Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SNX18

Summary for SNX18

Gene information	Gene symbol	SNX18
	Ensembl ID	ENSG00000178996
	Entrez ID	112574
	Gene name	sorting nexin 18
	Synonyms	SH3PX2\|SH3PXD3B\|SNAG1
	Gene type	protein_coding
	UniProtAcc	Q96RF0

Top

Dataset with differentially expressed gene: SNX18

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.32568	2.12e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.566537	2.82e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.491442	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.419687	2.82e-39

Top

Expression of SNX18 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SNX18

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SNX18

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNX18	hsa-miR-506-3p	99.2402	NM_001145427
SNX18	hsa-miR-124-3p	99.2402	NM_001145427
SNX18	hsa-miR-3143	99.1383	NM_001145427
SNX18	hsa-miR-3910	97.8366	NM_001145427
SNX18	hsa-miR-4676-3p	97.6889	NM_001102575
SNX18	hsa-miR-892c-3p	97.6889	NM_001102575
SNX18	hsa-miR-452-5p	97.6658	NM_001102575
SNX18	hsa-miR-6809-3p	97.6404	NM_001145427
SNX18	hsa-miR-30e-5p	97.6333	NM_001145427
SNX18	hsa-miR-30a-5p	97.6333	NM_001145427
SNX18	hsa-miR-30c-5p	97.6333	NM_001145427
SNX18	hsa-miR-30d-5p	97.6333	NM_001145427
SNX18	hsa-miR-30b-5p	97.6333	NM_001145427
SNX18	hsa-miR-629-5p	96.7411	NM_001102575
SNX18	hsa-miR-3685	95.0603	NM_001102575
SNX18	hsa-miR-548an	95.0525	NM_001145427
SNX18	hsa-miR-3714	94.0128	NM_001145427
SNX18	hsa-miR-543	93.9013	NM_001145427
SNX18	hsa-miR-4482-3p	93.3122	NM_001145427
SNX18	hsa-miR-548e-5p	93.203	NM_001102575
SNX18	hsa-miR-1252-5p	92.8736	NM_001102575
SNX18	hsa-miR-32-3p	92.6696	NM_001102575
SNX18	hsa-miR-627-3p	92.3322	NM_001145427
SNX18	hsa-miR-1283	92.2011	NM_001102575
SNX18	hsa-miR-670-5p	92.1926	NM_001145427
SNX18	hsa-miR-875-5p	92.1726	NM_001145427
SNX18	hsa-miR-10397-5p	92.1118	NM_001145427
SNX18	hsa-miR-4253	92.07	NM_001145427
SNX18	hsa-miR-6862-5p	92.07	NM_001145427
SNX18	hsa-miR-374b-5p	91.8498	NM_001102575
SNX18	hsa-miR-5006-3p	91.4901	NM_001145427
SNX18	hsa-miR-4755-5p	91.4901	NM_001145427
SNX18	hsa-miR-3119	91.1385	NM_001145427
SNX18	hsa-miR-345-3p	91.1263	NM_001145427
SNX18	hsa-miR-374a-5p	91.029	NM_001102575
SNX18	hsa-miR-3919	90.8034	NM_001145427
SNX18	hsa-miR-5680	90.6515	NM_001145427
SNX18	hsa-miR-7856-5p	90.4716	NM_001102575
SNX18	hsa-miR-155-3p	90.16	NM_001102575
SNX18	hsa-miR-3140-3p	90.0093	NM_001145427
SNX18	hsa-miR-6839-3p	89.7738	NM_001102575
SNX18	hsa-miR-203b-3p	89.4986	NM_001102575
SNX18	hsa-miR-548z	89.4267	NM_001145427
SNX18	hsa-miR-548bb-3p	89.4267	NM_001145427
SNX18	hsa-miR-548h-3p	89.4267	NM_001145427
SNX18	hsa-miR-548ac	89.4267	NM_001145427
SNX18	hsa-miR-548d-3p	89.4267	NM_001145427
SNX18	hsa-miR-218-5p	88.9098	NM_001145427
SNX18	hsa-miR-4667-3p	88.0954	NM_001102575
SNX18	hsa-miR-149-5p	88.0618	NM_001145427

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating SNX18

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNX18	hocomoco__XBP1_HUMAN.H11MO.0.D	XBP1 (directAnnotation).
SNX18	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SNX18	metacluster_144.13	HIC1; HIC1 (directAnnotation).
SNX18	kznf__ZNF548_Imbeault2017_OM_RCADE	ZNF548 (directAnnotation).
SNX18	hocomoco__ZFP57_MOUSE.H11MO.0.B	ZFP57 (inferredBy_Orthology).
SNX18	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
SNX18	tfdimers__MD00274	MYCN (directAnnotation).
SNX18	transfac_pro__M03847	SOX15 (directAnnotation).
SNX18	transfac_pro__M05664	ZNF853 (directAnnotation).
SNX18	transfac_pro__M05933	ZNF552 (directAnnotation).
SNX18	tfdimers__MD00140	IRF1; OTX1; OTX2 (directAnnotation).
SNX18	transfac_pro__M05722	ZNF8 (directAnnotation).
SNX18	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
SNX18	transfac_pro__M05852	ZNF689 (directAnnotation).
SNX18	transfac_pro__M06049	ZNF208 (directAnnotation).
SNX18	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
SNX18	tfdimers__MD00064	E2F1; LTF (directAnnotation).
SNX18	transfac_pro__M05462	ZNF581 (directAnnotation).
SNX18	taipale_tf_pairs__TEAD4_PITX1_RCATTCNNNNNTAATCC_CAP	PITX1; TEAD4 (directAnnotation).
SNX18	transfac_pro__M04906	SIN3A (directAnnotation).
SNX18	taipale_tf_pairs__TEAD4_PITX1_RCATWCYNNNNTAATCC_CAP_repr	PITX1; TEAD4 (directAnnotation).
SNX18	transfac_pro__M06425	ZNF227 (directAnnotation).
SNX18	taipale_tf_pairs__POU2F1_ELK1_NCCGGATATGCAN_CAP_repr	ELK1; POU2F1 (directAnnotation).
SNX18	transfac_pro__M06702	ZNF226 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."