733
TP53INP1	hsa-miR-3646	97.5013	NM_033285
TP53INP1	hsa-miR-497-3p	96.6106	NM_001135733
TP53INP1	hsa-miR-1305	96.3057	NM_001135733
TP53INP1	hsa-miR-3613-3p	95.8587	NM_001135733
TP53INP1	hsa-miR-4708-3p	95.5771	NM_001135733
TP53INP1	hsa-miR-590-3p	95.5252	NM_001135733
TP53INP1	hsa-miR-3919	95.4316	NM_001135733
TP53INP1	hsa-miR-30d-5p	95.3659	NM_001135733
TP53INP1	hsa-miR-30e-5p	95.3659	NM_001135733
TP53INP1	hsa-miR-30b-5p	95.3659	NM_001135733
TP53INP1	hsa-miR-30c-5p	95.3659	NM_001135733
TP53INP1	hsa-miR-30a-5p	95.3659	NM_001135733
TP53INP1	hsa-miR-153-3p	95.2394	NM_001135733
TP53INP1	hsa-miR-3148	95.1706	NM_033285
TP53INP1	hsa-miR-155-5p	94.9295	NM_001135733
TP53INP1	hsa-miR-3941	94.8687	NM_033285
TP53INP1	hsa-miR-3177-5p	94.6907	NM_033285
TP53INP1	hsa-miR-570-3p	94.4409	NM_001135733
TP53INP1	hsa-miR-802	94.1692	NM_033285
TP53INP1	hsa-miR-504-5p	94.1022	NM_001135733
TP53INP1	hsa-miR-4725-5p	94.1022	NM_001135733
TP53INP1	hsa-miR-7-1-3p	93.8826	NM_001135733
TP53INP1	hsa-miR-7-2-3p	93.8826	NM_001135733
TP53INP1	hsa-miR-22-3p	93.789	NM_001135733
TP53INP1	hsa-miR-3180-5p	93.6897	NM_001135733
TP53INP1	hsa-miR-548aj-3p	93.329	NM_001135733
TP53INP1	hsa-miR-548x-3p	93.329	NM_001135733
TP53INP1	hsa-miR-548ac	92.7471	NM_001135733
TP53INP1	hsa-miR-548h-3p	92.7471	NM_001135733
TP53INP1	hsa-miR-548z	92.7471	NM_001135733
TP53INP1	hsa-miR-548d-3p	92.7471	NM_001135733
TP53INP1	hsa-miR-548bb-3p	92.7471	NM_001135733
TP53INP1	hsa-miR-12124	92.4498	NM_001135733
TP53INP1	hsa-miR-3660	92.2471	NM_033285
TP53INP1	hsa-miR-4526	92.2471	NM_033285
TP53INP1	hsa-miR-580-3p	92.0275	NM_001135733
TP53INP1	hsa-miR-548ah-3p	91.8249	NM_001135733
TP53INP1	hsa-miR-548am-3p	91.8249	NM_001135733
TP53INP1	hsa-miR-548ae-3p	91.8249	NM_001135733
TP53INP1	hsa-miR-548j-3p	91.8249	NM_001135733
TP53INP1	hsa-miR-548aq-3p	91.8249	NM_001135733
TP53INP1	hsa-miR-6830-3p	91.3206	NM_001135733
TP53INP1	hsa-miR-548ar-3p	91.2908	NM_001135733

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Motifs and transcription factors (TFs) regulating TP53INP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TP53INP1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
TP53INP1	metacluster_163.2	ZNF682 (directAnnotation).
TP53INP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
TP53INP1	transfac_pro__M04916	TAF1 (directAnnotation).
TP53INP1	metacluster_170.1	ZNF460; ZNF460; ZNF468; ZNF468 (directAnnotation).
TP53INP1	transfac_pro__M00938	E2F1 (directAnnotation).
TP53INP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TP53INP1	transfac_pro__M02090	E2F4 (directAnnotation).
TP53INP1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TP53INP1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
TP53INP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TP53INP1	transfac_pro__M01303	SP1 (directAnnotation).
TP53INP1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
TP53INP1	transfac_pro__M06438	ZNF227 (directAnnotation).
TP53INP1	transfac_pro__M02082	ISL2 (directAnnotation).
TP53INP1	transfac_pro__M06754	ZBTB39 (directAnnotation).
TP53INP1	transfac_pro__M05525	ZBTB41 (directAnnotation).
TP53INP1	tfdimers__MD00018	ELF1; ELF2; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV4; ETV6; ETV7; FLI1; GABPA; GABPB1; SPI1; SPIB; TAF6; TBP (directAnnotation).
TP53INP1	metacluster_179.5	MEF2A; MEF2A; MEF2A; MEF2A (directAnnotation).
TP53INP1	tfdimers__MD00195	CDX2; FOXG1; FOXO1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."