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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: TAOK1

Summary for TAOK1

Gene information	Gene symbol	TAOK1
	Ensembl ID	ENSG00000160551
	Entrez ID	57551
	Gene name	TAO kinase 1
	Synonyms	FLJ14314\|hKFC-B\|hTAOK1\|KIAA1361\|MAP3K16\|MARKK\|PSK2\|TAO1
	Gene type	protein_coding
	UniProtAcc	Q7L7X3

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Dataset with differentially expressed gene: TAOK1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.16865	9.23e-07
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.260714	4.53e-11
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.376942	1.69e-19

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Expression of TAOK1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to TAOK1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating TAOK1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
TAOK1	hsa-miR-548aj-5p	99.78	NM_020791
TAOK1	hsa-miR-548x-5p	99.78	NM_020791
TAOK1	hsa-miR-548g-5p	99.78	NM_020791
TAOK1	hsa-miR-548f-5p	99.78	NM_020791
TAOK1	hsa-miR-548aw	99.7587	NM_020791
TAOK1	hsa-let-7a-3p	99.7425	NM_020791
TAOK1	hsa-miR-98-3p	99.7425	NM_020791
TAOK1	hsa-let-7b-3p	99.7425	NM_020791
TAOK1	hsa-let-7f-1-3p	99.7425	NM_020791
TAOK1	hsa-miR-4666a-3p	99.5837	NM_025142
TAOK1	hsa-miR-381-3p	99.3635	NM_025142
TAOK1	hsa-miR-507	99.3384	NM_020791
TAOK1	hsa-miR-557	99.2119	NM_020791
TAOK1	hsa-miR-300	99.1276	NM_025142
TAOK1	hsa-miR-450b-5p	99.0448	NM_020791
TAOK1	hsa-miR-335-3p	98.863	NM_020791
TAOK1	hsa-miR-24-3p	98.8505	NM_020791
TAOK1	hsa-miR-5582-5p	98.8371	NM_020791
TAOK1	hsa-let-7c-3p	98.7518	NM_020791
TAOK1	hsa-miR-190a-3p	98.68	NM_020791
TAOK1	hsa-miR-520d-5p	98.5454	NM_020791
TAOK1	hsa-miR-524-5p	98.5454	NM_020791
TAOK1	hsa-miR-655-3p	98.4575	NM_025142
TAOK1	hsa-miR-374c-5p	98.4575	NM_025142
TAOK1	hsa-miR-1468-3p	98.3396	NM_020791
TAOK1	hsa-miR-1277-5p	98.2936	NM_020791
TAOK1	hsa-miR-3148	98.2818	NM_025142
TAOK1	hsa-miR-153-5p	98.0527	NM_020791
TAOK1	hsa-miR-1284	97.8626	NM_025142
TAOK1	hsa-miR-3121-3p	97.5057	NM_020791
TAOK1	hsa-miR-548x-3p	97.505	NM_025142
TAOK1	hsa-miR-548aj-3p	97.505	NM_025142
TAOK1	hsa-miR-19b-3p	97.296	NM_025142
TAOK1	hsa-miR-548j-3p	97.0582	NM_025142
TAOK1	hsa-miR-1207-3p	96.9362	NM_020791
TAOK1	hsa-miR-548ae-3p	96.8134	NM_025142
TAOK1	hsa-miR-548am-3p	96.8134	NM_025142
TAOK1	hsa-miR-548aq-3p	96.8134	NM_025142
TAOK1	hsa-miR-548ah-3p	96.8134	NM_025142
TAOK1	hsa-miR-12136	96.7829	NM_025142
TAOK1	hsa-miR-552-3p	96.6684	NM_020791
TAOK1	hsa-miR-5011-5p	96.5804	NM_020791
TAOK1	hsa-miR-122b-5p	96.4207	NM_020791
TAOK1	hsa-miR-4291	96.2705	NM_020791
TAOK1	hsa-miR-548c-3p	96.2681	NM_020791
TAOK1	hsa-miR-19a-3p	96.2044	NM_025142
TAOK1	hsa-miR-4755-5p	95.844	NM_020791
TAOK1	hsa-miR-5006-3p	95.844	NM_020791
TAOK1	hsa-miR-1251-5p	95.7796	NM_020791
TAOK1	hsa-miR-548p	95.7565	NM_020791

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Motifs and transcription factors (TFs) regulating TAOK1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
TAOK1	transfac_pro__M04817	ZBTB33 (directAnnotation).
TAOK1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
TAOK1	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."