Dataset | Source | Tissue | Cancer type level1 | Cancer type level2 | Drug type | Regimen | Timepoint | Cell type | avg_log2FC | p_val_adj |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | NK cells | 0.419306 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD4+ T cells | 0.459445 | 0.00e+00 |
GSE169246_PacBlood | patients | Peripheral blood mononuclear cells | Breast cancer | Advanced triple-negative breast cancer (TNBC) | Chemotherapy | paclitaxel | pre | CD8+ T cells | 0.27444 | 4.55e-36 |
GSE153697 | patients | Bone marrow aspirate | Acute lymphoblastic leukemia | Relapsed B-cell acute lymphoblastic leukemia (B-ALL) | Immunotherapy | anti-CD19 CAR-T | NA | Malignant cells | 0.254258 | 1.23e-06 |
GSE164237 | patients | Peripheral blood mononuclear cells | Melanoma | Advanced stages of melanoma | Immunotherapy | pembrolizumab | pre | CD8+ T cells | -0.281809 | 0.00e+00 |
Gene symbol | motif | TF_highConf |
STK38 | transfac_pro__M12694 | ZFP14 (directAnnotation). |
STK38 | metacluster_135.10 | MBD2; MBD2; MECP2; MECP2 (directAnnotation). |
STK38 | metacluster_115.1 | NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology). |
STK38 | metacluster_141.5 | NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology). |
STK38 | kznf__ZNF267_Imbeault2017_OM_RCADE | ZNF267 (directAnnotation). |
STK38 | cisbp__M00341 | PAX6 (directAnnotation). |
STK38 | kznf__ZNF90_Imbeault2017_OM_RCADE | ZNF90 (directAnnotation). |
STK38 | swissregulon__hs__CHD1 | CHD1 (directAnnotation). |
STK38 | swissregulon__hs__KLF6 | KLF6 (directAnnotation). |
STK38 | transfac_pro__M02898 | SMAD3 (directAnnotation). |
STK38 | metacluster_61.1 | DEAF1; DEAF1 (directAnnotation). |
STK38 | cisbp__M00775 | ZBTB1 (inferredBy_Orthology). |
STK38 | metacluster_144.3 | ZNF704; ZNF704 (directAnnotation). |
STK38 | transfac_pro__M09837 | ZNF449 (directAnnotation). |
STK38 | hdpi__EBF1 | EBF1 (directAnnotation). |
STK38 | kznf__ZNF730_Imbeault2017_RP_RCADE | ZNF730 (directAnnotation). |
STK38 | kznf__ZNF311_Imbeault2017_RP_ChIP-seq | ZNF311 (directAnnotation). |
STK38 | tfdimers__MD00364 | WT1 (directAnnotation). |
STK38 | hdpi__GTF3C2 | GTF3C2 (directAnnotation). |
STK38 | jaspar__MA1721.1 | ZNF93 (directAnnotation). |
STK38 | kznf__ZNF548_Imbeault2017_OM_RCADE | ZNF548 (directAnnotation). |
STK38 | metacluster_133.1 | ZNF304; ZNF304; ZSCAN22 (directAnnotation). |
STK38 | hocomoco__EGR4_HUMAN.H11MO.0.D | EGR4 (directAnnotation). |
STK38 | kznf__ZNF571_Imbeault2017_OM_RCADE | ZNF571 (directAnnotation). |
STK38 | transfac_pro__M03876 | ZBTB33 (directAnnotation). |
STK38 | transfac_pro__M04646 | FOXN4 (directAnnotation). |
STK38 | metacluster_126.2 | ZBTB4; ZBTB4 (directAnnotation). |
STK38 | kznf__ZNF383_Imbeault2017_OM_RCADE | ZNF383 (directAnnotation). |
STK38 | transfac_pro__M07329 | SP7 (directAnnotation). |
STK38 | transfac_pro__M07436 | WT1 (directAnnotation). |
STK38 | transfac_pro__M01858 | TFAP2B (directAnnotation). |
STK38 | metacluster_66.4 | ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology). |
STK38 | jaspar__MA1955.1 | FOXO1 (directAnnotation). |
STK38 | transfac_pro__M04966 | EP300 (directAnnotation). |
STK38 | jaspar__MA1954.1 | FOXO1 (directAnnotation). |
STK38 | jaspar__MA1953.1 | FOXO1 (directAnnotation). |
STK38 | jaspar__MA1956.1 | FOXO1 (directAnnotation). |
STK38 | taipale_tf_pairs__FOXO1_ETV4_RWMAACAGGAARNN_CAP | ETV4; FOXO1 (directAnnotation). |
STK38 | tfdimers__MD00204 | GABPA; NKX2-1 (directAnnotation). |
STK38 | metacluster_35.2 | EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology). |
STK38 | transfac_pro__M01783 | SP2 (directAnnotation). |
STK38 | taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr | HES7; TFAP2C (directAnnotation). |
STK38 | metacluster_135.11 | NR2C2 (directAnnotation). |
STK38 | transfac_pro__M07437 | ZBTB2 (directAnnotation). |
1 | "Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618." |
2 | "Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335." |