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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SUMO1

Summary for SUMO1

Gene information	Gene symbol	SUMO1
	Ensembl ID	ENSG00000116030
	Entrez ID	7341
	Gene name	small ubiquitin like modifier 1
	Synonyms	GMP1\|OFC10\|PIC1\|SMT3C\|SMT3H3\|SUMO-1\|UBL1
	Gene type	protein_coding
	UniProtAcc	P63165

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Dataset with differentially expressed gene: SUMO1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.572903	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.406235	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.461149	0.00e+00
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	Malignant cells	0.318413	3.27e-18
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.469333	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.272634	1.08e-29
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.262488	1.55e-13
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.449566	5.18e-44
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.277723	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.874671	0.00e+00

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Expression of SUMO1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SUMO1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SUMO1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SUMO1	hsa-miR-4511	95.9415	NM_003352
SUMO1	hsa-miR-548c-3p	94.9521	NM_003352
SUMO1	hsa-miR-3918	93.9859	NM_003352
SUMO1	hsa-miR-6834-5p	93.6317	NM_001005782
SUMO1	hsa-miR-4272	93.1923	NM_003352
SUMO1	hsa-miR-548av-5p	92.9738	NM_001005781
SUMO1	hsa-miR-548k	92.9738	NM_001005781
SUMO1	hsa-miR-8054	92.9738	NM_001005781
SUMO1	hsa-miR-1284	92.6603	NM_001005781
SUMO1	hsa-miR-302f	91.728	NM_001005781
SUMO1	hsa-miR-501-3p	91.1442	NM_001005781
SUMO1	hsa-miR-502-3p	91.1442	NM_001005781
SUMO1	hsa-miR-570-3p	91.123	NM_003352
SUMO1	hsa-miR-7108-5p	90.7657	NM_001005781
SUMO1	hsa-miR-548n	90.7566	NM_001005782
SUMO1	hsa-miR-3133	90.6148	NM_003352
SUMO1	hsa-miR-548as-3p	90.2546	NM_003352
SUMO1	hsa-miR-665	89.8066	NM_003352
SUMO1	hsa-miR-520d-5p	89.1631	NM_003352
SUMO1	hsa-miR-524-5p	89.1631	NM_003352
SUMO1	hsa-miR-12136	89.0412	NM_001005782
SUMO1	hsa-miR-3182	88.4995	NM_003352
SUMO1	hsa-miR-496	88.2806	NM_001005781
SUMO1	hsa-miR-4664-5p	88.0969	NM_001005782
SUMO1	hsa-miR-767-5p	87.2673	NM_001005781
SUMO1	hsa-miR-133a-3p	86.3814	NM_003352
SUMO1	hsa-miR-133b	86.3814	NM_003352
SUMO1	hsa-miR-3163	84.1857	NM_003352
SUMO1	hsa-miR-495-3p	84.1348	NM_001005782
SUMO1	hsa-miR-5688	84.1348	NM_001005782
SUMO1	hsa-miR-34a-3p	83.8894	NM_001005782
SUMO1	hsa-miR-6734-5p	83.2291	NM_001005782
SUMO1	hsa-miR-342-5p	82.9894	NM_001005782
SUMO1	hsa-miR-4277	82.9107	NM_001005782
SUMO1	hsa-miR-1226-5p	82.7974	NM_001005782
SUMO1	hsa-miR-532-3p	82.7129	NM_001005782
SUMO1	hsa-miR-4653-3p	82.6695	NM_003352
SUMO1	hsa-miR-5584-5p	80.6414	NM_001005782
SUMO1	hsa-miR-4433b-3p	80.4535	NM_003352
SUMO1	hsa-miR-4786-3p	80.433	NM_001005781
SUMO1	hsa-miR-877-3p	80.3926	NM_001005781
SUMO1	hsa-miR-4433a-3p	80.1885	NM_003352

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Motifs and transcription factors (TFs) regulating SUMO1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SUMO1	metacluster_7.13	ZFX (directAnnotation).
SUMO1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SUMO1	cisbp__M00968	MTF2 (directAnnotation).
SUMO1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SUMO1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SUMO1	cisbp__M00341	PAX6 (directAnnotation).
SUMO1	metacluster_198.3	ZFP64 (directAnnotation).
SUMO1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SUMO1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SUMO1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SUMO1	cisbp__M00788	ZFY (inferredBy_Orthology).
SUMO1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SUMO1	metacluster_175.1	ZNF283 (directAnnotation).
SUMO1	hdpi__ZNF304	ZNF304 (directAnnotation).
SUMO1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SUMO1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SUMO1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SUMO1	transfac_pro__M01199	TRIM28 (directAnnotation).
SUMO1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SUMO1	metacluster_151.2	ZNF23 (directAnnotation).
SUMO1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SUMO1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SUMO1	transfac_pro__M03806	ZBTB7C (directAnnotation).
SUMO1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SUMO1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SUMO1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
SUMO1	cisbp__M00249	WT1 (directAnnotation).
SUMO1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SUMO1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SUMO1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
SUMO1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SUMO1	jaspar__MA0748.2	YY2 (directAnnotation).
SUMO1	metacluster_182.10	ZFX (directAnnotation).
SUMO1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SUMO1	hdpi__TIMELESS	TIMELESS (directAnnotation).
SUMO1	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SUMO1	hdpi__ELF2	ELF2 (directAnnotation).
SUMO1	taipale_tf_pairs__TEAD4_ETV1_RSCGGAAATRCM_CAP	ETV1; TEAD4 (directAnnotation).
SUMO1	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SUMO1	hdpi__TP73	TP73 (directAnnotation).
SUMO1	taipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_repr	ERF; FOXI1 (directAnnotation).
SUMO1	taipale_tf_pairs__GCM1_ELF1_NRCCCRNNCGGAAGNN_CAP_repr	ELF1; GCM1 (directAnnotation).
SUMO1	cisbp__M00808	MYPOP (inferredBy_Orthology).
SUMO1	transfac_pro__M04748	GABPA (directAnnotation).
SUMO1	metacluster_81.7	CREB1 (directAnnotation).
SUMO1	taipale_tf_pairs__ETV2_CEBPD_RSCGGANNTTGCGYAAN_CAP_repr	CEBPD; ETV2 (directAnnotation).
SUMO1	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
SUMO1	transfac_pro__M06249	ZNF616 (directAnnotation).
SUMO1	transfac_pro__M02089	E2F3 (directAnnotation).
SUMO1	transfac_pro__M02898	SMAD3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."