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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: STXBP3

Summary for STXBP3

Gene information	Gene symbol	STXBP3
	Ensembl ID	ENSG00000116266
	Entrez ID	6814
	Gene name	syntaxin binding protein 3
	Synonyms	UNC-18C
	Gene type	protein_coding
	UniProtAcc	O00186

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Dataset with differentially expressed gene: STXBP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.580208	2.89e-02
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.261421	1.84e-17
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.460582	2.80e-45

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Expression of STXBP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STXBP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STXBP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STXBP3	hsa-miR-4482-3p	98.6963	NM_007269
STXBP3	hsa-miR-16-5p	95.5337	NM_007269
STXBP3	hsa-miR-195-5p	94.9276	NM_007269
STXBP3	hsa-miR-15a-5p	94.6129	NM_007269
STXBP3	hsa-miR-15b-5p	94.6129	NM_007269
STXBP3	hsa-miR-6838-5p	94.6129	NM_007269
STXBP3	hsa-miR-424-5p	93.2565	NM_007269
STXBP3	hsa-miR-497-5p	93.2565	NM_007269
STXBP3	hsa-miR-6809-3p	91.1644	NM_007269
STXBP3	hsa-miR-4680-3p	89.9519	NM_007269
STXBP3	hsa-miR-3163	89.5399	NM_007269
STXBP3	hsa-miR-466	88.6404	NM_007269
STXBP3	hsa-miR-4753-3p	87.8994	NM_007269
STXBP3	hsa-miR-7974	86.7469	NM_007269
STXBP3	hsa-miR-582-5p	86.1479	NM_007269
STXBP3	hsa-miR-576-5p	85.7073	NM_007269
STXBP3	hsa-miR-154-3p	85.523	NM_007269
STXBP3	hsa-miR-487a-3p	85.523	NM_007269
STXBP3	hsa-miR-4789-3p	84.535	NM_007269
STXBP3	hsa-miR-4677-5p	83.3618	NM_007269
STXBP3	hsa-miR-1206	82.4903	NM_007269
STXBP3	hsa-miR-4279	82.2272	NM_007269
STXBP3	hsa-miR-6815-5p	81.7551	NM_007269
STXBP3	hsa-miR-6865-5p	81.7551	NM_007269

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Motifs and transcription factors (TFs) regulating STXBP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STXBP3	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
STXBP3	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."