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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPEN

Summary for SPEN

Gene information	Gene symbol	SPEN
	Ensembl ID	ENSG00000065526
	Entrez ID	23013
	Gene name	spen family transcriptional repressor
	Synonyms	KIAA0929\|MINT\|RBM15C\|SHARP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SPEN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.257068	4.20e-45
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.284006	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.534735	0.00e+00

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Expression of SPEN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPEN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPEN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPEN	hsa-miR-190a-3p	99.9973	NM_015001
SPEN	hsa-miR-5011-5p	99.973	NM_015001
SPEN	hsa-miR-30a-5p	96.9142	NM_015001
SPEN	hsa-miR-30e-5p	96.9142	NM_015001
SPEN	hsa-miR-30b-5p	96.9142	NM_015001
SPEN	hsa-miR-30d-5p	96.9142	NM_015001
SPEN	hsa-miR-30c-5p	96.9142	NM_015001
SPEN	hsa-miR-12133	95.862	NM_015001
SPEN	hsa-miR-1271-5p	95.8504	NM_015001
SPEN	hsa-miR-96-5p	95.7998	NM_015001
SPEN	hsa-miR-16-1-3p	93.2368	NM_015001
SPEN	hsa-miR-656-3p	92.9413	NM_015001
SPEN	hsa-miR-6083	92.6709	NM_015001
SPEN	hsa-miR-1275	92.5463	NM_015001
SPEN	hsa-miR-1258	91.874	NM_015001
SPEN	hsa-miR-3193	91.044	NM_015001
SPEN	hsa-miR-98-3p	90.9383	NM_015001
SPEN	hsa-let-7b-3p	90.9383	NM_015001
SPEN	hsa-let-7a-3p	90.9383	NM_015001
SPEN	hsa-let-7f-1-3p	90.9383	NM_015001
SPEN	hsa-miR-495-3p	90.5443	NM_015001
SPEN	hsa-miR-5688	90.5443	NM_015001
SPEN	hsa-miR-922	90.4961	NM_015001
SPEN	hsa-miR-1260a	90.0692	NM_015001
SPEN	hsa-miR-1260b	90.0692	NM_015001
SPEN	hsa-miR-561-3p	89.4173	NM_015001
SPEN	hsa-miR-4665-5p	89.0857	NM_015001
SPEN	hsa-miR-4722-5p	89.0474	NM_015001
SPEN	hsa-miR-12130	86.7026	NM_015001
SPEN	hsa-miR-454-3p	86.6908	NM_015001
SPEN	hsa-miR-8485	86.1911	NM_015001
SPEN	hsa-miR-6780a-3p	86.0933	NM_015001
SPEN	hsa-miR-548g-3p	85.7189	NM_015001
SPEN	hsa-miR-10397-5p	85.3165	NM_015001
SPEN	hsa-miR-3189-3p	83.0184	NM_015001
SPEN	hsa-miR-515-5p	82.8086	NM_015001
SPEN	hsa-miR-519e-5p	82.8086	NM_015001
SPEN	hsa-miR-4768-3p	81.9117	NM_015001
SPEN	hsa-miR-3666	81.646	NM_015001
SPEN	hsa-miR-130a-3p	81.646	NM_015001
SPEN	hsa-miR-4295	81.646	NM_015001
SPEN	hsa-miR-301a-3p	81.646	NM_015001
SPEN	hsa-miR-301b-3p	81.646	NM_015001
SPEN	hsa-miR-130b-3p	81.646	NM_015001
SPEN	hsa-miR-629-3p	81.1627	NM_015001
SPEN	hsa-miR-4292	80.8924	NM_015001
SPEN	hsa-miR-6791-5p	80.8924	NM_015001

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Motifs and transcription factors (TFs) regulating SPEN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPEN	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SPEN	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SPEN	cisbp__M00968	MTF2 (directAnnotation).
SPEN	transfac_pro__M12697	ZNF142 (directAnnotation).
SPEN	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
SPEN	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SPEN	jaspar__MA0748.2	YY2 (directAnnotation).
SPEN	transfac_pro__M01303	SP1 (directAnnotation).
SPEN	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SPEN	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SPEN	metacluster_3.14	WT1; WT1 (directAnnotation).
SPEN	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SPEN	metacluster_24.5	ZNF675; ZNF675 (directAnnotation).
SPEN	transfac_public__M00491	PATZ1 (directAnnotation).
SPEN	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SPEN	transfac_pro__M07397	ZNF148 (directAnnotation).
SPEN	hdpi__NRL	NRL (directAnnotation).
SPEN	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SPEN	hdpi__FEZF2	FEZF2 (directAnnotation).
SPEN	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
SPEN	transfac_pro__M07310	SP5 (directAnnotation).
SPEN	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SPEN	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SPEN	metacluster_155.11	SPZ1 (directAnnotation).
SPEN	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
SPEN	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SPEN	hdpi__HTATIP2	HTATIP2 (directAnnotation).
SPEN	hdpi__HIP2	UBE2K (directAnnotation).
SPEN	hdpi__ZNF304	ZNF304 (directAnnotation).
SPEN	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
SPEN	hocomoco__ZBT14_HUMAN.H11MO.0.C	ZBTB14 (directAnnotation).
SPEN	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
SPEN	transfac_pro__M02089	E2F3 (directAnnotation).
SPEN	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."