Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE138267 | CDX | Tumor tissue | Lung cancer | Small cell lung cancer (SCLC) | Chemotherapy | NA | NA | Malignant cells | 1.18131 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | B cells | 0.313871 | 1.23e-39 |
GSE169246_PacTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | B cells | 0.363831 | 2.73e-09 |
GSE169246_PacAteTissue | patients | Tumor tissue | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Immunotherapy | atezolizumab + paclitaxel | pre | pDCs | 0.571964 | 1.92e-03 |
GSE207422_Sin | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | pDCs | 0.986621 | 2.93e-02 |
GSE207422_Tor | patients | Tumor tissue | Lung cancer | EGFR/ALK mutation negative non-small cell lung cancer (NSCLC) | Immunotherapy | toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine) | post | Malignant cells | -0.579665 | 2.44e-39 |
GSE189460 | patients | Bone marrow aspirate | Multiple myeloma | Multiple myeloma (MM) | Targeted therapy | bortezomib + melphalan + prednisolone | pre | Malignant cells | 0.530388 | 0.00e+00 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | B cells | -1.62515 | 3.22e-06 |
GSE199333 | patients | Bone marrow aspirate | Acute myeloid leukemia | Primary FLT3-ITD-mutated acute myeloid leukemia (AML) | Targeted therapy | gilteritinib | pre | Malignant cells | -0.341782 | 0.00e+00 |
GSE111014 | patients | Peripheral blood mononuclear cells | Chronic lymphocytic leukemia | Chronic lymphocytic leukemia (CLL) | Targeted therapy | ibrutinib | post | Malignant cells | -0.263428 | 2.40e-09 |
Gene symbol | motif | TF_highConf |
TCF4 | taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr | ERF; HOXA3 (directAnnotation). |
TCF4 | taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP | ETV5; EVX1 (directAnnotation). |
TCF4 | taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr | ETV2; HOXA2 (directAnnotation). |
TCF4 | taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP | ELK1; FOXO1 (directAnnotation). |
TCF4 | taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD | ZBTB2 (directAnnotation). |
TCF4 | swissregulon__hs__GMEB2 | GMEB2 (directAnnotation). |
TCF4 | taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP | ETV4; FOXO1 (directAnnotation). |
TCF4 | jaspar__MA1708.1 | ETV7 (directAnnotation). |
TCF4 | taipale_cyt_meth__CDX2_NRTCGTAAANNN_eDBD_meth | CDX2 (directAnnotation). |
TCF4 | taipale_tf_pairs__ETV2_FOXI1_RSCGGATGTTKW_CAP | ETV2; FOXI1 (directAnnotation). |
TCF4 | transfac_pro__M06249 | ZNF616 (directAnnotation). |
TCF4 | taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP | ELK3; HOXB2 (directAnnotation). |
TCF4 | taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP | ELK1; FOXI1 (directAnnotation). |
TCF4 | metacluster_183.4 | ETS1 (inferredBy_Orthology). |
TCF4 | transfac_pro__M06173 | ZNF85 (directAnnotation). |
TCF4 | metacluster_144.8 | ZNF30; ZNF30 (directAnnotation). |
TCF4 | metacluster_144.3 | ZNF704; ZNF704 (directAnnotation). |
TCF4 | cisbp__M00249 | WT1 (directAnnotation). |
TCF4 | transfac_pro__M01122 | ZNF219 (directAnnotation). |
TCF4 | metacluster_151.2 | ZNF23 (directAnnotation). |
TCF4 | dbtfbs__ZNF407_representative_N1 | ZNF407 (directAnnotation). |
TCF4 | kznf__ZNF571_Imbeault2017_OM_RCADE | ZNF571 (directAnnotation). |
TCF4 | metacluster_7.5 | PLAGL1; PLAGL1 (directAnnotation). |
TCF4 | taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr | E2F1; ELK1 (directAnnotation). |
TCF4 | swissregulon__hs__GLIS2 | GLIS2 (directAnnotation). |
TCF4 | kznf__ZNF100_Imbeault2017_RP_RCADE | ZNF100 (directAnnotation). |
TCF4 | metacluster_151.1 | KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation). |
TCF4 | taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr | GCM1; SPDEF (directAnnotation). |
TCF4 | metacluster_84.2 | RARA (directAnnotation). |
TCF4 | homer__TWVGGTCCGC_HINFP | HINFP (directAnnotation). |
TCF4 | metacluster_23.9 | GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology). |
TCF4 | transfac_pro__M01253 | CNOT3 (directAnnotation). |
TCF4 | dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1 | ZSCAN30 (directAnnotation). |
TCF4 | metacluster_170.2 | KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology). |
TCF4 | jaspar__MA1721.1 | ZNF93 (directAnnotation). |
TCF4 | metacluster_195.2 | EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology). |
TCF4 | taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP | ETV5; HES7 (directAnnotation). |
TCF4 | jaspar__MA1122.1 | TFDP1 (directAnnotation). |
TCF4 | taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr | E2F8; TFAP2C (directAnnotation). |
TCF4 | transfac_pro__M01199 | TRIM28 (directAnnotation). |
TCF4 | metacluster_35.2 | EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology). |
TCF4 | tfdimers__MD00151 | CHURC1 (directAnnotation). |
TCF4 | tfdimers__MD00391 | KLF4 (directAnnotation). |
TCF4 | taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP | ETV1; GCM1 (directAnnotation). |
TCF4 | tfdimers__MD00441 | OVOL2; RELA (directAnnotation). |
TCF4 | taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP | ELK1; GCM2 (directAnnotation). |
TCF4 | metacluster_163.1 | KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology). |
TCF4 | transfac_pro__M01973 | PLAG1 (directAnnotation). |
TCF4 | metacluster_196.3 | NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology). |
TCF4 | taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr | E2F1; ELK1 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |