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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SUZ12

Summary for SUZ12

Gene information	Gene symbol	SUZ12
	Ensembl ID	ENSG00000178691
	Entrez ID	23512
	Gene name	SUZ12 polycomb repressive complex 2 subunit
	Synonyms	CHET9\|JJAZ1\|KIAA0160
	Gene type	protein_coding
	UniProtAcc	Q15022

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Dataset with differentially expressed gene: SUZ12

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.401352	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.318695	1.31e-10
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.507859	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.293163	2.80e-45

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Expression of SUZ12 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SUZ12

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SUZ12	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SUZ12

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SUZ12	hsa-miR-8063	98.5915	NM_001321207
SUZ12	hsa-miR-5580-3p	98.3965	NM_001321207
SUZ12	hsa-miR-607	98.2559	NM_001321207
SUZ12	hsa-miR-3671	97.5839	NM_001321207
SUZ12	hsa-miR-3913-3p	97.2799	NM_015355
SUZ12	hsa-miR-548c-3p	96.7605	NM_001321207
SUZ12	hsa-miR-3121-3p	96.3558	NM_001321207
SUZ12	hsa-miR-95-5p	96.1417	NM_001321207
SUZ12	hsa-miR-520d-5p	95.9963	NM_001321207
SUZ12	hsa-miR-524-5p	95.9963	NM_001321207
SUZ12	hsa-miR-4495	95.9162	NM_001321207
SUZ12	hsa-miR-489-3p	95.7181	NM_015355
SUZ12	hsa-miR-548d-3p	95.2231	NM_015355
SUZ12	hsa-miR-7853-5p	95.0463	NM_001321207
SUZ12	hsa-miR-105-5p	95.0463	NM_001321207
SUZ12	hsa-miR-340-5p	94.5761	NM_001321207
SUZ12	hsa-miR-590-3p	94.4288	NM_001321207
SUZ12	hsa-miR-3124-3p	94.3399	NM_015355
SUZ12	hsa-miR-4503	94.0242	NM_001321207
SUZ12	hsa-miR-548ac	94.0122	NM_015355
SUZ12	hsa-miR-548h-3p	94.0122	NM_015355
SUZ12	hsa-miR-548z	94.0122	NM_015355
SUZ12	hsa-miR-548bb-3p	94.0122	NM_015355
SUZ12	hsa-miR-6883-3p	91.729	NM_001321207
SUZ12	hsa-miR-29a-5p	91.3772	NM_015355
SUZ12	hsa-miR-6083	90.4727	NM_001321207
SUZ12	hsa-miR-548aw	90.3933	NM_001321207
SUZ12	hsa-miR-1297	90.2777	NM_001321207
SUZ12	hsa-miR-4720-3p	90.2268	NM_015355
SUZ12	hsa-miR-3938	90.0695	NM_015355
SUZ12	hsa-miR-580-5p	90.0307	NM_001321207
SUZ12	hsa-miR-7856-5p	89.9339	NM_001321207
SUZ12	hsa-miR-653-5p	89.8858	NM_015355
SUZ12	hsa-miR-6514-3p	89.7328	NM_001321207
SUZ12	hsa-miR-548aj-3p	89.528	NM_015355
SUZ12	hsa-miR-548x-3p	89.528	NM_015355
SUZ12	hsa-miR-6841-5p	88.9475	NM_001321207
SUZ12	hsa-miR-4699-3p	88.9186	NM_001321207
SUZ12	hsa-miR-26b-5p	88.8991	NM_001321207
SUZ12	hsa-miR-26a-5p	88.8991	NM_001321207
SUZ12	hsa-miR-4659b-3p	88.8246	NM_001321207
SUZ12	hsa-miR-4659a-3p	88.8246	NM_001321207
SUZ12	hsa-miR-4465	88.8135	NM_001321207
SUZ12	hsa-miR-4531	88.1615	NM_001321207
SUZ12	hsa-miR-4698	88.0796	NM_001321207
SUZ12	hsa-miR-676-5p	87.4614	NM_001321207
SUZ12	hsa-miR-642a-5p	87.3871	NM_001321207
SUZ12	hsa-miR-548aq-3p	87.147	NM_015355
SUZ12	hsa-miR-548ae-3p	87.147	NM_015355
SUZ12	hsa-miR-548ah-3p	87.147	NM_015355

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Motifs and transcription factors (TFs) regulating SUZ12

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SUZ12	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SUZ12	metacluster_172.6	CHD2; E2F1 (directAnnotation).
SUZ12	swissregulon__hs__GMEB2	GMEB2 (directAnnotation).
SUZ12	taipale_tf_pairs__E2F1_EOMES_RGGTGTNNNGGCGSNNTNNCRSNN_CAP	E2F1; EOMES (directAnnotation).
SUZ12	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
SUZ12	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
SUZ12	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
SUZ12	metacluster_182.10	ZFX (directAnnotation).
SUZ12	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).
SUZ12	transfac_public__M00024	E2F1 (directAnnotation).
SUZ12	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SUZ12	transfac_pro__M07483	CXXC1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."