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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SPAG9

Summary for SPAG9

Gene information	Gene symbol	SPAG9
	Ensembl ID	ENSG00000008294
	Entrez ID	9043
	Gene name	sperm associated antigen 9
	Synonyms	CT89\|FLJ13450\|FLJ14006\|FLJ26141\|FLJ34602\|HLC4\|HSS\|JIP-4\|JIP4\|JLP\|KIAA0516\|MGC117291\|MGC14967\|MGC74461\|PHET\|PIG6\|SYD1
	Gene type	protein_coding
	UniProtAcc	O60271

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Dataset with differentially expressed gene: SPAG9

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.250848	8.51e-11
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.314258	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.367959	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.857023	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.298757	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.33162	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.292371	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.407556	4.81e-19

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Expression of SPAG9 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SPAG9

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SPAG9

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SPAG9	hsa-miR-373-5p	99.5032	NM_001130527
SPAG9	hsa-miR-616-5p	99.5032	NM_001130527
SPAG9	hsa-miR-371b-5p	99.5032	NM_001130527
SPAG9	hsa-miR-3613-3p	98.509	NM_001130527
SPAG9	hsa-miR-548at-5p	98.4271	NM_001130527
SPAG9	hsa-miR-5680	98.2861	NM_001130527
SPAG9	hsa-miR-6732-3p	98.169	NM_001130527
SPAG9	hsa-miR-548ah-5p	97.1634	NM_001130527
SPAG9	hsa-miR-3609	97.1634	NM_001130527
SPAG9	hsa-miR-6875-3p	96.9842	NM_001130527
SPAG9	hsa-miR-4502	96.9733	NM_001130527
SPAG9	hsa-miR-6866-5p	96.3856	NM_001130527
SPAG9	hsa-miR-190a-3p	95.7029	NM_001130527
SPAG9	hsa-miR-3160-5p	95.2886	NM_001130527
SPAG9	hsa-miR-4696	94.8636	NM_001130527
SPAG9	hsa-miR-627-3p	94.8235	NM_001130527
SPAG9	hsa-miR-6757-3p	94.6401	NM_001130527
SPAG9	hsa-miR-1178-3p	94.0672	NM_001130527
SPAG9	hsa-miR-375-3p	93.9953	NM_001130527
SPAG9	hsa-miR-3148	93.9177	NM_001130527
SPAG9	hsa-miR-218-5p	93.8192	NM_001130527
SPAG9	hsa-miR-582-5p	93.4862	NM_001130527
SPAG9	hsa-miR-1206	92.8726	NM_001130527
SPAG9	hsa-miR-6853-3p	92.8726	NM_001130527
SPAG9	hsa-miR-200a-3p	92.2627	NM_001130527
SPAG9	hsa-miR-5011-5p	92.1018	NM_001130527
SPAG9	hsa-miR-6739-3p	92.0202	NM_001130527
SPAG9	hsa-miR-4524a-3p	91.9959	NM_001130527
SPAG9	hsa-miR-1276	91.8989	NM_001130527
SPAG9	hsa-miR-587	91.6654	NM_001130527
SPAG9	hsa-miR-570-3p	91.5464	NM_001130527
SPAG9	hsa-miR-200c-3p	91.4448	NM_001130527
SPAG9	hsa-miR-200b-3p	91.4448	NM_001130527
SPAG9	hsa-miR-429	91.4448	NM_001130527
SPAG9	hsa-miR-298	91.1385	NM_001130527
SPAG9	hsa-miR-4729	90.8124	NM_001130527
SPAG9	hsa-miR-6074	90.7098	NM_001130527
SPAG9	hsa-miR-340-5p	90.5104	NM_001130527
SPAG9	hsa-miR-6873-5p	90.3425	NM_001130527
SPAG9	hsa-miR-24-3p	90.095	NM_001130527
SPAG9	hsa-miR-3120-3p	89.9328	NM_001130527
SPAG9	hsa-miR-577	89.8849	NM_001130527
SPAG9	hsa-miR-141-3p	89.7567	NM_001130527
SPAG9	hsa-miR-561-3p	89.4236	NM_001130527
SPAG9	hsa-miR-3658	89.3989	NM_001130527
SPAG9	hsa-miR-892c-5p	89.0777	NM_001130527
SPAG9	hsa-miR-652-5p	89.0558	NM_001130527
SPAG9	hsa-miR-1285-5p	88.6722	NM_001130527
SPAG9	hsa-miR-4282	88.6137	NM_001130527
SPAG9	hsa-miR-372-5p	87.7664	NM_001130527

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Motifs and transcription factors (TFs) regulating SPAG9

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SPAG9	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
SPAG9	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SPAG9	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
SPAG9	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SPAG9	hdpi__HIP2	UBE2K (directAnnotation).
SPAG9	transfac_pro__M02913	SP140 (inferredBy_Orthology).
SPAG9	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SPAG9	transfac_pro__M02898	SMAD3 (directAnnotation).
SPAG9	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SPAG9	hdpi__TIMELESS	TIMELESS (directAnnotation).
SPAG9	transfac_pro__M04893	TAF1 (directAnnotation).
SPAG9	transfac_pro__M00430	E2F1 (directAnnotation).
SPAG9	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SPAG9	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SPAG9	transfac_pro__M00938	E2F1 (directAnnotation).
SPAG9	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SPAG9	jaspar__MA1721.1	ZNF93 (directAnnotation).
SPAG9	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SPAG9	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SPAG9	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
SPAG9	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SPAG9	transfac_pro__M01253	CNOT3 (directAnnotation).
SPAG9	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SPAG9	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SPAG9	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SPAG9	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
SPAG9	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
SPAG9	transfac_pro__M07310	SP5 (directAnnotation).
SPAG9	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SPAG9	transfac_pro__M04817	ZBTB33 (directAnnotation).
SPAG9	transfac_pro__M12697	ZNF142 (directAnnotation).
SPAG9	tfdimers__MD00364	WT1 (directAnnotation).
SPAG9	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SPAG9	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
SPAG9	transfac_pro__M01973	PLAG1 (directAnnotation).
SPAG9	tfdimers__MD00483	ZBTB14 (directAnnotation).
SPAG9	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
SPAG9	metacluster_143.13	ZBTB7A (directAnnotation).
SPAG9	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
SPAG9	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
SPAG9	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
SPAG9	metacluster_144.13	HIC1; HIC1 (directAnnotation).
SPAG9	transfac_pro__M00514	ATF4 (directAnnotation).
SPAG9	transfac_pro__M00665	SP3 (directAnnotation).
SPAG9	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SPAG9	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
SPAG9	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).
SPAG9	metacluster_196.3	NR1H4; NR2F6; PRDM14; ZNF264; ZNF264 (directAnnotation). HNF4A; HNF4G; NR1D1; NR1D1; NR1D1; NR1D2; NR1D2; NR1D2; NR1H2; NR1H2; NR1H2; NR1H3; NR1H3; NR1H3; NR1I2; NR1I2; NR1I2; NR2C1; NR2C2; NR2F2; NR2F6; PPARA; PPARA; PPARA; PPARD; PPARD; PPARD; PPARG; PPARG; PPARG; RARA; RARA; RARA; RARB; RARB; RARB; RORA; RORA; RORA; RORB; RORB; RORB; RORC; RORC; RORC; RXRA; RXRB; RXRG; THRA; THRA; THRA; VDR; VDR; VDR (inferredBy_Orthology).
SPAG9	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
SPAG9	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."