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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TGFBR2

Summary for TGFBR2

Gene information	Gene symbol	TGFBR2
	Ensembl ID	ENSG00000163513
	Entrez ID	7048
	Gene name	transforming growth factor beta receptor 2
	Synonyms	MFS2\|TBR-ii\|TBRII
	Gene type	protein_coding
	UniProtAcc	P37173

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Dataset with differentially expressed gene: TGFBR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.16458	8.75e-03
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.350807	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.328822	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.480014	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.314197	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.251154	1.02e-04
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.289823	3.67e-10
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.381726	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.39813	0.00e+00
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.341973	3.32e-18
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.356124	6.73e-12
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.583037	0.00e+00

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Expression of TGFBR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TGFBR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
TGFBR2	Regulation by the Disease Microenvironment
TGFBR2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating TGFBR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TGFBR2	hsa-miR-5011-5p	100	NM_001024847
TGFBR2	hsa-miR-190a-3p	99.9337	NM_001024847
TGFBR2	hsa-miR-519c-3p	99.5682	NM_001024847
TGFBR2	hsa-miR-519b-3p	99.5682	NM_001024847
TGFBR2	hsa-miR-519a-3p	99.5682	NM_001024847
TGFBR2	hsa-miR-202-5p	98.7653	NM_001024847
TGFBR2	hsa-miR-302e	98.014	NM_001024847
TGFBR2	hsa-miR-548c-3p	96.2731	NM_001024847
TGFBR2	hsa-miR-526b-3p	96.2702	NM_001024847
TGFBR2	hsa-miR-20a-5p	96.2118	NM_001024847
TGFBR2	hsa-miR-106b-5p	96.2118	NM_001024847
TGFBR2	hsa-miR-302a-3p	96.1296	NM_001024847
TGFBR2	hsa-miR-302d-3p	96.1296	NM_001024847
TGFBR2	hsa-miR-302b-3p	96.1296	NM_001024847
TGFBR2	hsa-miR-302c-3p	96.1296	NM_001024847
TGFBR2	hsa-miR-520b-3p	95.9718	NM_001024847
TGFBR2	hsa-miR-520e-3p	95.9718	NM_001024847
TGFBR2	hsa-miR-520c-3p	95.9718	NM_001024847
TGFBR2	hsa-miR-20b-5p	95.9501	NM_001024847
TGFBR2	hsa-miR-106a-5p	95.9501	NM_001024847
TGFBR2	hsa-miR-17-5p	95.9501	NM_001024847
TGFBR2	hsa-miR-93-5p	95.9501	NM_001024847
TGFBR2	hsa-miR-519d-3p	95.9501	NM_001024847
TGFBR2	hsa-miR-520d-3p	94.5085	NM_001024847
TGFBR2	hsa-miR-372-3p	94.5085	NM_001024847
TGFBR2	hsa-miR-520a-3p	94.5085	NM_001024847
TGFBR2	hsa-miR-373-3p	93.8823	NM_001024847
TGFBR2	hsa-miR-204-5p	93.8532	NM_001024847
TGFBR2	hsa-miR-211-5p	93.8532	NM_001024847
TGFBR2	hsa-miR-1200	92.1166	NM_001024847
TGFBR2	hsa-miR-6783-3p	91.5845	NM_001024847
TGFBR2	hsa-miR-544b	91.5451	NM_001024847
TGFBR2	hsa-miR-23a-3p	91.0848	NM_001024847
TGFBR2	hsa-miR-23b-3p	91.0848	NM_001024847
TGFBR2	hsa-miR-23c	91.0848	NM_001024847
TGFBR2	hsa-miR-544a	91.0462	NM_001024847
TGFBR2	hsa-miR-301a-3p	89.8396	NM_001024847
TGFBR2	hsa-miR-301b-3p	89.8396	NM_001024847
TGFBR2	hsa-miR-6844	89.5034	NM_001024847
TGFBR2	hsa-miR-515-5p	89.3424	NM_001024847
TGFBR2	hsa-miR-519e-5p	89.3424	NM_001024847
TGFBR2	hsa-miR-3666	89.251	NM_001024847
TGFBR2	hsa-miR-130a-3p	89.251	NM_001024847
TGFBR2	hsa-miR-454-3p	89.251	NM_001024847
TGFBR2	hsa-miR-4295	89.251	NM_001024847
TGFBR2	hsa-miR-130b-3p	89.251	NM_001024847
TGFBR2	hsa-miR-9-5p	89.1766	NM_001024847
TGFBR2	hsa-miR-1343-3p	89.0931	NM_001024847
TGFBR2	hsa-miR-3924	88.2009	NM_001024847
TGFBR2	hsa-miR-16-1-3p	88.1089	NM_001024847

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Motifs and transcription factors (TFs) regulating TGFBR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TGFBR2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
TGFBR2	transfac_pro__M01199	TRIM28 (directAnnotation).
TGFBR2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
TGFBR2	metacluster_151.2	ZNF23 (directAnnotation).
TGFBR2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TGFBR2	transfac_pro__M03806	ZBTB7C (directAnnotation).
TGFBR2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TGFBR2	jaspar__MA0079.5	SP1 (directAnnotation).
TGFBR2	transfac_pro__M01253	CNOT3 (directAnnotation).
TGFBR2	transfac_pro__M04817	ZBTB33 (directAnnotation).
TGFBR2	cisbp__M07938	E2F1 (directAnnotation).
TGFBR2	transfac_pro__M07270	TEAD4 (directAnnotation).
TGFBR2	metacluster_74.19	HNF1A (inferredBy_Orthology).
TGFBR2	hdpi__NRL	NRL (directAnnotation).
TGFBR2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
TGFBR2	hdpi__FEZF2	FEZF2 (directAnnotation).
TGFBR2	transfac_pro__M07310	SP5 (directAnnotation).
TGFBR2	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
TGFBR2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TGFBR2	metacluster_155.11	SPZ1 (directAnnotation).
TGFBR2	hdpi__HTATIP2	HTATIP2 (directAnnotation).
TGFBR2	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
TGFBR2	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
TGFBR2	transfac_pro__M02089	E2F3 (directAnnotation).
TGFBR2	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
TGFBR2	tfdimers__MD00483	ZBTB14 (directAnnotation).
TGFBR2	transfac_pro__M07317	CTBP1 (directAnnotation).
TGFBR2	transfac_pro__M12697	ZNF142 (directAnnotation).
TGFBR2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TGFBR2	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
TGFBR2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TGFBR2	transfac_pro__M04916	TAF1 (directAnnotation).
TGFBR2	hdpi__RARA	RARA (directAnnotation).
TGFBR2	jaspar__MA1650.1	ZBTB14 (directAnnotation).
TGFBR2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
TGFBR2	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
TGFBR2	cisbp__M08228	PAX5 (directAnnotation).
TGFBR2	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
TGFBR2	transfac_pro__M00938	E2F1 (directAnnotation).
TGFBR2	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TGFBR2	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
TGFBR2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
TGFBR2	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
TGFBR2	transfac_pro__M02090	E2F4 (directAnnotation).
TGFBR2	transfac_pro__M03846	SMAD5 (directAnnotation).
TGFBR2	metacluster_45.4	E2F2 (directAnnotation).
TGFBR2	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
TGFBR2	cisbp__M00343	PAX6 (directAnnotation).
TGFBR2	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
TGFBR2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TGFBR2	"Foreskin fibroblast (neonatal)"	DB10770	biotech
TGFBR2	"Foreskin keratinocyte (neonatal)"	DB10772	biotech
TGFBR2	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."