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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: TIMP2

Summary for TIMP2

Gene informationGene symbol

TIMP2

Ensembl ID

ENSG00000035862

Entrez ID

7077

Gene nameTIMP metallopeptidase inhibitor 2
SynonymsCSC-21K
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: TIMP2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells0.2836929.20e-22

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreMono/Macro0.3014511.15e-17

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpostMono/Macro0.4379573.39e-05

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreMono/Macro0.2817953.91e-14

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preMono/Macro0.3957270.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postNeutrophils-0.2976514.13e-05

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.4343780.00e+00

GSE131984_JQ1

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1NAMalignant cells0.3208271.53e-15

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.8256370.00e+00

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.4291492.62e-21

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepreMalignant cells0.8684260.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.7730250.00e+00

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells0.3690090.00e+00

GSE164897_VemCob

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenib + combimetinibNAMalignant cells0.3315090.00e+00

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Expression of TIMP2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to TIMP2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

TIMP2

Regulation by the Disease Microenvironment
Page: 1

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MicroRNAs (miRNA) regulating TIMP2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
TIMP2hsa-miR-544a90.729NM_003255
TIMP2hsa-miR-444389.2167NM_003255
TIMP2hsa-miR-452-5p88.7904NM_003255
TIMP2hsa-miR-892c-3p88.7904NM_003255
TIMP2hsa-miR-4676-3p88.7904NM_003255
TIMP2hsa-miR-365988.4507NM_003255
TIMP2hsa-miR-1211988.2135NM_003255
TIMP2hsa-miR-42987.8284NM_003255
TIMP2hsa-miR-200b-3p87.8284NM_003255
TIMP2hsa-miR-200c-3p87.8284NM_003255
TIMP2hsa-miR-5187-5p87.5355NM_003255
TIMP2hsa-miR-4776-5p87.0237NM_003255
TIMP2hsa-miR-18a-3p85.3413NM_003255
TIMP2hsa-miR-338-3p84.4141NM_003255
TIMP2hsa-miR-6515-5p83.3517NM_003255
TIMP2hsa-miR-607982.7756NM_003255
TIMP2hsa-miR-1343-5p80.9192NM_003255
TIMP2hsa-miR-453580.4284NM_003255
TIMP2hsa-miR-4701-5p80.3962NM_003255
TIMP2hsa-miR-58880.3962NM_003255
TIMP2hsa-miR-428380.1478NM_003255
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Motifs and transcription factors (TFs) regulating TIMP2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
TIMP2kznf__ZNF584_Imbeault2017_OM_RCADEZNF584 (directAnnotation).
TIMP2transfac_pro__M05877ZNF467 (inferredBy_Orthology).
TIMP2tfdimers__MD00095ELF1; NEUROD1 (directAnnotation).
TIMP2tfdimers__MD00208IRF1; LTF (directAnnotation).
TIMP2metacluster_22.20MAFG (directAnnotation).
TIMP2metacluster_26.3ZNF232 (directAnnotation).
TIMP2metacluster_100.2ZNF440 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."