Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: TMEM65

Summary for TMEM65

Gene information	Gene symbol	TMEM65
	Ensembl ID	ENSG00000164983
	Entrez ID	157378
	Gene name	transmembrane protein 65
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q6PI78

Top

Dataset with differentially expressed gene: TMEM65

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.27838	1.01e-06
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.281352	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.31541	1.39e-23

Top

Expression of TMEM65 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to TMEM65

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating TMEM65

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TMEM65	hsa-miR-542-3p	99.3444	NM_194291
TMEM65	hsa-miR-656-3p	99.1158	NM_194291
TMEM65	hsa-miR-5692a	98.7674	NM_194291
TMEM65	hsa-miR-498-3p	98.3797	NM_194291
TMEM65	hsa-miR-101-3p	97.9979	NM_194291
TMEM65	hsa-miR-4698	97.1881	NM_194291
TMEM65	hsa-miR-449b-3p	97.0164	NM_194291
TMEM65	hsa-miR-8063	95.719	NM_194291
TMEM65	hsa-miR-4714-3p	95.2025	NM_194291
TMEM65	hsa-miR-4724-3p	94.4228	NM_194291
TMEM65	hsa-miR-7-2-3p	94.0867	NM_194291
TMEM65	hsa-miR-7-1-3p	94.0867	NM_194291
TMEM65	hsa-miR-559	93.8479	NM_194291
TMEM65	hsa-miR-3973	93.7514	NM_194291
TMEM65	hsa-miR-12135	93.257	NM_194291
TMEM65	hsa-let-7i-5p	92.3631	NM_194291
TMEM65	hsa-miR-4500	92.3631	NM_194291
TMEM65	hsa-let-7g-5p	92.3631	NM_194291
TMEM65	hsa-miR-4282	92.2915	NM_194291
TMEM65	hsa-miR-548i	92.111	NM_194291
TMEM65	hsa-miR-548bb-5p	92.111	NM_194291
TMEM65	hsa-miR-548aq-5p	92.111	NM_194291
TMEM65	hsa-miR-548c-5p	92.111	NM_194291
TMEM65	hsa-miR-548d-5p	92.111	NM_194291
TMEM65	hsa-miR-548h-5p	92.111	NM_194291
TMEM65	hsa-miR-548ae-5p	92.111	NM_194291
TMEM65	hsa-miR-548ar-5p	92.111	NM_194291
TMEM65	hsa-miR-548ap-5p	92.111	NM_194291
TMEM65	hsa-miR-548ad-5p	92.111	NM_194291
TMEM65	hsa-miR-548w	92.111	NM_194291
TMEM65	hsa-miR-548a-5p	92.111	NM_194291
TMEM65	hsa-miR-548o-5p	92.111	NM_194291
TMEM65	hsa-miR-548as-5p	92.111	NM_194291
TMEM65	hsa-miR-548ab	92.111	NM_194291
TMEM65	hsa-miR-548am-5p	92.111	NM_194291
TMEM65	hsa-miR-548j-5p	92.111	NM_194291
TMEM65	hsa-miR-548y	92.111	NM_194291
TMEM65	hsa-miR-548ay-5p	92.111	NM_194291
TMEM65	hsa-miR-548b-5p	92.111	NM_194291
TMEM65	hsa-miR-548ak	92.111	NM_194291
TMEM65	hsa-miR-548au-5p	92.111	NM_194291
TMEM65	hsa-miR-587	92.0763	NM_194291
TMEM65	hsa-miR-518e-5p	92.0623	NM_194291
TMEM65	hsa-miR-518d-5p	92.0623	NM_194291
TMEM65	hsa-miR-526a-5p	92.0623	NM_194291
TMEM65	hsa-miR-518f-5p	92.0623	NM_194291
TMEM65	hsa-miR-520c-5p	92.0623	NM_194291
TMEM65	hsa-miR-522-5p	92.0623	NM_194291
TMEM65	hsa-miR-523-5p	92.0623	NM_194291
TMEM65	hsa-miR-519b-5p	92.0623	NM_194291

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating TMEM65

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TMEM65	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TMEM65	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TMEM65	cisbp__M00249	WT1 (directAnnotation).
TMEM65	transfac_pro__M01122	ZNF219 (directAnnotation).
TMEM65	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TMEM65	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TMEM65	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
TMEM65	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TMEM65	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TMEM65	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
TMEM65	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
TMEM65	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TMEM65	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TMEM65	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
TMEM65	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
TMEM65	metacluster_84.2	RARA (directAnnotation).
TMEM65	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
TMEM65	transfac_pro__M01253	CNOT3 (directAnnotation).
TMEM65	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TMEM65	metacluster_3.10	KLF2; KLF4 (directAnnotation).
TMEM65	jaspar__MA1721.1	ZNF93 (directAnnotation).
TMEM65	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
TMEM65	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
TMEM65	transfac_pro__M05479	ZNF580 (directAnnotation).
TMEM65	jaspar__MA1122.1	TFDP1 (directAnnotation).
TMEM65	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TMEM65	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
TMEM65	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TMEM65	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
TMEM65	tfdimers__MD00151	CHURC1 (directAnnotation).
TMEM65	tfdimers__MD00391	KLF4 (directAnnotation).
TMEM65	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
TMEM65	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
TMEM65	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
TMEM65	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
TMEM65	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
TMEM65	transfac_pro__M01973	PLAG1 (directAnnotation).
TMEM65	transfac_pro__M12697	ZNF142 (directAnnotation).
TMEM65	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
TMEM65	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TMEM65	jaspar__MA0748.2	YY2 (directAnnotation).
TMEM65	transfac_pro__M01303	SP1 (directAnnotation).
TMEM65	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
TMEM65	metacluster_3.14	WT1; WT1 (directAnnotation).
TMEM65	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
TMEM65	transfac_public__M00491	PATZ1 (directAnnotation).
TMEM65	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
TMEM65	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
TMEM65	transfac_pro__M07397	ZNF148 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."