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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SNCA

Summary for SNCA

Gene information	Gene symbol	SNCA
	Ensembl ID	ENSG00000145335
	Entrez ID	6622
	Gene name	synuclein alpha
	Synonyms	NACP\|PARK1\|PARK4\|PD1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SNCA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE197268_Axi-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	axi-cel (CAR-T)	pre	NK cells	-0.686771	0.00e+00
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Erythrocytes	0.462493	2.61e-26
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	0.69382	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.708152	3.45e-32
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	-0.26877	2.01e-13
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.280149	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.470107	0.00e+00

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Expression of SNCA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SNCA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNCA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNCA	hsa-miR-190a-3p	99.6886	NM_000345
SNCA	hsa-miR-5011-5p	98.91	NM_000345
SNCA	hsa-miR-6515-3p	94.4177	NM_001146055
SNCA	hsa-miR-106a-3p	94.1053	NM_000345
SNCA	hsa-miR-1178-3p	92.534	NM_000345
SNCA	hsa-miR-7-5p	92.4558	NM_000345
SNCA	hsa-miR-4786-3p	91.6898	NM_000345
SNCA	hsa-miR-450b-5p	91.4416	NM_001146055
SNCA	hsa-miR-7843-3p	90.6001	NM_000345
SNCA	hsa-miR-4795-3p	89.7112	NM_001146055
SNCA	hsa-miR-1229-3p	88.7037	NM_001146055
SNCA	hsa-miR-548c-3p	87.5427	NM_001146055
SNCA	hsa-miR-6509-5p	85.5753	NM_001146055
SNCA	hsa-miR-6511a-3p	85.412	NM_001146055
SNCA	hsa-miR-6511b-3p	85.412	NM_001146055
SNCA	hsa-miR-7-1-3p	84.8452	NM_001146055
SNCA	hsa-miR-7-2-3p	84.8452	NM_001146055
SNCA	hsa-miR-513c-3p	83.5155	NM_001146055
SNCA	hsa-miR-513a-3p	83.5155	NM_001146055
SNCA	hsa-miR-4277	83.4424	NM_000345
SNCA	hsa-miR-6873-3p	83.3596	NM_001146055
SNCA	hsa-miR-335-3p	83.3456	NM_001146055
SNCA	hsa-miR-6890-3p	82.6527	NM_001146055
SNCA	hsa-miR-3606-3p	82.5956	NM_001146055
SNCA	hsa-miR-8075	81.6548	NM_000345
SNCA	hsa-miR-5680	80.6167	NM_001146055

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Motifs and transcription factors (TFs) regulating SNCA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNCA	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP	ELK1; TBX21 (directAnnotation).
SNCA	metacluster_160.3	ZFP14; ZNF419 (directAnnotation).
SNCA	taipale_tf_pairs__E2F3_DRGX_SGCGCTAATTKN_CAP_repr	DRGX; E2F3 (directAnnotation).
SNCA	transfac_pro__M06382	ZNF773 (directAnnotation).
SNCA	kznf__GTF3A_Schmitges2016_RCADE	GTF3A (directAnnotation).
SNCA	transfac_pro__M06099	ZNF14 (directAnnotation).
SNCA	transfac_pro__M06592	ZNF486 (directAnnotation).
SNCA	transfac_pro__M01973	PLAG1 (directAnnotation).
SNCA	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
SNCA	metacluster_143.13	ZBTB7A (directAnnotation).
SNCA	taipale_tf_pairs__TEAD4_CEBPD_RGWATGYNNTTRCGYAAN_CAP	CEBPD; TEAD4 (directAnnotation).
SNCA	hdpi__TIMELESS	TIMELESS (directAnnotation).
SNCA	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
SNCA	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SNCA	metacluster_44.37	HMX2 (directAnnotation).
SNCA	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_repr	ZNF385D (directAnnotation).
SNCA	jaspar__MA1122.1	TFDP1 (directAnnotation).
SNCA	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
SNCA	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
SNCA	transfac_pro__M01175	ZBTB7B (directAnnotation).
SNCA	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
SNCA	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SNCA	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SNCA	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SNCA	jaspar__MA1483.2	ELF2 (directAnnotation).
SNCA	transfac_pro__M04826	EP300 (directAnnotation).
SNCA	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
SNCA	hdpi__TP73	TP73 (directAnnotation).
SNCA	jaspar__MA1933.1	SREBF2 (directAnnotation).
SNCA	swissregulon__mm__E2f7	E2F7 (inferredBy_Orthology).
SNCA	jaspar__MA1708.1	ETV7 (directAnnotation).
SNCA	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
SNCA	swissregulon__hs__ELK1	ELK1 (directAnnotation).
SNCA	metacluster_183.4	ETS1 (inferredBy_Orthology).
SNCA	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SNCA	"Copper"	DB09130	small molecule
SNCA	"Dequalinium"	DB04209	small molecule
SNCA	"Resveratrol"	DB02709	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."