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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: THRAP3

Summary for THRAP3

Gene information	Gene symbol	THRAP3
	Ensembl ID	ENSG00000054118
	Entrez ID	9967
	Gene name	thyroid hormone receptor associated protein 3
	Synonyms	BCLAF2\|TRAP150
	Gene type	protein_coding
	UniProtAcc	Q9Y2W1

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Dataset with differentially expressed gene: THRAP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.388612	2.53e-29
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.293298	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.295325	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.38003	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.268936	7.06e-12
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.262713	2.51e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.487505	4.37e-34
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.371114	2.40e-14
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.542455	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.374619	3.33e-21
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.450128	0.00e+00

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Expression of THRAP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to THRAP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating THRAP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
THRAP3	hsa-miR-3646	94.1116	NM_001321471
THRAP3	hsa-miR-5696	92.6357	NM_001321471
THRAP3	hsa-miR-576-5p	92.4348	NM_001321471
THRAP3	hsa-miR-6828-3p	92.1032	NM_001321471
THRAP3	hsa-miR-767-3p	91.9651	NM_001321471
THRAP3	hsa-miR-29b-2-5p	89.8879	NM_001321471
THRAP3	hsa-miR-4633-5p	88.4882	NM_001321471
THRAP3	hsa-miR-6780a-3p	86.4081	NM_001321471
THRAP3	hsa-miR-133a-3p	85.9718	NM_001321471
THRAP3	hsa-miR-133b	85.9718	NM_001321471
THRAP3	hsa-miR-138-5p	85.9381	NM_001321471
THRAP3	hsa-miR-6809-3p	84.9289	NM_001321471
THRAP3	hsa-miR-494-3p	83.5351	NM_001321471
THRAP3	hsa-miR-3973	82.6872	NM_001321471
THRAP3	hsa-miR-625-3p	82.6644	NM_001321471
THRAP3	hsa-miR-7-2-3p	82.3587	NM_001321471
THRAP3	hsa-miR-7-1-3p	82.3587	NM_001321471
THRAP3	hsa-miR-5000-3p	81.8692	NM_001321471
THRAP3	hsa-miR-7854-3p	81.8417	NM_001321471
THRAP3	hsa-miR-6721-5p	80.8796	NM_001321471
THRAP3	hsa-miR-6783-5p	80.7208	NM_001321471

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Motifs and transcription factors (TFs) regulating THRAP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
THRAP3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
THRAP3	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
THRAP3	jaspar__MA1933.1	SREBF2 (directAnnotation).
THRAP3	jaspar__MA0502.2	NFYB (directAnnotation).
THRAP3	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
THRAP3	taipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_repr	FLI1; FOXI1 (directAnnotation).
THRAP3	transfac_pro__M02089	E2F3 (directAnnotation).
THRAP3	transfac_pro__M02898	SMAD3 (directAnnotation).
THRAP3	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
THRAP3	hdpi__HIP2	UBE2K (directAnnotation).
THRAP3	hdpi__NRL	NRL (directAnnotation).
THRAP3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
THRAP3	transfac_pro__M07329	SP7 (directAnnotation).
THRAP3	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
THRAP3	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
THRAP3	transfac_pro__M07436	WT1 (directAnnotation).
THRAP3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
THRAP3	transfac_pro__M01837	KLF11 (directAnnotation).
THRAP3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
THRAP3	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
THRAP3	swissregulon__hs__KLF6	KLF6 (directAnnotation).
THRAP3	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
THRAP3	transfac_pro__M00716	ZBTB14 (directAnnotation).
THRAP3	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
THRAP3	metacluster_163.2	ZNF682 (directAnnotation).
THRAP3	transfac_pro__M00938	E2F1 (directAnnotation).
THRAP3	transfac_pro__M02090	E2F4 (directAnnotation).
THRAP3	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."