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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: TCF7L2

Summary for TCF7L2

Gene information	Gene symbol	TCF7L2
	Ensembl ID	ENSG00000148737
	Entrez ID	6934
	Gene name	transcription factor 7 like 2
	Synonyms	TCF-4\|TCF4
	Gene type	protein_coding
	UniProtAcc	Q9NQB0

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Dataset with differentially expressed gene: TCF7L2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.446971	1.38e-40
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	-0.370695	3.35e-17
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	0.30885	1.48e-31
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.357124	0.00e+00

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Expression of TCF7L2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TCF7L2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TCF7L2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TCF7L2	hsa-miR-5011-5p	99.9992	NM_001146285
TCF7L2	hsa-miR-190a-3p	99.9758	NM_001146285
TCF7L2	hsa-miR-499b-3p	99.1834	NM_001198525
TCF7L2	hsa-miR-499a-3p	99.1834	NM_001198525
TCF7L2	hsa-let-7f-2-3p	99.1612	NM_001198525
TCF7L2	hsa-miR-1185-2-3p	99.1612	NM_001198525
TCF7L2	hsa-miR-1185-1-3p	99.1612	NM_001198525
TCF7L2	hsa-miR-548h-3p	98.2803	NM_001146285
TCF7L2	hsa-miR-548ac	98.2803	NM_001146285
TCF7L2	hsa-miR-548d-3p	98.2803	NM_001146285
TCF7L2	hsa-miR-548bb-3p	98.2803	NM_001146285
TCF7L2	hsa-miR-548z	98.2803	NM_001146285
TCF7L2	hsa-miR-493-5p	96.5106	NM_001198525
TCF7L2	hsa-let-7c-3p	96.3901	NM_001146285
TCF7L2	hsa-miR-877-3p	96.2955	NM_001198525
TCF7L2	hsa-miR-135b-5p	96.0797	NM_001198525
TCF7L2	hsa-miR-135a-5p	96.0797	NM_001198525
TCF7L2	hsa-miR-6512-5p	95.6393	NM_001198525
TCF7L2	hsa-miR-4262	94.4199	NM_001198525
TCF7L2	hsa-miR-655-3p	94.2813	NM_001146285
TCF7L2	hsa-miR-374c-5p	94.2813	NM_001146285
TCF7L2	hsa-miR-4261	94.0913	NM_001146285
TCF7L2	hsa-miR-4719	93.9021	NM_001198525
TCF7L2	hsa-miR-524-5p	93.682	NM_001198525
TCF7L2	hsa-miR-520d-5p	93.682	NM_001198525
TCF7L2	hsa-miR-6716-3p	93.6564	NM_001146285
TCF7L2	hsa-miR-513b-5p	93.6402	NM_001198525
TCF7L2	hsa-miR-181a-5p	93.6271	NM_001198525
TCF7L2	hsa-miR-181b-5p	93.6271	NM_001198525
TCF7L2	hsa-miR-181d-5p	93.6271	NM_001198525
TCF7L2	hsa-miR-181c-5p	93.6271	NM_001198525
TCF7L2	hsa-miR-548v	92.9847	NM_001146285
TCF7L2	hsa-miR-4789-5p	92.8594	NM_001198525
TCF7L2	hsa-miR-6716-5p	92.762	NM_001198525
TCF7L2	hsa-let-7g-3p	92.5146	NM_001198525
TCF7L2	hsa-let-7a-2-3p	92.5146	NM_001198525
TCF7L2	hsa-miR-3924	92.413	NM_001198525
TCF7L2	hsa-miR-3135a	92.3472	NM_001198525
TCF7L2	hsa-miR-6851-3p	92.221	NM_001146285
TCF7L2	hsa-miR-3119	91.8936	NM_001198525
TCF7L2	hsa-miR-380-3p	91.6371	NM_001146285
TCF7L2	hsa-miR-3662	91.4982	NM_001146285
TCF7L2	hsa-miR-2115-5p	91.4852	NM_001198525
TCF7L2	hsa-miR-379-3p	91.4105	NM_001146285
TCF7L2	hsa-miR-411-3p	91.4105	NM_001146285
TCF7L2	hsa-miR-664a-3p	91.3528	NM_001146285
TCF7L2	hsa-miR-767-5p	90.9165	NM_001198525
TCF7L2	hsa-miR-328-3p	90.8357	NM_001146285
TCF7L2	hsa-miR-147b-5p	90.6003	NM_001146285
TCF7L2	hsa-miR-4650-3p	90.4499	NM_001198525

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Motifs and transcription factors (TFs) regulating TCF7L2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TCF7L2	metacluster_144.13	HIC1; HIC1 (directAnnotation).
TCF7L2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
TCF7L2	transfac_pro__M02898	SMAD3 (directAnnotation).
TCF7L2	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
TCF7L2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
TCF7L2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TCF7L2	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
TCF7L2	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
TCF7L2	transfac_pro__M07329	SP7 (directAnnotation).
TCF7L2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TCF7L2	tfdimers__MD00029	IKZF2; NKX3-2 (directAnnotation).
TCF7L2	tfdimers__MD00012	ETS1; YY1 (directAnnotation).
TCF7L2	transfac_pro__M06241	ZNF345 (directAnnotation).
TCF7L2	transfac_pro__M06742	ZNF304 (directAnnotation).
TCF7L2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
TCF7L2	tfdimers__MD00342	IRF1; YY1 (directAnnotation).
TCF7L2	transfac_pro__M06943	PBX3 (directAnnotation).
TCF7L2	swissregulon__hs__HSF2	HSF2 (directAnnotation).
TCF7L2	transfac_pro__M06737	ZNF226 (directAnnotation).
TCF7L2	transfac_pro__M05905	ZNF649 (directAnnotation).
TCF7L2	tfdimers__MD00515	ARID3A; KLF4 (directAnnotation).
TCF7L2	jaspar__MA1963.1	SATB1 (directAnnotation).
TCF7L2	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
TCF7L2	metacluster_155.29	ZNF2 (directAnnotation). ZNF2 (inferredBy_Orthology).
TCF7L2	transfac_pro__M06353	ZNF782 (directAnnotation).
TCF7L2	hdpi__FLI1	FLI1 (directAnnotation).
TCF7L2	transfac_pro__M05538	ZNF536 (inferredBy_Orthology).
TCF7L2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
TCF7L2	transfac_pro__M06487	ZNF695 (directAnnotation).
TCF7L2	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
TCF7L2	tfdimers__MD00145	up	Mono/Macro	GSE189460	pre
TCF7L2	tfdimers__MD00145	down	Mono/Macro	GSE207422_Sin	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."