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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SON

Summary for SON

Gene information	Gene symbol	SON
	Ensembl ID	ENSG00000159140
	Entrez ID	6651
	Gene name	SON DNA and RNA binding protein
	Synonyms	BASS1\|C21orf50\|DBP-5\|FLJ21099\|FLJ33914\|KIAA1019\|NREBP
	Gene type	protein_coding
	UniProtAcc	P18583

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Dataset with differentially expressed gene: SON

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.472524	0.00e+00
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.542542	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD8+ T cells	-0.339955	2.42e-20
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	NK cells	-0.382257	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	cDCs	-0.576092	1.36e-09
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.634062	5.46e-16
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	CD4+ T cells	-0.344128	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.337041	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.279193	5.62e-24
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.366614	2.38e-12
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.433983	5.70e-27
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	-0.373519	1.58e-16
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	0.431556	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	0.286312	6.40e-21
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	CD8+ T cells	0.340429	3.14e-05
GSE162117	patients	Peripheral blood mononuclear cells	Acute myeloid leukemia	Tefractory acute myeloid leukemia (AML)	Targeted therapy	ficlatuzumab	pre	CD4+ T cells	0.343895	1.10e-27
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.526075	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.605967	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.527932	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.513043	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.473171	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-1.1581	8.09e-08
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.792402	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.530744	0.00e+00

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Expression of SON in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SON

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SON

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SON	hsa-miR-5011-5p	99.8916	NM_032195
SON	hsa-miR-190a-3p	99.2419	NM_032195
SON	hsa-miR-302e	95.3969	NM_001291411
SON	hsa-miR-302d-3p	95.3969	NM_001291411
SON	hsa-miR-302c-3p	95.3969	NM_001291411
SON	hsa-miR-302b-3p	95.3969	NM_001291411
SON	hsa-miR-302a-3p	95.3969	NM_001291411
SON	hsa-miR-5196-5p	94.9864	NM_032195
SON	hsa-miR-4747-5p	94.9864	NM_032195
SON	hsa-miR-3065-5p	94.7132	NM_001291412
SON	hsa-miR-520e-3p	94.4961	NM_001291411
SON	hsa-miR-520c-3p	94.4961	NM_001291411
SON	hsa-miR-372-3p	94.4961	NM_001291411
SON	hsa-miR-520d-3p	94.4961	NM_001291411
SON	hsa-miR-520a-3p	94.4961	NM_001291411
SON	hsa-miR-520b-3p	94.4961	NM_001291411
SON	hsa-miR-373-3p	94.4961	NM_001291411
SON	hsa-miR-3613-3p	94.3338	NM_001291411
SON	hsa-miR-6895-3p	93.1797	NM_001291411
SON	hsa-miR-499b-3p	93.0438	NM_001291412
SON	hsa-miR-499a-3p	93.0438	NM_001291412
SON	hsa-miR-4692	92.9432	NM_001291411
SON	hsa-miR-4428	92.8517	NM_001291411
SON	hsa-miR-144-3p	92.8143	NM_001291412
SON	hsa-miR-3133	92.7172	NM_001291411
SON	hsa-miR-548ai	92.0838	NM_001291412
SON	hsa-miR-570-5p	92.0838	NM_001291412
SON	hsa-miR-548ba	92.0838	NM_001291412
SON	hsa-miR-548ag	92.0838	NM_001291412
SON	hsa-miR-1286	92.032	NM_001291412
SON	hsa-miR-7151-3p	91.6848	NM_001291412
SON	hsa-miR-3140-3p	91.5187	NM_001291412
SON	hsa-miR-4760-3p	91.4642	NM_001291411
SON	hsa-miR-548g-3p	91.2983	NM_032195
SON	hsa-miR-520a-5p	91.1264	NM_001291412
SON	hsa-miR-525-5p	91.1264	NM_001291412
SON	hsa-miR-505-3p	91.0842	NM_001291412
SON	hsa-miR-4643	91.0576	NM_001291412
SON	hsa-miR-4514	90.8963	NM_001291411
SON	hsa-miR-1283	90.8845	NM_001291412
SON	hsa-miR-6734-5p	90.2833	NM_001291412
SON	hsa-miR-103a-2-5p	90.0535	NM_001291412
SON	hsa-miR-103a-1-5p	90.0535	NM_001291412
SON	hsa-miR-561-3p	89.4187	NM_001291412
SON	hsa-miR-4492	89.2446	NM_001291412
SON	hsa-miR-1912-3p	88.9105	NM_001291412
SON	hsa-miR-1295b-5p	88.9105	NM_001291412
SON	hsa-miR-4477a	88.6748	NM_032195
SON	hsa-miR-4700-5p	87.7359	NM_001291411
SON	hsa-miR-6838-5p	87.6424	NM_001291411

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Motifs and transcription factors (TFs) regulating SON

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SON	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
SON	hdpi__TP73	TP73 (directAnnotation).
SON	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
SON	transfac_public__M00024	E2F1 (directAnnotation).
SON	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SON	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
SON	tfdimers__MD00364	WT1 (directAnnotation).
SON	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SON	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
SON	transfac_pro__M01973	PLAG1 (directAnnotation).
SON	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
SON	metacluster_143.13	ZBTB7A (directAnnotation).
SON	tfdimers__MD00552	USF2; ZBTB14 (directAnnotation).
SON	transfac_pro__M07387	ZBTB7A (directAnnotation).
SON	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SON	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
SON	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
SON	hocomoco__ZFX_MOUSE.H11MO.1.B	ZFY (inferredBy_Orthology).
SON	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
SON	jaspar__MA1154.1	ZNF282 (directAnnotation).
SON	transfac_pro__M01150	DMRTA2 (directAnnotation).
SON	transfac_pro__M02109	NKX2-2 (directAnnotation).
SON	transfac_pro__M06784	ZNF780B (directAnnotation).
SON	metacluster_44.13	NKX3-1; NKX3-2 (directAnnotation).
SON	metacluster_197.1	E2F2; E2F3; E2F3; E2F4 (directAnnotation).
SON	kznf__ZNF302_Imbeault2017_OM_RCADE	ZNF302 (directAnnotation).
SON	transfac_pro__M06786	ZNF646 (directAnnotation).
SON	transfac_pro__M05997	ZFP64 (directAnnotation).
SON	metacluster_44.4	NKX3-1 (inferredBy_Orthology).
SON	metacluster_44.5	NKX3-1 (inferredBy_Orthology).
SON	metacluster_71.5	HIF1A (directAnnotation).
SON	taipale_tf_pairs__ETV2_RFX5_NACTTCCGGYNNNNGCAACSN_CAP_repr	ETV2; RFX5 (directAnnotation).
SON	metacluster_44.6	NKX2-5 (directAnnotation).
SON	taipale_tf_pairs__TEAD4_CLOCK_NCACGTGNNNNNNCATWCC_CAP_repr	CLOCK; TEAD4 (directAnnotation).
SON	tfdimers__MD00336	IRF8; STAT1 (directAnnotation).
SON	tfdimers__MD00056	EP300; ZEB1 (directAnnotation).
SON	c2h2_zfs__M0401	ZNF410 (inferredBy_Orthology).
SON	metacluster_172.8	SIX1 (directAnnotation).
SON	metacluster_161.16	NKX3-2 (directAnnotation).
SON	metacluster_161.4	LHX9 (directAnnotation).
SON	homer__GGCVGTTR_MYB	MYB (inferredBy_Orthology).
SON	metacluster_76.1	ZNF345; ZNF345 (directAnnotation). MYB; MYBL1 (inferredBy_Orthology).
SON	metacluster_160.2	FEZF1; FEZF2 (directAnnotation).
SON	transfac_public__M00415	ZEB1 (directAnnotation).
SON	jaspar__MA1489.1	FOXN3 (directAnnotation).
SON	transfac_pro__M05329	KLF16 (inferredBy_Orthology).
SON	taipale_tf_pairs__TEAD4_ERG_RSCGGAAATRCC_CAP_repr	ERG; TEAD4 (directAnnotation).
SON	flyfactorsurvey__Sug_F3-5-2_SOLEXA_5	GLIS2 (inferredBy_Orthology).
SON	swissregulon__hs__MYB	MYB (directAnnotation).
SON	metacluster_7.11	PRDM4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."