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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPATS2L

Summary for SPATS2L

Gene information	Gene symbol	SPATS2L
	Ensembl ID	ENSG00000196141
	Entrez ID	26010
	Gene name	spermatogenesis associated serine rich 2 like
	Synonyms	DNAPTP6\|SGNP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SPATS2L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	-0.272176	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-1.64391	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.299185	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.337572	1.63e-22
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.599166	2.37e-43
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.432841	3.53e-36
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.455668	6.42e-26
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.354196	0.00e+00
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	-0.303366	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.429657	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.438783	0.00e+00

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Expression of SPATS2L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPATS2L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPATS2L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPATS2L	hsa-miR-5011-5p	99.6916	NM_001100422
SPATS2L	hsa-miR-616-5p	98.7806	NM_001100423
SPATS2L	hsa-miR-371b-5p	98.7806	NM_001100423
SPATS2L	hsa-miR-373-5p	98.7806	NM_001100423
SPATS2L	hsa-miR-607	98.4844	NM_001100422
SPATS2L	hsa-miR-190a-3p	98.1017	NM_001100422
SPATS2L	hsa-miR-103a-3p	94.202	NM_001100423
SPATS2L	hsa-miR-107	94.202	NM_001100423
SPATS2L	hsa-miR-3613-3p	93.6761	NM_001100422
SPATS2L	hsa-miR-885-3p	91.2993	NM_001100422
SPATS2L	hsa-miR-520f-5p	90.6042	NM_001100422
SPATS2L	hsa-miR-1288-5p	89.8299	NM_001100422
SPATS2L	hsa-miR-3671	89.7131	NM_001100423
SPATS2L	hsa-miR-3148	87.3693	NM_001100423
SPATS2L	hsa-miR-4668-3p	87.2231	NM_001100423
SPATS2L	hsa-miR-6501-3p	87.1503	NM_001100423
SPATS2L	hsa-miR-1283	85.0854	NM_001100422
SPATS2L	hsa-miR-3685	84.5272	NM_001100422
SPATS2L	hsa-miR-10527-5p	84.1376	NM_001100422
SPATS2L	hsa-miR-3065-3p	83.9802	NM_001100422
SPATS2L	hsa-miR-3920	83.7979	NM_001100423
SPATS2L	hsa-miR-95-5p	82.0215	NM_001100423
SPATS2L	hsa-miR-6734-3p	81.7503	NM_001100422
SPATS2L	hsa-miR-6849-3p	81.7069	NM_001100423
SPATS2L	hsa-miR-384	81.3996	NM_001100422
SPATS2L	hsa-miR-922	81.3846	NM_001100423
SPATS2L	hsa-miR-548c-3p	80.9886	NM_001100423
SPATS2L	hsa-miR-7853-5p	80.4982	NM_001100422
SPATS2L	hsa-miR-105-5p	80.4982	NM_001100422
SPATS2L	hsa-miR-24-3p	80.4062	NM_001100423
SPATS2L	hsa-miR-500a-5p	80.1447	NM_001100423

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Motifs and transcription factors (TFs) regulating SPATS2L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPATS2L	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
SPATS2L	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
SPATS2L	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
SPATS2L	jaspar__MA1509.1	IRF6 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."