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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TAOK3

Summary for TAOK3

Gene information	Gene symbol	TAOK3
	Ensembl ID	ENSG00000135090
	Entrez ID	51347
	Gene name	TAO kinase 3
	Synonyms	DPK\|JIK\|MAP3K18
	Gene type	protein_coding
	UniProtAcc	Q9H2K8

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Dataset with differentially expressed gene: TAOK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.345845	1.08e-10
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.257151	1.74e-10
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.747862	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.338767	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.46501	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.292864	4.58e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.339858	7.11e-29

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Expression of TAOK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TAOK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAOK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TAOK3	hsa-miR-3202	98.1561	NM_016281
TAOK3	hsa-miR-9983-3p	97.7636	NM_016281
TAOK3	hsa-miR-4795-3p	96.4803	NM_016281
TAOK3	hsa-miR-129-5p	96.3422	NM_016281
TAOK3	hsa-miR-5197-5p	96.019	NM_016281
TAOK3	hsa-miR-499b-3p	94.0425	NM_016281
TAOK3	hsa-miR-499a-3p	94.0425	NM_016281
TAOK3	hsa-miR-106b-5p	93.3161	NM_016281
TAOK3	hsa-miR-20a-5p	93.3161	NM_016281
TAOK3	hsa-miR-3919	93.1332	NM_016281
TAOK3	hsa-miR-548x-5p	92.6536	NM_016281
TAOK3	hsa-miR-548g-5p	92.6536	NM_016281
TAOK3	hsa-miR-548f-5p	92.6536	NM_016281
TAOK3	hsa-miR-548aj-5p	92.6536	NM_016281
TAOK3	hsa-miR-17-5p	92.1514	NM_016281
TAOK3	hsa-miR-526b-3p	92.1514	NM_016281
TAOK3	hsa-miR-20b-5p	92.1514	NM_016281
TAOK3	hsa-miR-519d-3p	92.1514	NM_016281
TAOK3	hsa-miR-106a-5p	92.1514	NM_016281
TAOK3	hsa-miR-93-5p	92.1514	NM_016281
TAOK3	hsa-miR-3163	91.4614	NM_016281
TAOK3	hsa-miR-5582-3p	90.388	NM_016281
TAOK3	hsa-miR-4725-3p	90.3825	NM_016281
TAOK3	hsa-miR-6780b-5p	90.3825	NM_016281
TAOK3	hsa-miR-4269	89.8509	NM_016281
TAOK3	hsa-miR-6715b-5p	89.8509	NM_016281
TAOK3	hsa-miR-153-5p	89.7829	NM_016281
TAOK3	hsa-miR-8082	89.1024	NM_016281
TAOK3	hsa-miR-4534	88.6407	NM_016281
TAOK3	hsa-miR-1284	88.2828	NM_016281
TAOK3	hsa-miR-2110	88.0168	NM_016281
TAOK3	hsa-miR-4772-3p	87.4294	NM_016281
TAOK3	hsa-miR-4271	87.2832	NM_016281
TAOK3	hsa-miR-494-3p	86.8146	NM_016281
TAOK3	hsa-miR-6885-3p	86.2444	NM_016281
TAOK3	hsa-miR-922	84.0817	NM_016281
TAOK3	hsa-miR-4680-3p	83.8724	NM_016281
TAOK3	hsa-miR-4694-3p	83.4732	NM_016281
TAOK3	hsa-miR-522-3p	83.4732	NM_016281
TAOK3	hsa-miR-224-3p	83.4732	NM_016281
TAOK3	hsa-miR-6868-3p	83.4575	NM_016281
TAOK3	hsa-miR-335-3p	83.4216	NM_016281
TAOK3	hsa-miR-4666a-3p	83.2222	NM_016281
TAOK3	hsa-miR-338-5p	82.7891	NM_016281
TAOK3	hsa-miR-5196-5p	82.1284	NM_016281
TAOK3	hsa-miR-4747-5p	82.1284	NM_016281
TAOK3	hsa-miR-181b-3p	82.1253	NM_016281
TAOK3	hsa-miR-181b-2-3p	82.1253	NM_016281
TAOK3	hsa-miR-4420	82.1253	NM_016281
TAOK3	hsa-miR-126-5p	81.6083	NM_016281

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Motifs and transcription factors (TFs) regulating TAOK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TAOK3	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
TAOK3	cisbp__M00249	WT1 (directAnnotation).
TAOK3	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
TAOK3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
TAOK3	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
TAOK3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
TAOK3	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
TAOK3	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
TAOK3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
TAOK3	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
TAOK3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
TAOK3	metacluster_84.2	RARA (directAnnotation).
TAOK3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
TAOK3	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
TAOK3	transfac_pro__M01253	CNOT3 (directAnnotation).
TAOK3	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
TAOK3	metacluster_3.10	KLF2; KLF4 (directAnnotation).
TAOK3	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
TAOK3	jaspar__MA1721.1	ZNF93 (directAnnotation).
TAOK3	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
TAOK3	swissregulon__hs__CHD1	CHD1 (directAnnotation).
TAOK3	transfac_pro__M05479	ZNF580 (directAnnotation).
TAOK3	jaspar__MA1122.1	TFDP1 (directAnnotation).
TAOK3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
TAOK3	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
TAOK3	tfdimers__MD00151	CHURC1 (directAnnotation).
TAOK3	tfdimers__MD00391	KLF4 (directAnnotation).
TAOK3	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
TAOK3	tfdimers__MD00441	OVOL2; RELA (directAnnotation).
TAOK3	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
TAOK3	transfac_pro__M12697	ZNF142 (directAnnotation).
TAOK3	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
TAOK3	transfac_pro__M01303	SP1 (directAnnotation).
TAOK3	metacluster_3.14	WT1; WT1 (directAnnotation).
TAOK3	transfac_public__M00491	PATZ1 (directAnnotation).
TAOK3	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
TAOK3	transfac_pro__M07397	ZNF148 (directAnnotation).
TAOK3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
TAOK3	transfac_pro__M06173	ZNF85 (directAnnotation).
TAOK3	transfac_pro__M06259	ZNF91 (directAnnotation).
TAOK3	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
TAOK3	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
TAOK3	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
TAOK3	transfac_pro__M02089	E2F3 (directAnnotation).
TAOK3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
TAOK3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
TAOK3	transfac_pro__M04817	ZBTB33 (directAnnotation).
TAOK3	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
TAOK3	tfdimers__MD00483	ZBTB14 (directAnnotation).
TAOK3	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TAOK3	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."