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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: STK17A

Summary for STK17A

Gene information	Gene symbol	STK17A
	Ensembl ID	ENSG00000164543
	Entrez ID	9263
	Gene name	serine/threonine kinase 17a
	Synonyms	DRAK1
	Gene type	protein_coding
	UniProtAcc	Q9UEE5

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Dataset with differentially expressed gene: STK17A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.0979	8.58e-06
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.292461	8.56e-43
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.487441	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.379254	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.39295	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.743742	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.679773	0.00e+00
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	NK cells	0.266201	3.93e-12
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	post	CD8+ T cells	-0.332492	8.49e-15
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.350021	5.74e-19
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.486701	8.37e-23
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.360769	1.31e-16
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.441764	1.45e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-1.09952	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.401186	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.338904	0.00e+00

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Expression of STK17A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to STK17A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating STK17A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
STK17A	hsa-miR-1290	91.2944	NM_004760
STK17A	hsa-miR-5688	91.2416	NM_004760
STK17A	hsa-miR-3122	90.9551	NM_004760
STK17A	hsa-miR-3913-5p	90.2657	NM_004760
STK17A	hsa-miR-495-3p	89.7701	NM_004760
STK17A	hsa-miR-5582-3p	89.2022	NM_004760
STK17A	hsa-miR-6873-3p	88.8928	NM_004760
STK17A	hsa-miR-96-5p	88.6076	NM_004760
STK17A	hsa-miR-12133	87.9104	NM_004760
STK17A	hsa-miR-1271-5p	87.9104	NM_004760
STK17A	hsa-miR-411-5p	87.6575	NM_004760
STK17A	hsa-miR-4709-3p	87.2167	NM_004760
STK17A	hsa-miR-1278	86.2455	NM_004760
STK17A	hsa-miR-3926	85.3714	NM_004760
STK17A	hsa-miR-653-5p	85.1785	NM_004760
STK17A	hsa-miR-5692a	85.1507	NM_004760
STK17A	hsa-miR-3677-5p	84.3322	NM_004760
STK17A	hsa-miR-3923	84.0013	NM_004760
STK17A	hsa-miR-1250-3p	83.4765	NM_004760
STK17A	hsa-miR-4712-5p	83.0985	NM_004760
STK17A	hsa-miR-770-5p	83.0985	NM_004760
STK17A	hsa-miR-3120-3p	82.6948	NM_004760
STK17A	hsa-miR-548au-3p	81.8709	NM_004760
STK17A	hsa-miR-7110-3p	81.7506	NM_004760
STK17A	hsa-miR-4420	80.1123	NM_004760
STK17A	hsa-miR-181b-3p	80.1123	NM_004760
STK17A	hsa-miR-181b-2-3p	80.1123	NM_004760

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Motifs and transcription factors (TFs) regulating STK17A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
STK17A	hdpi__ELF2	ELF2 (directAnnotation).
STK17A	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
STK17A	jaspar__MA1583.1	ZFP57 (directAnnotation).
STK17A	cisbp__M00968	MTF2 (directAnnotation).
STK17A	transfac_pro__M02898	SMAD3 (directAnnotation).
STK17A	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
STK17A	hdpi__HTATIP2	HTATIP2 (directAnnotation).
STK17A	jaspar__MA1721.1	ZNF93 (directAnnotation).
STK17A	jaspar__MA1122.1	TFDP1 (directAnnotation).
STK17A	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
STK17A	transfac_pro__M07310	SP5 (directAnnotation).
STK17A	cisbp__M00788	ZFY (inferredBy_Orthology).
STK17A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
STK17A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
STK17A	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
STK17A	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
STK17A	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
STK17A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
STK17A	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
STK17A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
STK17A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
STK17A	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
STK17A	transfac_pro__M01253	CNOT3 (directAnnotation).
STK17A	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
STK17A	metacluster_160.20	JUND; PRDM15 (directAnnotation).
STK17A	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
STK17A	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
STK17A	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
STK17A	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
STK17A	transfac_pro__M04817	ZBTB33 (directAnnotation).
STK17A	transfac_pro__M12697	ZNF142 (directAnnotation).
STK17A	metacluster_175.1	ZNF283 (directAnnotation).
STK17A	tfdimers__MD00364	WT1 (directAnnotation).
STK17A	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
STK17A	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
STK17A	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
STK17A	transfac_pro__M01973	PLAG1 (directAnnotation).
STK17A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
STK17A	tfdimers__MD00483	ZBTB14 (directAnnotation).
STK17A	metacluster_198.3	ZFP64 (directAnnotation).
STK17A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
STK17A	transfac_pro__M01303	SP1 (directAnnotation).
STK17A	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
STK17A	taipale_tf_pairs__ETV5_EOMES_RNGTGNNNNNNNNNNNNNRCRCCGGAWSN_CAP	EOMES; ETV5 (directAnnotation).
STK17A	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
STK17A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
STK17A	metacluster_144.13	HIC1; HIC1 (directAnnotation).
STK17A	transfac_pro__M00514	ATF4 (directAnnotation).
STK17A	transfac_pro__M00665	SP3 (directAnnotation).
STK17A	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
STK17A	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."